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10 Possible Causes for Facial Muscle Weakness and Progressive Atrophy, Grip Strength Decreased, Neck Weakness

  • Amyotrophic Lateral Sclerosis

    An 82-year-old woman developed neck weakness and dysarthria with antibodies against acetylcholine receptor (AChR) and low-density lipoprotein receptor-related protein 4 (LRP4[] Prior animal studies have shown that silencing SOD1 led to preservation of grip strength and a delay in the onset of motor function deficits [ 125, 126 ].[] In cranial nerves, common symptoms are atrophy of facial muscles and progressive bulbar palsy (PBP).[]

  • Lambert Eaton Myasthenic Syndrome

    Neurological examination revealed ptosis, dysarthria, neck weakness, hyporeflexia of all limbs, and autonomic failure.[] MuSK MG should be considered if there is facial or tongue weakness with atrophy, or weakness that predominates in neck or shoulder muscles.[] The main symptoms are weakness in the legs, arms, neck and face, as well as problems with automatic body functions, such as controlling blood pressure.[]

  • Myotonic Dystrophy

    […] that neck extension weakness is most pronounced in DM1.[] Clinical Presentation: Variable, progressive disability; facial and distal limb muscle weakness with myotonia; cataracts; cardiac conduction defects; diabetes mellitus; and[] Muscle weakness and atrophy: Muscle weakness affects the face and neck muscles but is much less severe than in DM1.[]

  • Motor Neuron Disease

    ALS, PLS, PMA, MMA) Symmetric weakness without sensory loss (e.g. PMA, PLS) Symmetric focal midline proximal weakness (neck, trunk, bulbar involvement; e.g.[] Symptoms include pharyngeal muscle weakness (involved with swallowing), weak jaw and facial muscles, progressive loss of speech, and tongue muscle atrophy.[] Motor symptoms may include: Muscle weakness A progressive inability to move the arms, legs, face, tongue or neck.[]

  • Distal Myopathy Type 3

    They include: drooping muscles in your face, producing a thin, haggard look difficulty lifting your neck due to weak neck muscles difficulty swallowing droopy eyelids, or[] The forearms may become mildly atrophic with decrease in grip strength; the small muscles of the hands are spared.[] The following features are however constantly present: atrophy of the intrinsic hand muscles, facial muscle involvement, myotonia and dystrophic changes in nonmuscular tissue[]

  • Fingerprint Body Myopathy

    His grip is slightly weak at 4 . Strength doesn't decrease or increase with repeated trials.[] In Eur J Pediatr, Feb 2016 UNASSIGNED: Mutations in SEPN1 cause selenoprotein N (SEPN)-related myopathy (SEPN-RM) characterized by early-onset axial and neck weakness, spinal[] Within few years the disease progressed to generalized muscle weakness and atrophy, ptosis, ophthalmoplegia externa and areflexia.[]

  • Neuromuscular Junction Disorder

    The neck extensors are often weak, and the head droops.[] His grip is slightly weak at 4 . Strength doesn't decrease or increase with repeated trials.[] Signs: there is ptosis, facial weakness, atrophy of the sternocieidomastoid muscles, cataracts, and decreased intelligence.[]

  • Muscular Atrophy

    A hand-grip-strength test has been used to help diagnose sarcopenia in studies, and may be used in some clinics ( 18 ).[] Non-invasive ventilation at night can prevent apnea in sleep, and some individuals may also require assisted ventilation due to muscle weakness in the neck, throat, and chest[] Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord.[]

  • Inclusion Body Myositis

    In rare cases, muscle weakness in the neck can cause the head to drop.[] By 14 months, there was a significant decrease in muscle force in mutant VCP mice ( P 0.0001; n 10), as assessed by longitudinal analysis of grip strength as well as acute[] […] disease of middle-aged , beginning in legs, causing atrophy and weakness of quadriceps, sparing facial and oropharyngeal muscles EMG Abnormal electrical 'irritation', slowing[]

  • Miyoshi Myopathy Type 2

    The forearms may become mildly atrophic with decrease in grip strength. It is caused by mutations in the DYSF gene and is inherited in an autosomal recessive manner.[] Slow progression to finger extension weakness and neck flexor weakness is the rule, whereas late generalized muscle weakness and severe disability are unusual.[] There is often asymmetric quadriceps, hamstring, biceps, brachioradialis, or calf weakness and atrophy. Muscle pain is common.[]

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