Facial Angiofibroma: Causes & Reasons

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Possible Causes for Facial Angiofibroma

Tuberous Sclerosis

BACKGROUND/OBJECTIVES: Tuberous sclerosis complex (TSC) is a genetic disorder and facial angiofibromas are disfiguring facial lesions. [ncbi.nlm.nih.gov]

The introduction of topical rapamycin marked a turning point for treatment of facial angiofibromas; however, the lack of a standardized formulation, limited insurance coverage [ncbi.nlm.nih.gov]

Facial angiofibromas consist of blood vessels and fibrous tissue. [nejm.org]

Angiomyolipoma

Before referral, the patient had gone most of her life without a definite diagnosis of TSC despite visually-prominent signs such as forehead plaques, facial angiofibromas, [ncbi.nlm.nih.gov]

angiofibromas, cortical tubers, subependmal nodules, giant cell astrocytomas, cardiac rhabdomyomas, lymphagniomyomatosis, and renal angiomyolipomas. 1 Angiomyolipomas (AML [appliedradiology.com]

angiofibromas, cortical tubers, subependmal nodules, giant cell astrocytomas, cardiac rhabdomyomas, lymphagniomyomatosis, and renal angiomyolipomas.1 Angiomyolipomas (AML [appliedradiology.com]

Subungual Fibroma

First left-right comparative study of topical rapamycin vs. vehicle for facial angiofibromas in patients with tuberous sclerosis complex. [jamanetwork.com]

Raised facial angiofibromas can be treated at any age. [tsalliance.org]

Skin lesions, particularly facial angiofibromas, may be psychologically distressing for some patients. [dermnetnz.org]

Multiple Endocrine Neoplasia

[…] lipomas, facial angiofibromas, medullary thyroid cancers, and phaeochromocytomas. [bestpractice.bmj.com]

Collagenomas and facial angiofibromas • Collagenomas >70 % cases – multiple, skin coloured cutaneous nodules. [slideshare.net]

[…] hormone, TSH, and/or prolactin), enteropancreatic neuroendocrine tumours (which may affect the profiles of gastrin, insulin, glucagon, and/or vasoactive intestinal protein), facial [bestpractice.bmj.com]

Angiofibroma

Picture of Angiofibroma (Facial) Angiofibromas are benign, vascular tumors that most often occur in young, adolescent males on the head and neck. [emedicinehealth.com]

Picture of Angiofibroma (Facial) Angiofibroma is a descriptive term for a group of lesions with different clinical presentations but with the same histopathology. [medicinenet.com]

Topical podophyllin has been reported in one case as improving facial angiofibromas. [dermatologyadvisor.com]

Multiple Endocrine Neoplasia Type 1

Collagenomas and facial angiofibromas • Collagenomas >70 % cases – multiple, skin coloured cutaneous nodules. [slideshare.net]

New technique using combined pulsed dye laser and fractional resurfacing for treating facial angiofibromas in tuberous sclerosis. [emedicine.medscape.com]

The patient is a 28-year-old man who was referred to the dermatology department for evaluation and removal of skins lesions, later confirmed by biopsy to be facial angiofibromas [ncbi.nlm.nih.gov]

Multiple Endocrine Neoplasia Type 4

New technique using combined pulsed dye laser and fractional resurfacing for treating facial angiofibromas in tuberous sclerosis. [emedicine.medscape.com]

angiofibromas – 70-85% of patients Lipomas – 30% of patients Malignant melanoma Central nervous system tumors Meningiomas Ependymomas Muscle tumors Leiomyomas MEN2 Epidemiology [arupconsult.com]

These tumors can include: facial angiofibromas, which are tumors of blood vessels and fibrous tissue collagenomas, which are flesh-colored tumors on the skin lipomas, which [cancer.net]

Birt-Hogg-Dubé Syndrome

This report describes multiple facial angiofibromas as the predominant initial manifestation of BHDS. [ncbi.nlm.nih.gov]

Multiple facial angiofibromas. Colonic polyps and colonic adenocarcinoma. Medullary thyroid carcinoma. [patient.info]

Multiple facial angiofibromas: a cutaneous manifestation of Birt-Hogg-Dubé syndrome. J Am Acad Dermatol. 2005 Aug. 53(2 Suppl 1):S108-11. [Medline]. [emedicine.com]

Rhabdomyoma of the Myocardium

angiofibroma 2 Heart murmur West syndrome Cortical tubers Hypomelanotic maculae No Sister with language disorders Multiple rhabdomyomas Psychomotor delay Facial angiofibroma [bmccardiovascdisord.biomedcentral.com]

angiofibromas. [emedicine.medscape.com]

Physical signs revealed facial angiofibromas, hypomelanotic macules in lower abdomen and periungal fibromas in the left thumb. [mjdrdypu.org]

Subependymal Giant Cell Astrocytoma

Female teenager aged 17, diagnosed at 3 years of age with tuberous sclerosis complex, with seizures and facial angiofibromas. [ascopubs.org]

