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45 Possible Causes for 'Eye of the Tiger' Sign on MRI, Muscle Rigidity

  • Hallervorden-Spatz Syndrome

    A neurological examination would show evidence of muscle rigidity; weakness; and abnormal postures, movements, and tremors.[en.wikipedia.org] Iron deposition in conjunction with destruction of the globus pallidus gives rise to the characteristic eye-of-the-tiger sign in MRI.[ncbi.nlm.nih.gov] […] of the tiger" sign.[ncbi.nlm.nih.gov]

  • Juvenile Paralysis Agitans of Hunt

    It is clinically characterized by movement disorders such as muscle rigidity, akinesia and tremor.[books.google.de] Parkinsonismo precoce associado a lesões palidais de tipo "eye-of-the-tiger" "Eye-of-the-tiger" sign at MRI in a patient with early-onset parkinsonism Egberto Reis Barbosa[scielo.br] Rigidity: Stiffness of the limbs and trunk, which may increase during movement. Rigidity may produce muscle aches and pain.[medicinenet.com]

  • Neurodegeneration with Brain Iron Accumulation

    […] trunk), dysarthria (slurred or slow speech) choreoathetosis (involuntary, purposeless jerky muscle movements), muscle rigidity (uncontrolled tightness of the muscles), spasticity[ninds.nih.gov] Individuals with PKAN and HARP syndrome, which is considered part of the PKAN disease spectrum, show a characteristic "eye of the tiger''sign on MRI, a central region of hyperintensity[orpha.net] Neurologic signs include parkinsonism, abnormal postures and movements (dystonia), ataxia, muscle rigidity, spasticity, and cognitive impairment.[secure.ssa.gov]

  • X-linked Parkinsonism-Spasticity Syndrome

    Parkinson's Disease is a progressive disorder of the nervous system marked by muscle tremors, muscle rigidity, decreased mobility, stooped posture, slow voluntary movements[patientslikeme.com] T2-weighted fast spin echo (G) and T1-weighted (H) brain MRI scans from a child with PKAN demonstrating the "eye of the tiger" sign (courtesy of Susan J.[ojrd.biomedcentral.com] As in Parkinson's disease, many common symptoms may develop, including tremor; muscle rigidity or stiffness of the limbs; gradual loss of spontaneous movement, often leading[aans.org]

  • Mitochondrial Membrane Protein-Associated Neurodegeneration

    These abnormalities include unusually slow movement (bradykinesia), muscle rigidity, involuntary trembling (tremors), and an inability to hold the body upright and balanced[ghr.nlm.nih.gov] None of our pa-tients exhibited the eye of the tiger sign on T2-weighted MRI.[docslide.net] MRI showed iron deposition in the globus pallidus and substantia nigra without the eye-of-the-tiger sign, which is typical for PKAN, the most frequent form of NBIA.[push-zb.helmholtz-muenchen.de]

  • Jankovic Rivera Syndrome

    In addition to myoclonic epilepsy, they may have generalized tonic-clonic seizures (also known as grand mal seizures), which cause muscle rigidity, convulsions, and loss of[ghr.nlm.nih.gov] Pantothenate kinase 2 mutation with classic pantothenate-kinase-associated neurodegeneration without ‘eye-of-the-tigersign on MRI in a pair of siblings.[e-jmd.org] T1WI showed hyperintensity in all cases of HSS in addition to the “eye‐of‐the‐tigersign on T2WI.[doi.org]

  • McLeod Neuroacanthocytosis Syndrome

    Examples of symptoms include: rigidity in the muscles muscle spasms involuntary movements clumsiness and unsteadiness dystonia lack of muscle tone retinopathy (gradual deterioration[medic8.com] […] of the tiger" sign on MRI characteristic Pigmentary retinopathy PRNP HDL1 (OMIM 603218 ) AD Phenotype may be indistinguishable from HD.[ncbi.nlm.nih.gov] Common features include dystonia, an abnormality in muscle tone, muscular rigidity, and sudden involuntary muscle spasms (spasticity) that result in slow, stiff movements[rarediseases.org]

  • Benign Adult Familial Myoclonic Epilepsy

    In addition to seizures, symptoms may include unsteadiness, muscle rigidity, and intellectual disability.[nyulangone.org] T2 weighted brain MRI shows an ”eye of the tigersign corresponding to pallidal hypointensity with a high signal center.[neuroweb.us] Clonic seizures, which are very rare, occur primarily in young children, who experience spasms of the muscles but not tonic rigidity.[stlukes-stl.com]

  • COASY Protein-Associated Neurodegeneration

    rigidity , paraparesis, spastic and bradykinesia .[malacards.org] MRI and CT " Eye of the tiger sign " on T2 MRI (like PKAN ) associated with bilateral basal ganglia calcifications . Promoted articles (advertising)[radiopaedia.org] Muscle rigidity 0002063 Spastic tetraplegia 0002510 Toe walking Toe-walking 0040083 Showing of 25 Last updated: 12/1/2018 If you need medical advice, you can look for doctors[rarediseases.info.nih.gov]

  • Beta-Propeller Protein-Associated Neurodegeneration

    This type of seizure affects the entire body, causing muscle rigidity, convulsions, and loss of consciousness.[elbiruniblogspotcom.blogspot.no] These deposits appeared as dark spots on the MRI, which became known as the “eye of the tigersign.[epilepsygenetics.net] Dystonia is a condition characterized by involuntary, sustained muscle contractions. In BPAN , the dystonia often starts in the arms.[ghr.nlm.nih.gov]

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