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52 Possible Causes for Extremity Ataxia, Macrocytosis, Progressive Polyneuropathy

  • Vitamin B12 Deficiency

    peripheral neuropathy, and spinal degeneration.[ncbi.nlm.nih.gov] In later stages, spasticity, extensor plantar responses, greater loss of position and vibratory sensation in the lower extremities, and ataxia emerge.[merckmanuals.com] We report a case of a 46-year-old Moroccan man presenting with severe hemolytic anemia, thrombocytopenia, and renal failure in absence of macrocytosis, thus mimicking a genuine[ncbi.nlm.nih.gov]

  • Chronic Alcoholism

    Wernicke-Korsakoff syndrome (ataxia, confusion, ophthalmoplegia), amnesic problems, peripheral neuropathy and dementia.[patient.info] Alcohol is a common cause of macrocytosis, with a mean corpuscular volume (MCV) of 100-110 fL seen in a majority of patients.[symptoma.com] Alcoholism can also cause mild macrocytosis independent of folate deficiency, due to a direct effect on the bone marrow (common: 90% of alcoholics have MCV of 100-110 even[errolozdalga.com]

  • Pernicious Anemia

    We describe a case of a young black woman with gradually progressive lower extremity paresthesias, weakness, and ataxia as the primary presenting symptoms of pernicious anemia[ncbi.nlm.nih.gov] BACKGROUND/PURPOSE: Macrocytosis is defined as having the mean corpuscular volume (MCV) 100 fL.[ncbi.nlm.nih.gov] ), ataxia and positive Babinski reflexes.[doi.org]

  • Subacute Combined Degeneration of Spinal Cord

    Case Presentation: A 28‐year‐old nursing student with a history of bipolar disorder presented to Tucson Medical Center with symptoms of ataxia and bilateral lower‐extremity[shmabstracts.com] Moreover, no haematological alterations like macrocytosis were determined.[bmcresnotes.biomedcentral.com] He presented acutely with tremors, diaphoresis, insomnia, ataxia (progressive over the last three months), lower extremity paresthesias, decreased somatosensory perception[em-consulte.com]

  • Vasculitis

    Neuropathy Sensory or Sensory-Motor General patterns Mononeuritis multiplex (13%) Asymmetric polyneuropathy (85%) Distal symmetric polyneuropathy (2%) More slowly progressive[neuromuscular.wustl.edu] […] laboratory tests and have been associated with spurious quantitation of plasma proteins and erythrocyte sedimentation rate, pseudo-leucocytosis, pseudo-thrombocytosis or pseudo-macrocytosis[journals.lww.com] Sensory loss: Large Small fiber modalities Gait: Sensory ataxia; Romberg positive Motor: Normal strength Tendon reflexes: Absent or Reduced Course Neuropathy onset: 1 to[neuromuscular.wustl.edu]

  • Vitamin Deficiency

    ., numbness) of the extremities and gait ataxia. 1 Neuropsychiatric symptoms may occur secondary to vitamin B 12 deficiency, such as delirium manifesting as slowed thinking[uspharmacist.com] […] sensorimotor polyneuropathy.[ncbi.nlm.nih.gov] This results in megaloblastic change, which causes production of larger-than-normal erythrocytes (macrocytosis).[nap.edu]

  • Transcobalamin 2 Deficiency

    peripheral neuropathy with pronounced anemia, Spinal degeneration, Brain atrophy, and macrocytic cells.[vitaminb12deficiency.net.au] In later stages, spasticity, extensor plantar responses, greater loss of position and vibratory sensation in the lower extremities, and ataxia emerge.[merckmanuals.com] Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med. 1988;318:1720–8.[bmcresnotes.biomedcentral.com]

  • Hereditary Orotic Aciduria

    Clinical features Ataxia, chorea, and axonal polyneuropathy Cutaneous photosensitivity and multiple cancers Mental and motor retardation Microcephaly Sensorineural deafness[emedicine.medscape.com] In most surveys, the most common cause of macrocytosis is megaloblastic anemia.[enotes.tripod.com] It is characterized by extremely low plasma levels of Apo-B, as well as low levels of total cholesterol and LDL cholesterol. Table 5.[emedicine.medscape.com]

  • Whipple Disease

    A 58-year-old man with dizziness and unsteady gait had a 10-year history of behavioral change, impotence, and a progressive peripheral neuropathy.[ncbi.nlm.nih.gov] Results Subject 1 A 54-year-old man presented with hypersomnia, weight gain, lower extremity weakness, dysarthria, confusion, and gait ataxia.[ajnr.org]

  • Glutamate Formiminotransferase Deficiency

    […] characterized by severe motor retardation and progressive scoliosis.[amp.pharm.mssm.edu] […] and spasticity Paroxysmal exertion-induced dyskinesia Paroxysmal extreme pain disorder Paroxysmal kinesigenic choreathetosis Paroxysmal kinesigenic dyskinesia Paroxysmal[csbg.cnb.csic.es] […] predominant 2, autosomal dominant Postaxial polydactyly type A6 Pyloric stenosis, infantile hypertrophic, 5 Cerebellar ataxia, deafness, and narcolepsy Congenital disorder[amp.pharm.mssm.edu]

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