An 11-year-old male presented with subependymal giant cell astrocytoma (SEGA) without other manifestations of tuberous sclerosis such as facial angiofibroma, epilepsy, or [ncbi.nlm.nih.gov]

Skin manifestations like shagreen patches were present in two, facial angiofibromas in three, periungal fibromas in two, hypopigmented macules in two and ash-leaf spot in [ncbi.nlm.nih.gov]

Trichofolliculoma

Multiple facial angiofibromas: a cutaneous manifestation of Birt-Hogg-Dube syndrome. [journals.lww.com]

Hamartoma of the Central Nervous System

Vogt's Triad= classical diagnostic triad < 50% of patients Seizures (80%) Mental retardation Facial angiofibromas (See diagnostic criteria from TSC Alliance site) Management [pedclerk.bsd.uchicago.edu]

The most frequent major criteria were hypomelanotic macules (97.3%), facial angiofibromas (56%) and cortical tuberomas (54.1%). [ncbi.nlm.nih.gov]

Ash-leaf spot. http://universitipetronas.hostoi.com/ACP%20Medicine/02.01.htm Facial hamartomas. http://www.aocd.org/? [pedclerk.bsd.uchicago.edu]

Pancreatic Polypeptide Tumor

Clinically, these lesions appeared to be facial angiofibromas. Brain MRI was normal. [hccpjournal.biomedcentral.com]

These tumors can include: facial angiofibroma, which is a tumor of blood vessels and fibrous tissue collagenoma, which is a flesh-colored tumor on the skin lipoma, which is [cancer.net]

They also can develop distinctive lesions of the skin (hypomelanotic macules and facial angiofibromas), kidney (angiomyolipomas), lungs (lymphangioleiomatosis), heart (rhabdomyomas [pathology.jhu.edu]

Renal Fibroma

Adenoma sebaceum (facial angiofibromas) are small, reddish nodules that appear on the cheeks and nose, beginning around age four. [patient.info]

angiofibromas should remind the physicians TS. [revistanefrologia.com]

Diagnostic features of TSC Major features Minor features Facial angiofibroma Dental enamel pits Periungual fibroma Hamartomatous rectal polyps Hypopigmented macules (>3) Bone [academic.oup.com]

Pulmonary Lymphangioleiomyomatosis

Our patient also had stigmata of tuberous sclerosis complex (TSC), including facial angiofibromas and renal angiomyolipoma. [mayoclinic.pure.elsevier.com]

Renal Angiomyolipoma

angiofibromas, cortical tubers, subependmal nodules, giant cell astrocytomas, cardiac rhabdomyomas, lymphagniomyomatosis, and renal angiomyolipomas. 1 Angiomyolipomas (AML [appliedradiology.com]

Ocular lesions include those of the eyelids which often appear in early childhood along with other facial angiofibromas (formerly called adenoma sebaceum). [disorders.eyes.arizona.edu]

A 26-year-old woman with a clinical diagnosis of tuberous sclerosis complex, presenting the classical triad of seizures, mental retardation, and facial angiofibromas and reporting [circ.ahajournals.org]

Tuberous Sclerosis Type 2

The facial papules were angiofibromas, confirming the clinical presentation of tuberous sclerosis complex. [content.sciendo.com]

Abstract Tuberous sclerosis is an autosomal dominant genetic disorder that is characterized by epilepsy, mental retardation and facial angiofibromas. [ncbi.nlm.nih.gov]

Topical rapamycin: a novel approach to facial angiofibromas in tuberous sclerosis. [scielo.br]

Tuberous Sclerosis Type 1

angiofibromas caused by tuberous sclerosis" by Herbert L. [youtube.com]

The facial papules were angiofibromas, confirming the clinical presentation of tuberous sclerosis complex. [content.sciendo.com]

Abstract Tuberous sclerosis is an autosomal dominant genetic disorder that is characterized by epilepsy, mental retardation and facial angiofibromas. [ncbi.nlm.nih.gov]

Samson-Gardner Syndrome

angiofibromas and collagenomas, and thymic, gastric, and bronchial carcinoids also occur. [en.wikipedia.org]

[…] anterior pituitary (15-90% of cases). [17] Other endocrine and non-endocrine neoplasms including adrenocortical and thyroid tumors, visceral and cutaneous lipomas, meningiomas, facial [en.wikipedia.org]

Juvenile Colloid Milium

A clinical suspicion of facial angiofibromas associated with tuberous sclerosis complex has been raised and, because of the lack of additional clinical features required to [ncbi.nlm.nih.gov]

Trichodiscoma

angiofibromas. [humpath.com]

Multiple facial angiofibromas. Colonic polyps and colonic adenocarcinoma. Medullary thyroid carcinoma. [patient.info]

