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10 Possible Causes for Facial Muscle Weakness and Progressive Atrophy, Grip Strength Decreased, Weight Loss

  • Amyotrophic Lateral Sclerosis

    loss in the early stages.[] Prior animal studies have shown that silencing SOD1 led to preservation of grip strength and a delay in the onset of motor function deficits [ 125, 126 ].[] In cranial nerves, common symptoms are atrophy of facial muscles and progressive bulbar palsy (PBP).[]

  • Lambert Eaton Myasthenic Syndrome

    RESULTS: Age at onset, smoking behavior, weight loss, Karnofsky performance status, bulbar involvement, male sexual impotence, and the presence of Sry-like high-mobility group[] MuSK MG should be considered if there is facial or tongue weakness with atrophy, or weakness that predominates in neck or shoulder muscles.[] More than 50 years of age at onset of symptoms, positive history for smoking, weight loss, bulbar symptoms, male sexual impotence and Karnofsky performance status lower than[]

  • Motor Neuron Disease

    We describe a 52-year-old man with body weight loss and bulbar palsy, who exhibited muscle atrophy and weakness with fasciculation especially in the respiratory muscles 4[] Symptoms include pharyngeal muscle weakness (involved with swallowing), weak jaw and facial muscles, progressive loss of speech, and tongue muscle atrophy.[] loss, and reduced survival.[]

  • Myotonic Dystrophy

    Dysphagia is one of the most problematic symptoms of DM1 because it may cause weight loss, aspiration pneumonias or sudden death.[] Clinical Presentation: Variable, progressive disability; facial and distal limb muscle weakness with myotonia; cataracts; cardiac conduction defects; diabetes mellitus; and[] The clinical course led progressively to major disability with severe proximal weakness and atrophy and, later on, distal weakness, atrophy and neck extensor weakness responsible[]

  • Distal Myopathy Type 3

    loss Sweating Tremor Neck swelling Decreased TSH Non specific Myotonic Hypothyroidism [8] 55 Proximal Rhabdomyolysis Signs of hypothyroidism H/o weight gain Myxoedema Muscle[] The forearms may become mildly atrophic with decrease in grip strength; the small muscles of the hands are spared.[] The following features are however constantly present: atrophy of the intrinsic hand muscles, facial muscle involvement, myotonia and dystrophic changes in nonmuscular tissue[]

  • Inclusion Body Myositis

    The most common symptoms were muscle weakness, falls, dysphagia, and weight loss. Hypertension was the main comorbidity.[] By 14 months, there was a significant decrease in muscle force in mutant VCP mice ( P 0.0001; n 10), as assessed by longitudinal analysis of grip strength as well as acute[] […] disease of middle-aged , beginning in legs, causing atrophy and weakness of quadriceps, sparing facial and oropharyngeal muscles EMG Abnormal electrical 'irritation', slowing[]

  • Muscular Atrophy

    Summary: Noticeable loss of strength or stamina and unintentional weight loss are signs of multiple diseases, including sarcopenia.[] Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord.[] A hand-grip-strength test has been used to help diagnose sarcopenia in studies, and may be used in some clinics ( 18 ).[]

  • Neuromuscular Junction Disorder

    The patient may describe tightness in the throat, and may complain of pooling of secretions as well as develop insidious weight loss.[] His grip is slightly weak at 4 . Strength doesn't decrease or increase with repeated trials.[] Signs: there is ptosis, facial weakness, atrophy of the sternocieidomastoid muscles, cataracts, and decreased intelligence.[]

  • Fingerprint Body Myopathy

    Cytoplasmic body neuromyopathy presenting as respiratory failure and weight loss. J Neurol Sci 1979;41:1-9. 5. Edstrom L, Thronell LE, Eriksson A.[] His grip is slightly weak at 4 . Strength doesn't decrease or increase with repeated trials.[] Within few years the disease progressed to generalized muscle weakness and atrophy, ptosis, ophthalmoplegia externa and areflexia.[]

  • Miyoshi Myopathy Type 2

    Loss and Lung Nodules 411 Case 65 A Woman with Difficulty Walking and Ataxia 415 Case 66 A Man with Progressive Neuropathy and Congestive Heart Failure 422 Case 67 An Elderly[] The forearms may become mildly atrophic with decrease in grip strength. It is caused by mutations in the DYSF gene and is inherited in an autosomal recessive manner.[] There is often asymmetric quadriceps, hamstring, biceps, brachioradialis, or calf weakness and atrophy. Muscle pain is common.[]

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