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52 Possible Causes for 'Eye of the Tiger' Sign on MRI, Pediatric Disorder

  • Hallervorden-Spatz Syndrome

    […] treatments and interventions Covers neurological, neuropsychiatric, and neuromedical disorders across the lifespan (pediatric, adult, and geriatric populations) Includes[] Iron deposition in conjunction with destruction of the globus pallidus gives rise to the characteristic eye-of-the-tiger sign in MRI.[] Molecular & Medical Genetics, Pediatrics, and Neurology, Oregon Health & Science University, Portland, Oregon, USA Correspondence to Susan J.[]

  • Juvenile Paralysis Agitans of Hunt

    […] see Chap. 37 ), birth injuries, epilepsy, disharmonies of development, and learning disabilities (see Chap. 27 )—make up the bulk of the clinical problems with which the pediatric[] Parkinsonismo precoce associado a lesões palidais de tipo "eye-of-the-tiger" "Eye-of-the-tiger" sign at MRI in a patient with early-onset parkinsonism Egberto Reis Barbosa[] 2016 2017 2018 2019 Billable/Specific Code Pediatric Dx (0-17 years) Applicable To Dementia infantilis Disintegrative psychosis Heller's syndrome Symbiotic psychosis Type[]

  • Canavan Disease

    Disease Focus: Genetic Disorder Neurological Disorders Pediatrics Grant Application Details Application Title: Developing a therapeutic candidate for Canavan disease using[] A brain MRI at four years of age showed low-signal intensity rings surrounding central hyperintense T2-weighted signal in bilateral globus pallidi, (“eye of the tigersign[] Pediatric Radiology: The Requisites. 4th ed. Philadelphia, PA: Elsevier; 2017:chap 8. Elitt CM, Volpe JJ. Degenerative disorders of the newborn.[]

  • Fucosidosis

    Pediatr Radiol 2007;37:1050-2. 8. Sanklecha MU, Kher A, Naik GG, Bharucha BA, Mahajan P. Storage disorders presenting like mucopolysaccharidosis.[] MRI images at 6.5 years of age were reminiscent of pallidal iron deposition ("eye-of-the-tiger" sign) seen in neurodegeneration with brain iron accumulation (NBIA) disorders[] MRI and MR spectroscopy are of substantial diagnostic value. Pallidal lesions resembling the eye-of-the-tiger sign suggest brain iron accumulation.[]

  • Valinemia

    All patients have the 'eye of the tiger' sign on brain MRI ( Hayflick et al., 2003 ; Pellecchia et al., 2005 ).[] Kumar et al. (2006) noted that the 'eye of the tiger' sign is not pathognomonic for PANK2 mutations.[] They reported 2 unrelated adult patients with cognitive dysfunction who had the characteristic sign on MRI but did not have mutations in the PANK2 gene.[]

  • Infantile Neuroaxonal Dystrophy

    This book provides an update on pediatric neurological disorders with cerebellar involvement.[] The MRI usually shows an area of hyperintensity in the medial globus pallidus that has been called the ‘eye of the tigersign but this is not pathognomonic.[] […] treatments and interventions Covers neurological, neuropsychiatric, and neuromedical disorders across the lifespan (pediatric, adult, and geriatric populations) Includes[]

  • Neurodegeneration with Brain Iron Accumulation

    The presentation of NBIA overlaps with the more common adult movement disorders and pediatric neurometabolic conditions, and a high index of suspicion is required to make[] Individuals with PKAN and HARP syndrome, which is considered part of the PKAN disease spectrum, show a characteristic "eye of the tiger''sign on MRI, a central region of hyperintensity[] ., professor of molecular and medical genetics, pediatrics and neurology in the OHSU School of Medicine.[]

  • Aromatic L-Amino Acid Decarboxylase Deficiency

    METHOD: Clinical and biochemical data of 78 patients with AADC deficiency were tabulated in a database of pediatric neurotransmitter disorders (JAKE).[] […] of the tigersign on MRI.[] The diagnosis of aromatic L-amino acid decarboxylase (AADC) deficiency, one of the pediatric neurotransmitter disorders, is classically made with plasma enzyme level or cerebrospinal[]

  • X-linked Parkinsonism-Spasticity Syndrome

    Center for Human Genetics and is Director of the Rare Brain Disorders Program (Clinic and Laboratory).[] T2-weighted fast spin echo (G) and T1-weighted (H) brain MRI scans from a child with PKAN demonstrating the "eye of the tiger" sign (courtesy of Susan J.[] T2 weighted brain MRI shows an ”eye of the tigersign corresponding to pallidal hypointensity with a high signal center.[]

  • McLeod Neuroacanthocytosis Syndrome

    Michael E Miller, Functional Leukocyte Disorders, Pediatric Annals, 10.3928/0090-4481-19790601-05, 8, 6, (10-24), (1979).[] […] of the tiger" sign on MRI characteristic Pigmentary retinopathy PRNP HDL1 (OMIM 603218 ) AD Phenotype may be indistinguishable from HD.[] Pantothenate kinase 2 mutation with classic pantothenate-kinase-associated neurodegeneration without ‘eye-of-the-tigersign on MRI in a pair of siblings.[]

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