Create issue ticket

10 Possible Causes for Facial Muscle Weakness and Progressive Atrophy, Grip Strength Decreased, Limb Weakness

  • Motor Neuron Disease

    Symptoms include pharyngeal muscle weakness (involved with swallowing), weak jaw and facial muscles, progressive loss of speech, and tongue muscle atrophy.[] Selective distal upper limb muscle weakness and atrophy with non-significant lower limb weakness during follow-up was the most frequent motor pattern, present in 18 patients[] Diagnostic pointers in limb-onset MND [ 1 ] Asymmetrical distal weakness frequently occurs. Brisk reflexes will occur in a wasted limb.[]

  • Lambert Eaton Myasthenic Syndrome

    MuSK MG should be considered if there is facial or tongue weakness with atrophy, or weakness that predominates in neck or shoulder muscles.[] Here, we describe a patient with a 5-year history of cervical myelopathy who presented with recurrent limb weakness of her limbs and complained of recent progressive weakness[] Neurological examination revealed muscle weakness, predominantly in the proximal parts of the limbs.[]

  • Myotonic Dystrophy

    Clinical Presentation: Variable, progressive disability; facial and distal limb muscle weakness with myotonia; cataracts; cardiac conduction defects; diabetes mellitus; and[] Patient-reported perceived changes (worse/stable) in balance, walking, lower-limb weakness, stair-climbing and hand weakness were used as criteria.[] In the clinical neurological examination, there was a facial but no limb muscle weakness or atrophy. Ankle jerks were weak.[]

  • Amyotrophic Lateral Sclerosis

    Prior animal studies have shown that silencing SOD1 led to preservation of grip strength and a delay in the onset of motor function deficits [ 125, 126 ].[] In cranial nerves, common symptoms are atrophy of facial muscles and progressive bulbar palsy (PBP).[] We report the case of a 61-year-old man who presented with progressively worsening limb weakness and dysphagia.[]

  • Distal Myopathy Type 3

    The forearms may become mildly atrophic with decrease in grip strength; the small muscles of the hands are spared.[] The following features are however constantly present: atrophy of the intrinsic hand muscles, facial muscle involvement, myotonia and dystrophic changes in nonmuscular tissue[] Welander distal myopathy (WDM) is a late adult-onset autosomal dominant disorder, characterized by a slow progression and distal limb weakness of the extremity muscles.[]

  • Neuromuscular Junction Disorder

    His grip is slightly weak at 4 . Strength doesn't decrease or increase with repeated trials.[] Signs: there is ptosis, facial weakness, atrophy of the sternocieidomastoid muscles, cataracts, and decreased intelligence.[] Diagnosis  Clinical Features:  Proximal Distal limb weakness  Initial presentation with difficulties to walk.[]

  • Muscular Atrophy

    A hand-grip-strength test has been used to help diagnose sarcopenia in studies, and may be used in some clinics ( 18 ).[] Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord.[] His bilateral thigh muscle atrophy showed improvement and lower limb weakness was obviously alleviated and he could stand and walk with the help of others 4 weeks later.[]

  • Fingerprint Body Myopathy

    His grip is slightly weak at 4 . Strength doesn't decrease or increase with repeated trials.[] Within few years the disease progressed to generalized muscle weakness and atrophy, ptosis, ophthalmoplegia externa and areflexia.[] There was no limb extremity weakness, and the biopsy was obtained from a deltoid muscle ( Julien et al 1974 ).[]

  • Inclusion Body Myositis

    By 14 months, there was a significant decrease in muscle force in mutant VCP mice ( P 0.0001; n 10), as assessed by longitudinal analysis of grip strength as well as acute[] […] disease of middle-aged , beginning in legs, causing atrophy and weakness of quadriceps, sparing facial and oropharyngeal muscles EMG Abnormal electrical 'irritation', slowing[] Antibody-positive patients had a higher adjusted mortality risk (HR 1.89, 95% CI 1.11 to 3.21, p 0.019), lower frequency of proximal upper limb weakness at disease onset ([]

  • Miyoshi Myopathy Type 2

    The forearms may become mildly atrophic with decrease in grip strength. It is caused by mutations in the DYSF gene and is inherited in an autosomal recessive manner.[] There is often asymmetric quadriceps, hamstring, biceps, brachioradialis, or calf weakness and atrophy. Muscle pain is common.[] Most myopathies present with proximal, symmetric limb weakness (arms or legs) with preserved reflexes and sensation.[]

Similar symptoms