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35 Possible Causes for 'Eye of the Tiger' Sign on MRI, Resting Tremor

  • X-linked Parkinsonism-Spasticity Syndrome

    tremor .[malacards.org] T2-weighted fast spin echo (G) and T1-weighted (H) brain MRI scans from a child with PKAN demonstrating the "eye of the tiger" sign (courtesy of Susan J.[ojrd.biomedcentral.com] Format Definition A syndrome characterized by parkinsonian features, such as cogwheel rigidity, resting tremor and bradykinesia, and variably penetrant spasticity.[uniprot.org]

  • Hallervorden-Spatz Syndrome

    […] arm and resting tremor in upper extremities.[ncbi.nlm.nih.gov] Iron deposition in conjunction with destruction of the globus pallidus gives rise to the characteristic eye-of-the-tiger sign in MRI.[ncbi.nlm.nih.gov] At the age of 22, she suffered from akinesia, resting tremor, and rigidity.[ncbi.nlm.nih.gov]

  • Juvenile Paralysis Agitans of Hunt

    Another disorder in which a resting tremor is one of the main symptoms, accompanied by slowness and poverty of movement, muscular rigidity, and postural instability is Parkinson's[encyclopedia2.thefreedictionary.com] Parkinsonismo precoce associado a lesões palidais de tipo "eye-of-the-tiger" "Eye-of-the-tiger" sign at MRI in a patient with early-onset parkinsonism Egberto Reis Barbosa[scielo.br] Parkinson disease (PD) , also known as idiopathic parkinsonism , is a neurodegenerative disease and movement disorder characterized by resting tremor, rigidity and hypokinesia[radiopaedia.org]

  • Senile Chorea

    Action Tremor Description Tremor when skeletal muscle is at rest.[stanfordmedicine25.stanford.edu] Her MRI did not show the typical “eye of the tigersign or pronounced low signal in the globus pallidus without the additional inserted bright signal that has now been well[jnnp.bmj.com] The frequency of the tremor is in the range of 4–12 Hz, which is faster than the rest tremor of PD.[geriatricscareonline.org]

  • Neurodegeneration with Brain Iron Accumulation

    At the age of 22, she suffered from akinesia, resting tremor, and rigidity.[ncbi.nlm.nih.gov] Individuals with PKAN and HARP syndrome, which is considered part of the PKAN disease spectrum, show a characteristic "eye of the tiger''sign on MRI, a central region of hyperintensity[orpha.net] The most common features of parkinsonism in these individuals are bradykinesia, resting tremor, rigidity, and postural instability.[ncbi.nlm.nih.gov]

  • Jankovic Rivera Syndrome

    Sometimes the symptoms of Parkinson’s disease can be very obvious, such as a resting tremor.[movementdisorders.ufhealth.org] Pantothenate kinase 2 mutation with classic pantothenate-kinase-associated neurodegeneration without ‘eye-of-the-tigersign on MRI in a pair of siblings.[e-jmd.org] T1WI showed hyperintensity in all cases of HSS in addition to the “eye‐of‐the‐tigersign on T2WI.[doi.org]

  • Basal Ganglia Lesion

    ., extrapyramidal) injury involve the following involuntary movement disorders: Parkinsonism – combination of resting tremor, rigidity, bradykinesia/akinesia, and postural[brainaacn.org] On MRI, the typical “eye-of-the-tigersign is characterized by bilateral symmetric hyperintense signal of the anterior medial globus pallidus with surrounding hypointensity[em-consulte.com] Low-amplitude bilateral upper limb resting tremor, bradykinesia and ataxic gait was present.[jneuro.com]

  • Benign Adult Familial Myoclonic Epilepsy

    tremor?[researchmap.jp] T2 weighted brain MRI shows an ”eye of the tigersign corresponding to pallidal hypointensity with a high signal center.[neuroweb.us] Jerks occur at rest in prolonged runs. In addition, the majority of patients have myoclonic and absence seizures, as well as episodes of myoclonic status.[clinicalgate.com]

  • Early-Onset Cerebellar Ataxia

    tremor postural instability not caused by primary visual, vestibular, cerebellar or proprioceptive dysfunction Step 2 Exclusion criteria for Parkinson's disease... ‏[books.google.com] T2 weighted brain MRI shows an ”eye of the tigersign corresponding to pallidal hypointensity with a high signal center.[neuroweb.us] […] level, history of concomittent treatment-CPZ Hemodialysis and Intensive care management Amiadarone Cerebellar ataxia, Peripheral neuropathy,Myoclonus, encephalopathy and rest[slideshare.net]

  • Degenerative Disorder

    Degenerative and age-related disorders, such as Parkinson’s disease, can affect the central nervous system causing postural instability, tremors at rest, stiffness and a general[drlemmobraincentre.com] […] of the tigersign on MRI brains scan and PANK2 mutations; secondly, a group of clinically atypical cases which did not have PANK2 mutations nor the “eye of the tiger sign[jmg.bmj.com] ” but did have hypodensity in the globus pallidus on T2 weighted MRI brain scans, cerebellar atrophy, and often evidence of iron deposition in the red nucleus and dentate[jmg.bmj.com]

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