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10 Possible Causes for Facial Muscle Weakness and Progressive Atrophy, Grip Strength Decreased, Muscle Twitch

  • Amyotrophic Lateral Sclerosis

    Prior animal studies have shown that silencing SOD1 led to preservation of grip strength and a delay in the onset of motor function deficits [ 125, 126 ].[] In cranial nerves, common symptoms are atrophy of facial muscles and progressive bulbar palsy (PBP).[] twitching for 3 years.[]

  • Motor Neuron Disease

    Symptoms include pharyngeal muscle weakness (involved with swallowing), weak jaw and facial muscles, progressive loss of speech, and tongue muscle atrophy.[] A 69-year-old man with long-standing depression and failing memory presented with muscle twitches of 8 months' duration.[] […] wasting and weakness, absent reflexes, loss of weight and muscle twitching.[]

  • Myotonic Dystrophy

    Clinical Presentation: Variable, progressive disability; facial and distal limb muscle weakness with myotonia; cataracts; cardiac conduction defects; diabetes mellitus; and[] , fast twitch; also called SERCA1) leading to muscle wasting.[] The clinical course led progressively to major disability with severe proximal weakness and atrophy and, later on, distal weakness, atrophy and neck extensor weakness responsible[]

  • Lambert Eaton Myasthenic Syndrome

    MuSK MG should be considered if there is facial or tongue weakness with atrophy, or weakness that predominates in neck or shoulder muscles.[] They can sometimes cause side effects, such as stomach cramps, muscle twitching, diarrhoea and nausea.[] […] weakness, improves with repetitive effort More susceptible to both SCh and non-depolarizing NMBDs Titrate small doses of NMBDs to quantitative twitch monitoring Beware gastroparesis[]

  • Neuromuscular Junction Disorder

    His grip is slightly weak at 4 . Strength doesn't decrease or increase with repeated trials.[] Signs: there is ptosis, facial weakness, atrophy of the sternocieidomastoid muscles, cataracts, and decreased intelligence.[] The most common side effects from these agents are gastrointestinal disturbances (nausea, diarrhea) and muscle twitching.[]

  • Muscular Atrophy

    A hand-grip-strength test has been used to help diagnose sarcopenia in studies, and may be used in some clinics ( 18 ).[] Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord.[] Hypotonia or diminished muscle tone Involuntary contractions or twitching of muscles called fasciculations Respiratory problems Some children may need a wheelchair and develop[]

  • Fingerprint Body Myopathy

    His grip is slightly weak at 4 . Strength doesn't decrease or increase with repeated trials.[] Within few years the disease progressed to generalized muscle weakness and atrophy, ptosis, ophthalmoplegia externa and areflexia.[] ) Muscle atrophy (Medical Encyclopedia) Muscle function loss (Medical Encyclopedia) Muscle twitching (Medical Encyclopedia) Rhabdomyolysis (Medical Encyclopedia) Weakness[]

  • Distal Myopathy Type 3

    The forearms may become mildly atrophic with decrease in grip strength; the small muscles of the hands are spared.[] The following features are however constantly present: atrophy of the intrinsic hand muscles, facial muscle involvement, myotonia and dystrophic changes in nonmuscular tissue[] Based on histochemical reaction for myosin adenosine triphosphatase (ATPase) Type 1 muscle fibers: These are slow twitch, fatigue resistant, have slow oxidative metabolism[]

  • Inclusion Body Myositis

    By 14 months, there was a significant decrease in muscle force in mutant VCP mice ( P 0.0001; n 10), as assessed by longitudinal analysis of grip strength as well as acute[] […] disease of middle-aged , beginning in legs, causing atrophy and weakness of quadriceps, sparing facial and oropharyngeal muscles EMG Abnormal electrical 'irritation', slowing[] .: Transgenic expression of beta-APP in fast-twitch skeletal muscle leads to calcium dyshomeostasis and IBM-like pathology. FASEB J 2006, 20: 2165–2167.[]

  • Miyoshi Myopathy Type 2

    The forearms may become mildly atrophic with decrease in grip strength. It is caused by mutations in the DYSF gene and is inherited in an autosomal recessive manner.[] There is often asymmetric quadriceps, hamstring, biceps, brachioradialis, or calf weakness and atrophy. Muscle pain is common.[] Miyoshi Myopathy (MM) is a congenital distal myopathy caused by defective muscle membrane repair due to mutations in DYSFERLIN.[]

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