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52 Possible Causes for 'Eye of the Tiger' Sign on MRI, Pediatric Disorder

  • Hallervorden-Spatz Syndrome

    […] treatments and interventions Covers neurological, neuropsychiatric, and neuromedical disorders across the lifespan (pediatric, adult, and geriatric populations) Includes[books.google.com] Iron deposition in conjunction with destruction of the globus pallidus gives rise to the characteristic eye-of-the-tiger sign in MRI.[ncbi.nlm.nih.gov] Molecular & Medical Genetics, Pediatrics, and Neurology, Oregon Health & Science University, Portland, Oregon, USA Correspondence to Susan J.[journals.lww.com]

  • Juvenile Paralysis Agitans of Hunt

    […] see Chap. 37 ), birth injuries, epilepsy, disharmonies of development, and learning disabilities (see Chap. 27 )—make up the bulk of the clinical problems with which the pediatric[accessmedicine.mhmedical.com] Parkinsonismo precoce associado a lesões palidais de tipo "eye-of-the-tiger" "Eye-of-the-tiger" sign at MRI in a patient with early-onset parkinsonism Egberto Reis Barbosa[scielo.br] 2016 2017 2018 2019 Billable/Specific Code Pediatric Dx (0-17 years) Applicable To Dementia infantilis Disintegrative psychosis Heller's syndrome Symbiotic psychosis Type[icd10data.com]

  • Canavan Disease

    Disease Focus: Genetic Disorder Neurological Disorders Pediatrics Grant Application Details Application Title: Developing a therapeutic candidate for Canavan disease using[cirm.ca.gov] A brain MRI at four years of age showed low-signal intensity rings surrounding central hyperintense T2-weighted signal in bilateral globus pallidi, (“eye of the tigersign[ncbi.nlm.nih.gov] Pediatric Radiology: The Requisites. 4th ed. Philadelphia, PA: Elsevier; 2017:chap 8. Elitt CM, Volpe JJ. Degenerative disorders of the newborn.[nlm.nih.gov]

  • Fucosidosis

    Pediatr Radiol 2007;37:1050-2. 8. Sanklecha MU, Kher A, Naik GG, Bharucha BA, Mahajan P. Storage disorders presenting like mucopolysaccharidosis.[pediatricneurosciences.com] MRI images at 6.5 years of age were reminiscent of pallidal iron deposition ("eye-of-the-tiger" sign) seen in neurodegeneration with brain iron accumulation (NBIA) disorders[ncbi.nlm.nih.gov] MRI and MR spectroscopy are of substantial diagnostic value. Pallidal lesions resembling the eye-of-the-tiger sign suggest brain iron accumulation.[medlink.com]

  • Valinemia

    All patients have the 'eye of the tiger' sign on brain MRI ( Hayflick et al., 2003 ; Pellecchia et al., 2005 ).[mendelian.co] Kumar et al. (2006) noted that the 'eye of the tiger' sign is not pathognomonic for PANK2 mutations.[mendelian.co] They reported 2 unrelated adult patients with cognitive dysfunction who had the characteristic sign on MRI but did not have mutations in the PANK2 gene.[mendelian.co]

  • Infantile Neuroaxonal Dystrophy

    This book provides an update on pediatric neurological disorders with cerebellar involvement.[books.google.com] The MRI usually shows an area of hyperintensity in the medial globus pallidus that has been called the ‘eye of the tigersign but this is not pathognomonic.[disorders.eyes.arizona.edu] […] treatments and interventions Covers neurological, neuropsychiatric, and neuromedical disorders across the lifespan (pediatric, adult, and geriatric populations) Includes[books.google.com]

  • Neurodegeneration with Brain Iron Accumulation

    The presentation of NBIA overlaps with the more common adult movement disorders and pediatric neurometabolic conditions, and a high index of suspicion is required to make[ncbi.nlm.nih.gov] Individuals with PKAN and HARP syndrome, which is considered part of the PKAN disease spectrum, show a characteristic "eye of the tiger''sign on MRI, a central region of hyperintensity[orpha.net] ., professor of molecular and medical genetics, pediatrics and neurology in the OHSU School of Medicine.[news-medical.net]

  • Aromatic L-Amino Acid Decarboxylase Deficiency

    METHOD: Clinical and biochemical data of 78 patients with AADC deficiency were tabulated in a database of pediatric neurotransmitter disorders (JAKE).[ncbi.nlm.nih.gov] […] of the tigersign on MRI.[invitae.com] The diagnosis of aromatic L-amino acid decarboxylase (AADC) deficiency, one of the pediatric neurotransmitter disorders, is classically made with plasma enzyme level or cerebrospinal[ncbi.nlm.nih.gov]

  • X-linked Parkinsonism-Spasticity Syndrome

    Center for Human Genetics and is Director of the Rare Brain Disorders Program (Clinic and Laboratory).[books.google.com] T2-weighted fast spin echo (G) and T1-weighted (H) brain MRI scans from a child with PKAN demonstrating the "eye of the tiger" sign (courtesy of Susan J.[ojrd.biomedcentral.com] T2 weighted brain MRI shows an ”eye of the tigersign corresponding to pallidal hypointensity with a high signal center.[neuroweb.us]

  • McLeod Neuroacanthocytosis Syndrome

    Michael E Miller, Functional Leukocyte Disorders, Pediatric Annals, 10.3928/0090-4481-19790601-05, 8, 6, (10-24), (1979).[doi.org] […] of the tiger" sign on MRI characteristic Pigmentary retinopathy PRNP HDL1 (OMIM 603218 ) AD Phenotype may be indistinguishable from HD.[ncbi.nlm.nih.gov] Pantothenate kinase 2 mutation with classic pantothenate-kinase-associated neurodegeneration without ‘eye-of-the-tigersign on MRI in a pair of siblings.[e-jmd.org]

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