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10 Possible Causes for Facial Redness, Plethora, Proximal Muscle Weakness of the Lower Extremity

  • Cushing's Disease

    […] severe physical and physiological changes in the body, including uncontrollable weight gain, central obesity (abdomen that sticks out with thin arms and legs), a round, red[novartis.com] The clinical signs suggesting Cushing's disease, such as obesity, moon face, hirsutism, and facial plethora are already present on presentation.[ncbi.nlm.nih.gov] RESULTS: Hirsutism, plethora facial, muscular weakness and muscular atrophy were more frequent in the MIC patients.[ncbi.nlm.nih.gov]

  • Iatrogenic Cushing's Disease

    The most common symptoms and signs of excess levels of cortisol in the body are obesity, facial plethora (facial redness), violaceous abdominal striae (purple or bluish stripes[britannica.com] Obvious moon face (Figure 2 a), facial plethora, acne, oral mucositis, increased truncal and abdominal fat, buffalo hump, proximal myopathy and hirsutism were noted at the[mrmjournal.biomedcentral.com] Any sign or symptom of cortisol excess can develop initially, but muscle weakness, bruising, hypertension, facial rounding and plethora eventually occur.[aafp.org]

  • Adrenocortical Carcinoma

    Cushing's syndrome (see this term) occurs in a third of cases with the most common signs being a moon-like facies, centripetal fat distribution and plethora.[orpha.net] Virilization was the most common clinical sign (37 of 40); other signs included abdominal mass, deepened voice, plethora, hypertension, seizures (seven patients) and, rarely[ascopubs.org]

  • ACTH-Secreting Pituitary Adenoma

    […] erythema Blushed cheeks Blushing Red face Red in the face [ more ] 0001041 Glucose intolerance 0001952 Hirsutism Excessive hairiness 0001007 Increased circulating ACTH level[rarediseases.info.nih.gov] […] face (moon face), above the collar bone (supraclavicular) and on back of neck (buffalo hump) Skin changes with easy bruising, purplish stretch marks (stria) and red cheeks (plethora[pituitary.org] Skin changes may include easy bruising, with purplish stretch marks (stria) and red cheeks (plethora) as well as excess hair growth (hirsutism) on the face and body.[pacificneuroscienceinstitute.org]

  • Botulism

    Paralysis The wound may or may not appear red and swollen.[mayoclinic.org] There is currently a plethora of drug leads and therapies against numerous diseases, ranging from small molecule compounds to nucleic acids to peptides to proteins with varying[ncbi.nlm.nih.gov] By history, the most common symptoms were dysphagia (66%), proximal muscle weakness of upper and lower extremity (60%), neck flexor muscle weakness (33%), ophthalmoplegia[ncbi.nlm.nih.gov]

  • Carcinomatous Myopathic Syndrome

    facial flush/oedema, salivation, lachrymation, and potentially tachycardia, fever, anxiety, tremor, hypotension, and left-sided cardiac lesions.[jtd.amegroups.com] Thus, the differential diagnosis of IIM includes the many disorders associated with muscle complaints and is considerably challenging, not only because of the plethora of[musculoskeletalkey.com] […] endocrine activity secrete histamine and 5-hydroxytryptophan (lacking the decarboxylase to convert it into 5-hydroxytryptamine) to the systemic circulation, causing episodes of red[jtd.amegroups.com]

  • ACTH-Independent Cushing Syndrome

    The main clinical features (Fig. 2) and their frequency are: 95% weight gain around the central regions (centripetal obesity) 90% facial plethora (red face) 90% change of[endocrinesurgery.net.au] Facial obesity manifested as "moon" face Buffalo hump or dorsocervical fat pad Enlarged fat pads in the supraclavicular fossa Truncal obesity Generalized obesity Facial plethora[specialty.mims.com] : muscle weakness is more often proximal and is usually most prominent in the lower extremities (myopathy) BONE : significant osteopenia and osteoporosis fractures, typically[slidepptx.com]

  • Amish Nemaline Myopathy

    The hallmark symptoms are generalized muscle weakness with facial involvement or predominant involvement of proximal limb and respiratory muscles.[genome.jp] Physical Examination Laboratory Findings Creatine Kinase Muscle Biopsy Electromyogram Endocrine Cushing's disease [4] 25 45 Proximal Decreased libido Obesity / weight gain Plethora[wikidoc.org] The lower extremities were most often initially affected by limb weakness and distribution of muscle weakness was remarkably in proximal parts.[synapse.koreamed.org]

  • Reducing Body Myopathy

    In this subtype, death during the neonatal period has been described. [26] However, a milder subtype has also been described with marked facial weakness but retained ambulation[emedicine.medscape.com] Nevertheless, fatigue, exercise intolerance and myalgias can also occur in a plethora of non-myopathic conditions.[news-medical.net] It typically presents with distal upper extremity weakness accompanied by proximal lower extremity muscle weakness.[patient.info]

  • Miyoshi Muscular Dystrophy Type 3

    […] action potential to repetitive nerve stimulation Type 2 muscle fiber atrophy Fatigable weakness Impaired vibratory sensation Decreased motor nerve conduction velocity Ragged-red[mendelian.co] Physical Examination Laboratory Findings Creatine Kinase Muscle Biopsy Electromyogram Endocrine Cushing's disease [4] 25 45 Proximal Decreased libido Obesity / weight gain Plethora[wikidoc.org] Two (16%) patients had proximal–distal phenotype with muscle weakness equally affecting both proximal and distal regions of the lower extremities.[frontiersin.org]

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