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17 Possible Causes for Extremity Ataxia, Mean Corpuscular Volume Increased, Progressive Polyneuropathy

  • Vitamin B12 Deficiency

    peripheral neuropathy, and spinal degeneration.[ncbi.nlm.nih.gov] In later stages, spasticity, extensor plantar responses, greater loss of position and vibratory sensation in the lower extremities, and ataxia emerge.[merckmanuals.com] Hematological presentation of cobalamin deficiency ranges from the incidental increase of mean corpuscular volume and neutrophil hypersegmentation to symptoms due to severe[ncbi.nlm.nih.gov]

  • Chronic Alcoholism

    Wernicke-Korsakoff syndrome (ataxia, confusion, ophthalmoplegia), amnesic problems, peripheral neuropathy and dementia.[patient.info] Serum electrolytes, mean corpuscular volume (MCV) and serum uric acid levels are also indicative of ALD in combination with results from other tests.[hopkinsmedicine.org] Investigations Alcohol level is useful in acute comatose state: Alcohol level 300 mg/100 ml extreme intoxication (drowsiness and then coma).[patient.info]

  • Pernicious Anemia

    We describe a case of a young black woman with gradually progressive lower extremity paresthesias, weakness, and ataxia as the primary presenting symptoms of pernicious anemia[ncbi.nlm.nih.gov] Diagnostic methods Diagnosis depends on blood tests that show low serum levels of cobalamin and megaloblastic anemia (decreased red blood cell count and increased mean corpuscular[orpha.net] ), ataxia and positive Babinski reflexes.[doi.org]

  • Subacute Combined Degeneration of Spinal Cord

    Case Presentation: A 28‐year‐old nursing student with a history of bipolar disorder presented to Tucson Medical Center with symptoms of ataxia and bilateral lower‐extremity[shmabstracts.com] He presented acutely with tremors, diaphoresis, insomnia, ataxia (progressive over the last three months), lower extremity paresthesias, decreased somatosensory perception[em-consulte.com] […] degeneration of spinal cord ; : symmetrical manifestations Loss of vibratory sensation, tactile discrimination, and proprioception Spastic paresis Gait abnormalities (spinal ataxia[amboss.com]

  • Whipple Disease

    A 58-year-old man with dizziness and unsteady gait had a 10-year history of behavioral change, impotence, and a progressive peripheral neuropathy.[ncbi.nlm.nih.gov] Results Subject 1 A 54-year-old man presented with hypersomnia, weight gain, lower extremity weakness, dysarthria, confusion, and gait ataxia.[ajnr.org]

  • Hereditary Orotic Aciduria

    Clinical features Ataxia, chorea, and axonal polyneuropathy Cutaneous photosensitivity and multiple cancers Mental and motor retardation Microcephaly Sensorineural deafness[emedicine.medscape.com] It is characterized by extremely low plasma levels of Apo-B, as well as low levels of total cholesterol and LDL cholesterol. Table 5.[emedicine.medscape.com] Laboratory findings: Defective DNA repair after ultraviolet radiation damage Ataxia telangiectasia This progressive, recessively inherited ataxia manifests in early childhood[emedicine.medscape.com]

  • Transcobalamin 2 Deficiency

    peripheral neuropathy with pronounced anemia, Spinal degeneration, Brain atrophy, and macrocytic cells.[vitaminb12deficiency.net.au] In later stages, spasticity, extensor plantar responses, greater loss of position and vibratory sensation in the lower extremities, and ataxia emerge.[merckmanuals.com] ) Hypotonia (low muscle tone) Reduced tactile sensation Seizures Ataxia (lack of muscle control) Symptoms of paralysis Involuntary movements Concentration problems Memory[stichtingb12tekort.nl]

  • Acute Arsenic Poisoning

    In addition, non-inflammatory degenerative disease of the sensorimotor nerves (sensorimotor polyneuropathy) may advance to progressive deterioration (atrophy).[rarediseases.org] […] jerks, tremors, seizures, an impaired ability to coordinate voluntary movements (ataxia), and/or inability to stand or walk.[rarediseases.org] Some affected individuals may experience the loss of most or all of their scalp hair (alopecia); rapidly progressive and painful sensory polyneuropathy; motor neuropathy;[rarediseases.org]

  • Glutamate Formiminotransferase Deficiency

    […] characterized by severe motor retardation and progressive scoliosis.[amp.pharm.mssm.edu] […] and spasticity Paroxysmal exertion-induced dyskinesia Paroxysmal extreme pain disorder Paroxysmal kinesigenic choreathetosis Paroxysmal kinesigenic dyskinesia Paroxysmal[csbg.cnb.csic.es] […] b-cell immunodeficiency, periodic fevers, and developmental delay Lattice corneal dystrophy Type III Autosomal recessive cutis laxa type 3B Striatal necrosis, bilateral, and progressive[amp.pharm.mssm.edu]

  • Congenital Vitamin B12 Deficiency

    Complete recovery was progressively achieved over a 12-month period.[scielo.br] ) Hypotonia (low muscle tone) Reduced tactile sensation Seizures Ataxia (lack of muscle control) Symptoms of paralysis Involuntary movements Concentration problems Memory[stichtingb12tekort.nl] Diagnostic methods Diagnosis depends on blood tests that show low serum levels of cobalamin and megaloblastic anemia (decreased red blood cell count and increased mean corpuscular[orpha.net]

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