[…] parathyroid adenomas, flecked chorioretinopathy, bullous emphysema, lipomas, angiolipomas, parotid oncocytomas, multiple oral mucosal papules, neural tissue tumors, and multiple facial [humpath.com]

Enamel Hypoplasia - Cataracts - Aqueductal Stenosis

Cutaneous lesions include adenoma sebaceum (facial angiofibroma), "ash leaf-shaped" hypopigmented macules is very common (best seen under ultraviolet light with a Wood’s lamp [sites.google.com]

Facial angiofibromas (adenoma sebaceum) consist of vascular and connective tissue elements. [clinicalgate.com]

Facial angiofibromas on an adolescent boy with tuberous sclerosis. Figure 4. Ungual fibroma on the fifth digit of a teenager with tuberous sclerosis Eye. [healio.com]

Hereditary Multiple Trichodiscomas

angiofibromas. [ispub.com]

Multiple facial angiofibromas: a cutaneous manifestation of Birt-Hogg-Dubé syndrome. J Am Acad Dermatol. 2005;53(2 Suppl 1):S108-11. [rarediseases.org]

Multiple facial angiofibromas. Colonic polyps and colonic adenocarcinoma. Medullary thyroid carcinoma. [patient.info]

Cerebellar Vermis Aplasia with Associated Features Suggesting Smith-Lemli-Opitz Syndrome and Meckel Syndrome

Tuberous sclerosis Other names Tuberous sclerosis complex (TSC), Bourneville disease A case of tuberous sclerosis showing facial angiofibromas in characteristic butterfly [en.wikipedia.org]

tuberous sclerosis Approved sirolimus facial angiofibromas, tuberous sclerosis Approved sirolimus facial angiofibromas, tuberous sclerosis Approved sirolimus facial angiofibromas [pharmac.govt.nz]

Extrarenal manifestations of TS include mental retardation, epilepsy, facial angiofibromas, dermatologic findings (shagreen patch, hypomelanotic macules), retinal hamartoma [hawaii.edu]

Fibular Dimelia-Diplopodia Syndrome

angiofibromas/Koenen tumors Follicular/conjunctival hamartomas Pedunculated skin lesions Subcutaneous nodules/lipomas/tumefaction/swelling Warts/papillomas Xanthomas/lipomas [readbag.com]

[…] hyperseborrhea/seborrheic dermatitis Shagreen patch Skin hypoplasia/aplasia/atrophy Skin photosensitivity Skin tumours/lumps/epidermal cysts Adenoma sebaceum Cutaneous neurofibromas/facial [readbag.com]

Isolated Congenital Breast Hypoplasia or Aplasia

The sex incidence is equal and there is no racial or ethnic predilection. 2 Most characteristic of tuberous sclerosis, are facial angiofibromas (adenoma sebaceum) which, while [basicmedicalkey.com]

Smooth, yellow or red fibrous plaques on the forehead may appear in infancy and be a presenting sign of tuberous sclerosis. 3, 8 Unilateral facial angiofibromas have been [basicmedicalkey.com]

[…] noted and could represent segmental expression. 9 Mutiple facial angiofibromas without any known genetic disorder have been described. 10 White macular lesions, which may [basicmedicalkey.com]

Pheochromocytoma-Islet Cell Tumor Syndrome

angiofibromas, subependymal nodules, cortical and subcortical tubers, seizures, development delay/intellectual disability, renal angiomyolipomas, cardiac rhabdomyomas Gene [utswmed.org]

The presence of facial angiofibromas and collagenomas may allow presymptomatic diagnosis of MEN1 in relatives of diagnosed patients. [1] Adrenal tumors occur in 20-40% of [emedicine.medscape.com]

Multiple facial angiofibromas and collagenomas in patients with multiple endocrine neoplasia type 1.Arch. Dermatol. 1997; 133: 853-857 Pack S et al. [cell.com]

Deafness-Small Bowel Diverticulosis-Neuropathy Syndrome

Approved renewal sirolimus facial angiofibromas, tuberous sclerosis Approved renewal sirolimus facial angiofibromas, tuberous sclerosis Approved renewal sirolimus facial angiofibromas [pharmac.govt.nz]

angiofibromas, tuberous sclerosis Approved renewal sirolimus facial angiofibromas, tuberous sclerosis Approved renewal sirolimus facial angiofibromas, tuberous sclerosis [pharmac.govt.nz]

Dyschromatosis Universalis Hereditaria Type 1

Facial angiofibromas or forehead plaque 2. Nontraumatic ungual or periungual fibromas 3. Hypomelanotic macules (>3) 4. Shagreen patch (connective tissue nevus) 5. [ijdvl.com]

Hirschsprung Disease - Nail Hypoplasia - Dysmorphism

Facial angiofibromas, forehead plaque, periungual fibroma, hypomelanotic macules, Shagreen patches, multiple retinal hamartomas, Giant cell astrocytomas, SENs, Cortical tumors [quizlet.com]