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42 Possible Causes for 'Eye of the Tiger' Sign on MRI, Slow Speech

  • Hallervorden-Spatz Syndrome

    These abnormalities progressed over the years with slowing of voluntary movements, rigidity of limbs and dystonic posturing. Speech was slurred.[jpgmonline.com] Iron deposition in conjunction with destruction of the globus pallidus gives rise to the characteristic eye-of-the-tiger sign in MRI.[ncbi.nlm.nih.gov] Intermediate forms manifest onset in first decade with slow progression or onset in second decade with rapid progression.[genecards.org]

  • Juvenile Paralysis Agitans of Hunt

    speech rate -cranial polyneuropathy presenting as recurrent unilateral painful ophthalmoplegia -CN 2, 3, 4, V1, and 6 may be involved -tendency for spontaneous resolution[cram.com] Parkinsonismo precoce associado a lesões palidais de tipo "eye-of-the-tiger" "Eye-of-the-tiger" sign at MRI in a patient with early-onset parkinsonism Egberto Reis Barbosa[scielo.br] , quieter speech, and monotone voice Urinary frequency/urgency SLIDESHOW Parkinson's Disease: Symptoms, Causes, Stages, Treatment See Slideshow What causes Parkinson's disease[medicinenet.com]

  • Alcoholic Cerebellar Degeneration

    Slowed and slurred speech 5. Nystagmus (quick, small actions of the eyes.) Is there a known treatment for Alcoholic Cerebellar Degeneration?[hncmag.com] T2 weighted brain MRI shows an ”eye of the tigersign corresponding to pallidal hypointensity with a high signal center.[neuroweb.us] A 41 yo female with slow progressive ataxia, slurred speech since last 15 years. Truncal ataxia on neurological examination.[neuroradiologycases.com]

  • Senile Chorea

    Modest improvements were seen in symptoms including: motor coordination, speech intelligibility and vocal intensity, bradykinesia (slow movement), emotional functions, activities[goodearthnaturalfoods.com] Her MRI did not show the typical “eye of the tigersign or pronounced low signal in the globus pallidus without the additional inserted bright signal that has now been well[jnnp.bmj.com]

  • Subacute Cerebellar Degeneration

    Get the patient to stick his/her tongue out and move it from side to side (movement slowed).[patient.info] T2 weighted brain MRI shows an ”eye of the tigersign corresponding to pallidal hypointensity with a high signal center.[neuroweb.us] Ask the patient to repeat "baby hippopotamus" - look for dysarthria and abnormal speech rhythm and syllable emphasis.[patient.info]

  • Neurodegeneration with Brain Iron Accumulation

    […] trunk), dysarthria (slurred or slow speech) choreoathetosis (involuntary, purposeless jerky muscle movements), muscle rigidity (uncontrolled tightness of the muscles), spasticity[ninds.nih.gov] Individuals with PKAN and HARP syndrome, which is considered part of the PKAN disease spectrum, show a characteristic "eye of the tiger''sign on MRI, a central region of hyperintensity[orpha.net] Others may present with speech delay and autistic features, which may remain as the only evidence of disease for a year or more, given the slow progression of atypical NAD[ncbi.nlm.nih.gov]

  • X-linked Parkinsonism-Spasticity Syndrome

    People with PSP experience a gradual loss of specific brain cells, causing slowing of movement and reduced control of walking, balance, swallowing, speech and eye movement[aans.org] T2-weighted fast spin echo (G) and T1-weighted (H) brain MRI scans from a child with PKAN demonstrating the "eye of the tiger" sign (courtesy of Susan J.[ojrd.biomedcentral.com] T2 weighted brain MRI shows an ”eye of the tigersign corresponding to pallidal hypointensity with a high signal center.[neuroweb.us]

  • McLeod Neuroacanthocytosis Syndrome

    […] the expression of Kx red blood cell antigen) Symptoms of Huntington’s disease-like 2 Symptoms include: dystonia chorea exaggerated reflexes (known as hyperreflexia) very slow[medic8.com] […] of the tiger" sign on MRI characteristic Pigmentary retinopathy PRNP HDL1 (OMIM 603218 ) AD Phenotype may be indistinguishable from HD.[ncbi.nlm.nih.gov] , tremors and low speech.[rarediseases.org]

  • Mitochondrial Membrane Protein-Associated Neurodegeneration

    […] surgeons, and neurosurgeons is essential.PrognosisThe progression of MPAN is usually slow and may lead to loss of independent ambulation due to spasticity, dystonia, and[malacards.org] None of our pa-tients exhibited the eye of the tiger sign on T2-weighted MRI.[docslide.net] MRI showed iron deposition in the globus pallidus and substantia nigra without the eye-of-the-tiger sign, which is typical for PKAN, the most frequent form of NBIA.[push-zb.helmholtz-muenchen.de]

  • Basal Ganglia Lesion

    Dysarthria: Action Myoclonus Occasional voice arrests Slow rate, imprecision, marked irregularity of AMR’s with increased rate Awareness of imprecise speech and reluctance[ucs.louisiana.edu] On MRI, the typical “eye-of-the-tigersign is characterized by bilateral symmetric hyperintense signal of the anterior medial globus pallidus with surrounding hypointensity[em-consulte.com] Case 2 A 46-year-old male patient presented with sudden onset of slurred speech, slow gait and loss of balance. His medical history revealed insulin resistance and ESRD.[jneuro.com]

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