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10 Possible Causes for Facial Muscle Weakness and Progressive Atrophy, Grip Strength Decreased, Limb Weakness

  • Motor Neuron Disease

    Symptoms include pharyngeal muscle weakness (involved with swallowing), weak jaw and facial muscles, progressive loss of speech, and tongue muscle atrophy.[web.archive.org] Selective distal upper limb muscle weakness and atrophy with non-significant lower limb weakness during follow-up was the most frequent motor pattern, present in 18 patients[ncbi.nlm.nih.gov] Diagnostic pointers in limb-onset MND [ 1 ] Asymmetrical distal weakness frequently occurs. Brisk reflexes will occur in a wasted limb.[patient.info]

  • Lambert Eaton Myasthenic Syndrome

    MuSK MG should be considered if there is facial or tongue weakness with atrophy, or weakness that predominates in neck or shoulder muscles.[docksci.com] Here, we describe a patient with a 5-year history of cervical myelopathy who presented with recurrent limb weakness of her limbs and complained of recent progressive weakness[ncbi.nlm.nih.gov] Neurological examination revealed muscle weakness, predominantly in the proximal parts of the limbs.[ncbi.nlm.nih.gov]

  • Myotonic Dystrophy

    Clinical Presentation: Variable, progressive disability; facial and distal limb muscle weakness with myotonia; cataracts; cardiac conduction defects; diabetes mellitus; and[ajnr.org] Patient-reported perceived changes (worse/stable) in balance, walking, lower-limb weakness, stair-climbing and hand weakness were used as criteria.[ncbi.nlm.nih.gov] In the clinical neurological examination, there was a facial but no limb muscle weakness or atrophy. Ankle jerks were weak.[bmcresnotes.biomedcentral.com]

  • Amyotrophic Lateral Sclerosis

    Prior animal studies have shown that silencing SOD1 led to preservation of grip strength and a delay in the onset of motor function deficits [ 125, 126 ].[doi.org] In cranial nerves, common symptoms are atrophy of facial muscles and progressive bulbar palsy (PBP).[flexikon.doccheck.com] We report the case of a 61-year-old man who presented with progressively worsening limb weakness and dysphagia.[ncbi.nlm.nih.gov]

  • Distal Myopathy Type 3

    The forearms may become mildly atrophic with decrease in grip strength; the small muscles of the hands are spared.[ncbi.nlm.nih.gov] The following features are however constantly present: atrophy of the intrinsic hand muscles, facial muscle involvement, myotonia and dystrophic changes in nonmuscular tissue[neuroweb.us] Welander distal myopathy (WDM) is a late adult-onset autosomal dominant disorder, characterized by a slow progression and distal limb weakness of the extremity muscles.[dx.doi.org]

  • Neuromuscular Junction Disorder

    His grip is slightly weak at 4 . Strength doesn't decrease or increase with repeated trials.[mda.org] Signs: there is ptosis, facial weakness, atrophy of the sternocieidomastoid muscles, cataracts, and decreased intelligence.[academic.sun.ac.za] Diagnosis  Clinical Features:  Proximal Distal limb weakness  Initial presentation with difficulties to walk.[slideshare.net]

  • Muscular Atrophy

    A hand-grip-strength test has been used to help diagnose sarcopenia in studies, and may be used in some clinics ( 18 ).[healthline.com] Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord.[patient.info] His bilateral thigh muscle atrophy showed improvement and lower limb weakness was obviously alleviated and he could stand and walk with the help of others 4 weeks later.[ncbi.nlm.nih.gov]

  • Fingerprint Body Myopathy

    His grip is slightly weak at 4 . Strength doesn't decrease or increase with repeated trials.[mda.org] Within few years the disease progressed to generalized muscle weakness and atrophy, ptosis, ophthalmoplegia externa and areflexia.[scipers.com] There was no limb extremity weakness, and the biopsy was obtained from a deltoid muscle ( Julien et al 1974 ).[medlink.com]

  • Inclusion Body Myositis

    By 14 months, there was a significant decrease in muscle force in mutant VCP mice ( P 0.0001; n 10), as assessed by longitudinal analysis of grip strength as well as acute[doi.org] […] disease of middle-aged , beginning in legs, causing atrophy and weakness of quadriceps, sparing facial and oropharyngeal muscles EMG Abnormal electrical 'irritation', slowing[medical-dictionary.thefreedictionary.com] Antibody-positive patients had a higher adjusted mortality risk (HR 1.89, 95% CI 1.11 to 3.21, p 0.019), lower frequency of proximal upper limb weakness at disease onset ([ncbi.nlm.nih.gov]

  • Miyoshi Myopathy Type 2

    The forearms may become mildly atrophic with decrease in grip strength. It is caused by mutations in the DYSF gene and is inherited in an autosomal recessive manner.[diseaseinfosearch.org] There is often asymmetric quadriceps, hamstring, biceps, brachioradialis, or calf weakness and atrophy. Muscle pain is common.[emedicine.medscape.com] Most myopathies present with proximal, symmetric limb weakness (arms or legs) with preserved reflexes and sensation.[accessmedicine.mhmedical.com]

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