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26 Possible Causes for Facial Muscle Weakness and Progressive Atrophy, Hypersomnia, Limb Weakness

  • Muscular Dystrophy

    Abstract Facioscapulohumeral muscular dystrophy is an autosomal-dominant, slowly progressive myopathy that involves facial, shoulder, and upper arm muscles.[ncbi.nlm.nih.gov] Apathy and hypersomnia are common features of myotonic dystrophy.[ncbi.nlm.nih.gov] The symptoms of FSH dystrophy may appear during childhood with severe facial and limb weakness or develop slowly and gradually in adulthood with progressive difficulty closing[kennedykrieger.org]

  • Motor Neuron Disease

    Symptoms include pharyngeal muscle weakness (involved with swallowing), weak jaw and facial muscles, progressive loss of speech, and tongue muscle atrophy.[web.archive.org] Selective distal upper limb muscle weakness and atrophy with non-significant lower limb weakness during follow-up was the most frequent motor pattern, present in 18 patients[ncbi.nlm.nih.gov] Diagnostic pointers in limb-onset MND [ 1 ] Asymmetrical distal weakness frequently occurs. Brisk reflexes will occur in a wasted limb.[patient.info]

  • Myotonic Dystrophy

    Clinical Presentation: Variable, progressive disability; facial and distal limb muscle weakness with myotonia; cataracts; cardiac conduction defects; diabetes mellitus; and[ajnr.org] In the later stages of the disease, some people experience sleep apnea and hypersomnia. Women with myotonic dystrophy have an increased risk for pregnancy complications.[en.wikibooks.org] Patient-reported perceived changes (worse/stable) in balance, walking, lower-limb weakness, stair-climbing and hand weakness were used as criteria.[ncbi.nlm.nih.gov]

  • Spinal Muscular Atrophy Type 3

    Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord.[patient.info] […] fugax, Transient global amnesia ) Cerebrovascular disease ( MCA, ACA, PCA, Foville's, Millard-Gubler, Lateral medullary, Weber's, Lacunar stroke ) Sleep disorders Insomnia - Hypersomnia[wikidoc.org] weakness that resembled muscular dystrophy, but the muscle biopsy and EMG indicated neuronal disease.[jkna.org]

  • Young Adult-Onset Distal Hereditary Motor Neuropathy

    weakness DHMN8 600175 TRPV4 12q24.11 Autosomal dominant Congenital distal spinal muscular atrophy Affects primarily distal muscles of lower limbs, non-progressive, rare DHMNJ[en.wikipedia.org] Lower limb and upper limb weakness is common, beginning towards the hands and feet and sometimes extending above the elbows and knees.[cmtausa.org] Mild hypersomnia with prolonged sleep time (704 min) and ultradian sleep–wake rhythm with sleep occurrence every 11.8 5.3 h were documented.[frontiersin.org]

  • Distal Hereditary Motor Neuropathy

    facial weakness and muscle atrophy in the hands ( 2 – 4 ).[spandidos-publications.com] […] fugax Transient global amnesia Acute aphasia Stroke MCA ACA PCA Foville's Millard–Gubler Lateral medullary Medial medullary Weber's Lacunar stroke Sleep disorders Insomnia Hypersomnia[en.wikipedia.org] Results : 45 years-old male patient presented progressive gait disorder, with lower limb weakness, associated to bradykinesia, followed by gait ataxia and falls since age[deepdyve.com]

  • Lower Motor Neuron Syndrome with Late-Adult Onset

    Symptoms include pharyngeal muscle weakness (muscles that are involved in swallowing), weak facial muscles, progressive loss of speech, and tongue muscle atrophy.[advancedpsy.com] Increased sleepiness, or hypersomnia, may be the cause of drowsiness or narcolepsy. Narcolepsy may be described as an intrusion of REM sleep into the waking hours.[britannica.com] In family A the pathological findings and the clinical presentation with symmetrical proximal limb weakness show similarities with autosomal dominant SMA.[link.springer.com]

  • Distal Hereditary Motor Neuropathy Type 1

    weakness DHMN8 600175 TRPV4 12q24.11 Autosomal dominant Congenital distal spinal muscular atrophy Affects primarily distal muscles of lower limbs, non-progressive, rare DHMNJ[en.wikipedia.org] They developed mild symmetrical distal lower limb weakness, muscle wasting, and severe foot… CONTINUE READING[semanticscholar.org] […] muscular weakness and atrophy, without sensory impairment.[orpha.net]

  • Autosomal Dominant Progressive External Ophthalmoplegia Type 6

    PEO6 DNA2 AD PEO w/variable, slowly progressive features; onset: childhood-adulthood Slender build Facial muscle weakness; exertional dyspnea; obstructive sleep apnea; myopathy[ncbi.nlm.nih.gov] An 11-year-old boy with Kearns-Sayre syndrome developed hypersomnia associated with bithalamic lesions and had complete absence of sleep spindles on a nocturnal polysomnogram[wikigenes.org] Exercise intolerance, limb weakness, hearing loss, and diabetes may also precede the occurrence of the stroke-like episodes.[umdf.org]

  • Polyglucosan Body Myopathy Type 2

    The following features are however constantly present: atrophy of the intrinsic hand muscles, facial muscle involvement, myotonia and dystrophic changes in nonmuscular tissue[neuroweb.us] Foundation – Idiopathic Hypersomnia The Jansen’s Foundation – Jansen Type Metaphyseal Chondrodysplasia The LAMFoundation – Lymphangioleiomyomatosis (LAM) The Life Raft Group[globalgenes.org] Skeletal muscle atrophy Limb-girdle muscle weakness Slow progression Variable expressivity ...[familydiagnosis.com]

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