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10 Possible Causes for Facial Muscle Weakness and Progressive Atrophy, Grip Strength Decreased

  • Amyotrophic Lateral Sclerosis

    Prior animal studies have shown that silencing SOD1 led to preservation of grip strength and a delay in the onset of motor function deficits [ 125, 126 ].[doi.org] In cranial nerves, common symptoms are atrophy of facial muscles and progressive bulbar palsy (PBP).[flexikon.doccheck.com] Symptoms include pharyngeal muscle weakness (involved with swallowing), weak jaw and facial muscles, progressive loss of speech, and tongue muscle atrophy.[web.archive.org]

  • Motor Neuron Disease

    Symptoms include pharyngeal muscle weakness (involved with swallowing), weak jaw and facial muscles, progressive loss of speech, and tongue muscle atrophy.[web.archive.org] Progressive bulbar palsy , also called progressive bulbar atrophy, involves the brain stem—the bulb-shaped region containing lower motor neurons needed for swallowing, speaking[ninds.nih.gov] Progressive bulbar palsy, also called progressive bulbar atrophy, involves the brain stem—the bulb-shaped region containing lower motor neurons needed for swallowing, speaking[web.archive.org]

  • Myotonic Dystrophy

    Clinical Presentation: Variable, progressive disability; facial and distal limb muscle weakness with myotonia; cataracts; cardiac conduction defects; diabetes mellitus; and[ajnr.org] The clinical course led progressively to major disability with severe proximal weakness and atrophy and, later on, distal weakness, atrophy and neck extensor weakness responsible[doi.org] , in males, testicular atrophy Key Diagnostic Features: MRI features: Subcortical hyperintensity of the white matter on T2-weighted sequences, with a predilection for the[ajnr.org]

  • Lambert Eaton Myasthenic Syndrome

    MuSK MG should be considered if there is facial or tongue weakness with atrophy, or weakness that predominates in neck or shoulder muscles.[docksci.com] MG follows a variable course, but usually progresses.[docksci.com]

  • Muscular Atrophy

    A hand-grip-strength test has been used to help diagnose sarcopenia in studies, and may be used in some clinics ( 18 ).[healthline.com] Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord.[patient.info] Decreased strength might show itself in other ways too, including walking more slowly, becoming exhausted more easily and having less interest in being active ( 17 ).[healthline.com]

  • Distal Myopathy Type 3

    The forearms may become mildly atrophic with decrease in grip strength; the small muscles of the hands are spared.[ncbi.nlm.nih.gov] The following features are however constantly present: atrophy of the intrinsic hand muscles, facial muscle involvement, myotonia and dystrophic changes in nonmuscular tissue[neuroweb.us] In adulthood, it presents with myotonia, progressive muscle weakness and wasting affecting first distal limbs muscles or ptosis and facial weakness.[neuroweb.us]

  • Neuromuscular Junction Disorder

    His grip is slightly weak at 4 . Strength doesn't decrease or increase with repeated trials.[mda.org] Signs: there is ptosis, facial weakness, atrophy of the sternocieidomastoid muscles, cataracts, and decreased intelligence.[academic.sun.ac.za] Patients present in adult life with particular symptoms: Myotonic: Difficulty with releasing grip Dystrophic: Weakness of the distal muscles of the arms and legs.[academic.sun.ac.za]

  • Inclusion Body Myositis

    By 14 months, there was a significant decrease in muscle force in mutant VCP mice ( P 0.0001; n 10), as assessed by longitudinal analysis of grip strength as well as acute[doi.org] […] disease of middle-aged , beginning in legs, causing atrophy and weakness of quadriceps, sparing facial and oropharyngeal muscles EMG Abnormal electrical 'irritation', slowing[medical-dictionary.thefreedictionary.com] […] myositis that is not autoimmune and does not respond to immunosuppressive therapy, a clinical diagnosis of exclusion, confirmed by typical histologic features Clinical Slowly progressive[medical-dictionary.thefreedictionary.com]

  • Fingerprint Body Myopathy

    His grip is slightly weak at 4 . Strength doesn't decrease or increase with repeated trials.[mda.org] Within few years the disease progressed to generalized muscle weakness and atrophy, ptosis, ophthalmoplegia externa and areflexia.[scipers.com] First symptoms in both patients appeared at 4 to 5 years of age with a ⠜sleepy facial expression⠝, clumsy gait and rapid fatigue.[scipers.com]

  • Miyoshi Myopathy Type 2

    The forearms may become mildly atrophic with decrease in grip strength. It is caused by mutations in the DYSF gene and is inherited in an autosomal recessive manner.[diseaseinfosearch.org] There is often asymmetric quadriceps, hamstring, biceps, brachioradialis, or calf weakness and atrophy. Muscle pain is common.[emedicine.medscape.com] Facial weakness, hand weakness, and contractures are uncommon. Progression is slow, and walking is retained. Cardiac and respiratory function is normal.[emedicine.medscape.com]

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