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10 Possible Causes for Facial Muscle Weakness and Progressive Atrophy, Grip Strength Decreased, Neck Weakness

  • Amyotrophic Lateral Sclerosis

    An 82-year-old woman developed neck weakness and dysarthria with antibodies against acetylcholine receptor (AChR) and low-density lipoprotein receptor-related protein 4 (LRP4[ncbi.nlm.nih.gov] Prior animal studies have shown that silencing SOD1 led to preservation of grip strength and a delay in the onset of motor function deficits [ 125, 126 ].[doi.org] In cranial nerves, common symptoms are atrophy of facial muscles and progressive bulbar palsy (PBP).[flexikon.doccheck.com]

  • Lambert Eaton Myasthenic Syndrome

    Neurological examination revealed ptosis, dysarthria, neck weakness, hyporeflexia of all limbs, and autonomic failure.[ncbi.nlm.nih.gov] MuSK MG should be considered if there is facial or tongue weakness with atrophy, or weakness that predominates in neck or shoulder muscles.[docksci.com] The main symptoms are weakness in the legs, arms, neck and face, as well as problems with automatic body functions, such as controlling blood pressure.[nhs.uk]

  • Myotonic Dystrophy

    […] that neck extension weakness is most pronounced in DM1.[ncbi.nlm.nih.gov] Clinical Presentation: Variable, progressive disability; facial and distal limb muscle weakness with myotonia; cataracts; cardiac conduction defects; diabetes mellitus; and[ajnr.org] Muscle weakness and atrophy: Muscle weakness affects the face and neck muscles but is much less severe than in DM1.[dystrophiemyotonique.chuq.qc.ca]

  • Motor Neuron Disease

    ALS, PLS, PMA, MMA) Symmetric weakness without sensory loss (e.g. PMA, PLS) Symmetric focal midline proximal weakness (neck, trunk, bulbar involvement; e.g.[en.wikipedia.org] Symptoms include pharyngeal muscle weakness (involved with swallowing), weak jaw and facial muscles, progressive loss of speech, and tongue muscle atrophy.[web.archive.org] Motor symptoms may include: Muscle weakness A progressive inability to move the arms, legs, face, tongue or neck.[theaftd.org]

  • Distal Myopathy Type 3

    They include: drooping muscles in your face, producing a thin, haggard look difficulty lifting your neck due to weak neck muscles difficulty swallowing droopy eyelids, or[healthline.com] The forearms may become mildly atrophic with decrease in grip strength; the small muscles of the hands are spared.[ncbi.nlm.nih.gov] The following features are however constantly present: atrophy of the intrinsic hand muscles, facial muscle involvement, myotonia and dystrophic changes in nonmuscular tissue[neuroweb.us]

  • Fingerprint Body Myopathy

    His grip is slightly weak at 4 . Strength doesn't decrease or increase with repeated trials.[mda.org] In Eur J Pediatr, Feb 2016 UNASSIGNED: Mutations in SEPN1 cause selenoprotein N (SEPN)-related myopathy (SEPN-RM) characterized by early-onset axial and neck weakness, spinal[gopubmed.org] Within few years the disease progressed to generalized muscle weakness and atrophy, ptosis, ophthalmoplegia externa and areflexia.[scipers.com]

  • Neuromuscular Junction Disorder

    The neck extensors are often weak, and the head droops.[what-when-how.com] His grip is slightly weak at 4 . Strength doesn't decrease or increase with repeated trials.[mda.org] Signs: there is ptosis, facial weakness, atrophy of the sternocieidomastoid muscles, cataracts, and decreased intelligence.[academic.sun.ac.za]

  • Muscular Atrophy

    A hand-grip-strength test has been used to help diagnose sarcopenia in studies, and may be used in some clinics ( 18 ).[healthline.com] Non-invasive ventilation at night can prevent apnea in sleep, and some individuals may also require assisted ventilation due to muscle weakness in the neck, throat, and chest[ninds.nih.gov] Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord.[patient.info]

  • Inclusion Body Myositis

    In rare cases, muscle weakness in the neck can cause the head to drop.[rarediseases.org] By 14 months, there was a significant decrease in muscle force in mutant VCP mice ( P 0.0001; n 10), as assessed by longitudinal analysis of grip strength as well as acute[doi.org] […] disease of middle-aged , beginning in legs, causing atrophy and weakness of quadriceps, sparing facial and oropharyngeal muscles EMG Abnormal electrical 'irritation', slowing[medical-dictionary.thefreedictionary.com]

  • Miyoshi Myopathy Type 2

    The forearms may become mildly atrophic with decrease in grip strength. It is caused by mutations in the DYSF gene and is inherited in an autosomal recessive manner.[diseaseinfosearch.org] Slow progression to finger extension weakness and neck flexor weakness is the rule, whereas late generalized muscle weakness and severe disability are unusual.[neupsykey.com] There is often asymmetric quadriceps, hamstring, biceps, brachioradialis, or calf weakness and atrophy. Muscle pain is common.[emedicine.medscape.com]

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