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42 Possible Causes for 'Eye of the Tiger' Sign on MRI, Slow Speech

  • Hallervorden-Spatz Syndrome

    These abnormalities progressed over the years with slowing of voluntary movements, rigidity of limbs and dystonic posturing. Speech was slurred.[] Iron deposition in conjunction with destruction of the globus pallidus gives rise to the characteristic eye-of-the-tiger sign in MRI.[] Intermediate forms manifest onset in first decade with slow progression or onset in second decade with rapid progression.[]

  • Juvenile Paralysis Agitans of Hunt

    speech rate -cranial polyneuropathy presenting as recurrent unilateral painful ophthalmoplegia -CN 2, 3, 4, V1, and 6 may be involved -tendency for spontaneous resolution[] Parkinsonismo precoce associado a lesões palidais de tipo "eye-of-the-tiger" "Eye-of-the-tiger" sign at MRI in a patient with early-onset parkinsonism Egberto Reis Barbosa[] , quieter speech, and monotone voice Urinary frequency/urgency SLIDESHOW Parkinson's Disease: Symptoms, Causes, Stages, Treatment See Slideshow What causes Parkinson's disease[]

  • Alcoholic Cerebellar Degeneration

    Slowed and slurred speech 5. Nystagmus (quick, small actions of the eyes.) Is there a known treatment for Alcoholic Cerebellar Degeneration?[] T2 weighted brain MRI shows an ”eye of the tigersign corresponding to pallidal hypointensity with a high signal center.[] A 41 yo female with slow progressive ataxia, slurred speech since last 15 years. Truncal ataxia on neurological examination.[]

  • Senile Chorea

    Modest improvements were seen in symptoms including: motor coordination, speech intelligibility and vocal intensity, bradykinesia (slow movement), emotional functions, activities[] Her MRI did not show the typical “eye of the tigersign or pronounced low signal in the globus pallidus without the additional inserted bright signal that has now been well[]

  • Subacute Cerebellar Degeneration

    Get the patient to stick his/her tongue out and move it from side to side (movement slowed).[] T2 weighted brain MRI shows an ”eye of the tigersign corresponding to pallidal hypointensity with a high signal center.[] Ask the patient to repeat "baby hippopotamus" - look for dysarthria and abnormal speech rhythm and syllable emphasis.[]

  • Neurodegeneration with Brain Iron Accumulation

    […] trunk), dysarthria (slurred or slow speech) choreoathetosis (involuntary, purposeless jerky muscle movements), muscle rigidity (uncontrolled tightness of the muscles), spasticity[] Individuals with PKAN and HARP syndrome, which is considered part of the PKAN disease spectrum, show a characteristic "eye of the tiger''sign on MRI, a central region of hyperintensity[] Others may present with speech delay and autistic features, which may remain as the only evidence of disease for a year or more, given the slow progression of atypical NAD[]

  • X-linked Parkinsonism-Spasticity Syndrome

    People with PSP experience a gradual loss of specific brain cells, causing slowing of movement and reduced control of walking, balance, swallowing, speech and eye movement[] T2-weighted fast spin echo (G) and T1-weighted (H) brain MRI scans from a child with PKAN demonstrating the "eye of the tiger" sign (courtesy of Susan J.[] T2 weighted brain MRI shows an ”eye of the tigersign corresponding to pallidal hypointensity with a high signal center.[]

  • McLeod Neuroacanthocytosis Syndrome

    […] the expression of Kx red blood cell antigen) Symptoms of Huntington’s disease-like 2 Symptoms include: dystonia chorea exaggerated reflexes (known as hyperreflexia) very slow[] […] of the tiger" sign on MRI characteristic Pigmentary retinopathy PRNP HDL1 (OMIM 603218 ) AD Phenotype may be indistinguishable from HD.[] , tremors and low speech.[]

  • Mitochondrial Membrane Protein-Associated Neurodegeneration

    […] surgeons, and neurosurgeons is essential.PrognosisThe progression of MPAN is usually slow and may lead to loss of independent ambulation due to spasticity, dystonia, and[] None of our pa-tients exhibited the eye of the tiger sign on T2-weighted MRI.[] MRI showed iron deposition in the globus pallidus and substantia nigra without the eye-of-the-tiger sign, which is typical for PKAN, the most frequent form of NBIA.[]

  • Basal Ganglia Lesion

    Dysarthria: Action Myoclonus Occasional voice arrests Slow rate, imprecision, marked irregularity of AMR’s with increased rate Awareness of imprecise speech and reluctance[] On MRI, the typical “eye-of-the-tigersign is characterized by bilateral symmetric hyperintense signal of the anterior medial globus pallidus with surrounding hypointensity[] Case 2 A 46-year-old male patient presented with sudden onset of slurred speech, slow gait and loss of balance. His medical history revealed insulin resistance and ESRD.[]

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