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39 Possible Causes for Facial Muscle Weakness and Progressive Atrophy, Flaccid Paralysis, Limb Weakness

  • Motor Neuron Disease

    Symptoms include pharyngeal muscle weakness (involved with swallowing), weak jaw and facial muscles, progressive loss of speech, and tongue muscle atrophy.[web.archive.org] Selective distal upper limb muscle weakness and atrophy with non-significant lower limb weakness during follow-up was the most frequent motor pattern, present in 18 patients[ncbi.nlm.nih.gov] Diagnostic pointers in limb-onset MND [ 1 ] Asymmetrical distal weakness frequently occurs. Brisk reflexes will occur in a wasted limb.[patient.info]

  • Adult Spinal Muscular Atrophy

    Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord.[patient.info] The examination may show all the characteristic findings of a lower motor neuron disease, namely absent/decreased reflexes, hypotonia, flaccid paralysis and muscle fasciculations[symptoma.com] As the disease progresses patients may notice limb weakness starting in the pelvis or shoulders, or weakness of the facial and tongue muscles.[cedars-sinai.edu]

  • Spinal Muscular Atrophy

    Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord.[patient.info] Flaccid paralysis Scoliosis Bed sores: Long term paraplegia may lead to pressure sores Respiratory failure Death Spinal muscular atrophy is transmitted via an autosomal-recessive[symptoma.com] As the disease progresses patients may notice limb weakness starting in the pelvis or shoulders, or weakness of the facial and tongue muscles.[cedars-sinai.edu]

  • Neuromuscular Junction Disorder

    Signs: there is ptosis, facial weakness, atrophy of the sternocieidomastoid muscles, cataracts, and decreased intelligence.[academic.sun.ac.za] Autonomic dysfunction (blurred vision, diplopia, bradycardia, and hypotension) followed by descending flaccid paralysis occur Wound botulism Results from contamination of[academic.oup.com] Diagnosis  Clinical Features:  Proximal Distal limb weakness  Initial presentation with difficulties to walk.[slideshare.net]

  • Autosomal Recessive Lower Motor Neuron Disease with Childhood Onset

    Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord.[patient.info] paralysis Dec tone Atrophy NB may look like Werdnig-Hoffmann Disease aka Spinal Muscular Atrophy type 1 Autosomal recessive Anterior horn degenerates Missing SurvivalMotorNeuron1[alancam.com] In family A the pathological findings and the clinical presentation with symmetrical proximal limb weakness show similarities with autosomal dominant SMA.[link.springer.com]

  • Upper Motor Neuron Disease

    Symptoms include pharyngeal muscle weakness (muscles that are involved in swallowing), weak facial muscles, progressive loss of speech, and tongue muscle atrophy.[advancedpsy.com] Seite 204 - AK (1993) Acute motor axonal neuropathy: A frequent cause of acute flaccid paralysis in China. Ann Neurol 33:333-342. ‎[books.google.de] weakness Advanced stage: Weakness in the muscles, in particular the limbs, where movement becomes more and more difficult The limb muscles begin to shrink and some develop[newhealthadvisor.com]

  • Amyotrophic Lateral Sclerosis

    In cranial nerves, common symptoms are atrophy of facial muscles and progressive bulbar palsy (PBP).[flexikon.doccheck.com] A characteristic finding is albuminocytological dissociation in the cerebrospinal fluid, and the clinical presentation is typically an ascending flaccid paralysis with loss[doi.org] We report the case of a 61-year-old man who presented with progressively worsening limb weakness and dysphagia.[ncbi.nlm.nih.gov]

  • Multifocal Motor Neuropathy

    In the first patient the symptoms were slowly progressive with bulbar muscle impairment, generalized weakness, muscular atrophy with cramps and fasciculations.[moh-it.pure.elsevier.com] Acute motor axonal neuropathy: a frequent cause of acute flaccid paralysis in China. Ann Neurol 1993 ; 33 : 333 –42. Brown WF, Feasby TE.[jnnp.bmj.com] The initial high-dose intravenous immunoglobulin treatment significantly improved left upper limb muscle weakness.[ncbi.nlm.nih.gov]

  • Lower Motor Neuron Syndrome with Late-Adult Onset

    Symptoms include pharyngeal muscle weakness (muscles that are involved in swallowing), weak facial muscles, progressive loss of speech, and tongue muscle atrophy.[advancedpsy.com] The infection leads to the development of acute flaccid paralysis, which can be bulbar or spinal in distribution.[clinicalgate.com] In family A the pathological findings and the clinical presentation with symmetrical proximal limb weakness show similarities with autosomal dominant SMA.[link.springer.com]

  • Facioscapulohumeral Muscular Dystrophy

    Flaccid dysarthria results from the facial muscle paralysis. A pair of siblings had FSH MD that was accompanied by the unusual finding of sensorineural hearing loss.[ncbi.nlm.nih.gov] FSHD presentation with foot drop or lower limb proximal weakness appeared to be more frequent than expected.[ncbi.nlm.nih.gov] Facioscapulohumeral muscular dystrophy is an autosomal-dominant, slowly progressive myopathy that involves facial, shoulder, and upper arm muscles.[ncbi.nlm.nih.gov]

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