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2,180 Possible Causes for 'Eye of the Tiger' Sign on MRI, Increased Urinary Dopamine and Dopamine Metabolites (Paradoxical), Psychomotor Retardation

Did you mean: 'Eye of the Tiger' Sign on MRI, Increased Urinary Dopamine and Dopamine Metabolites (Paradoxical, Psychomotor Retardation

  • Aromatic L-Amino Acid Decarboxylase Deficiency

    […] of the tigersign on MRI.[invitae.com] These patients were born to healthy and non-consanguineous parents, and presented oculogyric crises, paroxysmal dystonic attacks, and severe psychomotor retardation since[ncbi.nlm.nih.gov] FTL PANK2 PLA2G6 WDR45 Neurodegeneration with brain iron accumulation ( NBIA ) is a group of disorders characterized by iron accumulation in the basal ganglia causing the “eye[invitae.com]

  • Hallervorden-Spatz Syndrome

    Iron deposition in conjunction with destruction of the globus pallidus gives rise to the characteristic eye-of-the-tiger sign in MRI.[ncbi.nlm.nih.gov] […] of the tiger" sign.[ncbi.nlm.nih.gov] It has been postulated that pantothenate kinase 2 mutations underlying all cases of classic Hallervorden-Spatz syndrome are always associated with the eye-of-the-tiger sign[ncbi.nlm.nih.gov]

    Missing: Increased Urinary Dopamine and Dopamine Metabolites (Paradoxical)
  • Fucosidosis

    MRI images at 6.5 years of age were reminiscent of pallidal iron deposition ("eye-of-the-tiger" sign) seen in neurodegeneration with brain iron accumulation (NBIA) disorders[ncbi.nlm.nih.gov] In type 2, patients have angiokeratoma, milder psychomotor retardation and neurologic signs, longer survival, and normal salinity in the sweat.[ncbi.nlm.nih.gov] MRI and MR spectroscopy are of substantial diagnostic value. Pallidal lesions resembling the eye-of-the-tiger sign suggest brain iron accumulation.[medlink.com]

    Missing: Increased Urinary Dopamine and Dopamine Metabolites (Paradoxical)
  • Infantile Neuroaxonal Dystrophy

    The MRI usually shows an area of hyperintensity in the medial globus pallidus that has been called the ‘eye of the tigersign but this is not pathognomonic.[disorders.eyes.arizona.edu] .: Axonic and synaptic changes in a case of psychomotor retardation: An electron microscopic study. J. Neuropath. exp.[link.springer.com] .: Axonic and synaptic changes in case of psychomotor retardation; an electron microscopic study. J. Neuropath. exp.[springerlink.com]

    Missing: Increased Urinary Dopamine and Dopamine Metabolites (Paradoxical)
  • Depression

    This is called psychomotor retardation.[health.com] Changes in Activity or Energy Level Physical Changes Caused by Depression Unexplained aches and pains Weight loss or gain Decreased or increased appetite Psychomotor agitation[verywell.com] Psychomotor agitation or retardation nearly every day. Fatigue or loss of energy nearly every day.[depression.org]

    Missing: 'Eye of the Tiger' Sign on MRI Increased Urinary Dopamine and Dopamine Metabolites (Paradoxical)
  • Endogenous Depression

    It is generally accepted that endogenous depression includes marked vegetative changes, such as loss of appetite, loss of weight, loss of sleep, psychomotor retardation or[link.springer.com] […] score, presumably measuring mainly depressive mood and psychomotor retardation.[ncbi.nlm.nih.gov] […] depression major depressive disorder characterized by signs and symptoms of psychomotor retardation, such as burdened movements and slowed, toneless speech. en·dog·e·nous[medical-dictionary.thefreedictionary.com]

    Missing: 'Eye of the Tiger' Sign on MRI Increased Urinary Dopamine and Dopamine Metabolites (Paradoxical)
  • Reactive Depression

    […] depression major depressive disorder characterized by signs and symptoms of psychomotor retardation, such as burdened movements and slowed, toneless speech. re·ac·tive de[medical-dictionary.thefreedictionary.com] “A patient who has psychomotor retardation, hypersomnia, and gaining weight is scored as having identical symptoms as another who is agitated, sleeping badly, and has weight[theatlantic.com] It is often identified with a specific symptom complex—psychomotor retardation, early morning awakening, weight loss, excessive guilt, and lack of reactivity to the environment—that[medical-dictionary.thefreedictionary.com]

    Missing: 'Eye of the Tiger' Sign on MRI Increased Urinary Dopamine and Dopamine Metabolites (Paradoxical)
  • Suicidal Depression

    Signs of depression may include the following: Psychomotor retardation or agitation, such as slowed speech, sighs, and long pauses Slowed body movements, even to the extent[emedicine.medscape.com]

    Missing: 'Eye of the Tiger' Sign on MRI Increased Urinary Dopamine and Dopamine Metabolites (Paradoxical)
  • Neurodegeneration with Brain Iron Accumulation

    Individuals with PKAN and HARP syndrome, which is considered part of the PKAN disease spectrum, show a characteristic "eye of the tiger''sign on MRI, a central region of hyperintensity[orpha.net] Analysis of the WDR45 gene revealed a novel heterozygous missense mutation in one female NBIA patient showing psychomotor retardation with secondary decline.[ncbi.nlm.nih.gov] sign in cranial MRI, this case most likely represented an idiopathic form of NBIA but atypical PKAN may be also considered.[ncbi.nlm.nih.gov]

    Missing: Increased Urinary Dopamine and Dopamine Metabolites (Paradoxical)
  • Leigh's Disease

    A 4 1/2-month-old girl suffered from psychomotor retardation, generalized hypotonia, poor feeding, hyperreflexia, nystagmus, optical atrophy and choreoathetosis from the age[ncbi.nlm.nih.gov] A two-and-a-half-year-old male child presented with recurrent attacks of intractable vomiting, psychomotor retardation since 14 months of age.[ncbi.nlm.nih.gov] The most common symptoms are generalized weakness, failure to thrive, psychomotor retardation, anorexia, muscle atrophy, absence of reflexes, and sometimes seizures.[symptoma.com]

    Missing: 'Eye of the Tiger' Sign on MRI Increased Urinary Dopamine and Dopamine Metabolites (Paradoxical)

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