Factor-v-leiden-mutation: Causes & Reasons

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Possible Causes for factor v leiden mutation

Cerebral Thrombosis

AIM: To investigate whether the factor V Leiden mutation (FVL), the prothrombin gene G20210A variant or the methylenetetrahydrofolate reductase (MTHFR) C677T genotype are [ncbi.nlm.nih.gov]

Thrombophilia testing demonstrated heterozygosity for the factor V Leiden mutation. [circ.ahajournals.org]

TABLE 1: Risk Factors for Cerebral Venous Thrombosis Thrombophilia Deficiencies of antithrombin, protein C, and protein S Factor V Leiden mutation Prothrombin gene mutation [webmedcentral.com]

Thrombosis

Herein is presented a case of heterozygous Factor V Leiden (FVL) and hyperhomocysteinemia with homozygous methylenetetrahydrofolate reductase (MTHFR) mutations that caused [ncbi.nlm.nih.gov]

V Leiden mutations. [ncbi.nlm.nih.gov]

Superficial thrombophlebitis is often observed in individuals who are heterozygous or homozygous for the factor V Leiden mutation. [ihtc.org]

Superior Mesenteric Vein Thrombosis

A 74-year-old white woman, with a heterozygous Factor V Leiden mutation and no underlying liver disease or portal hypertension, presented over the course of 13 months for [ncbi.nlm.nih.gov]

VIII levels, factor V 'Leiden' gene mutation, and paroxysmal nocturnal hematuria screen. [ncbi.nlm.nih.gov]

A complete coagulation profile, including thrombin time, platelet count, protein C, protein S, antithrombin III, homocysteine level, factor V Leiden mutation, plasminogen, [ncbi.nlm.nih.gov]

Deep Vein Thrombosis

Hematologic workup also discovered a factor V Leiden mutation, further predisposing the patient to DVT. [ncbi.nlm.nih.gov]

V Leiden mutation. [ncbi.nlm.nih.gov]

Factor V Leiden Mutation in Iraqi Patients with Deep Venous Thrombosis. [iasj.net]

Mesenteric Vein Thrombosis

Factor V Leiden mutation is a risk factor for the development of thromboembolic events in pregnancy. [ncbi.nlm.nih.gov]

We report a typical case of familial and recidivant deep vein thrombosis in a young man heterozygous for the factor V Leiden mutation (Arg506-Gln), who developed an acute [ncbi.nlm.nih.gov]

In this paper, we described a pregnant patient with mesenteric vein thrombosis who was heterozygous for the factor V Leiden mutation. [ncbi.nlm.nih.gov]

Venous Thrombosis

Factor V Leiden Mutation in Iraqi Patients with Deep Venous Thrombosis. [iasj.net]

Abstract Congenital causes of venous thrombosis have gained increasing prominence with the description of the factor V Leiden mutation and the prothrombin gene mutation. [annals.org]

Results: Factor V Leiden mutation was documented in 8 patients (16%), compared to 1 control (2.5%) (Odds Ratio 7.4; p 0.0397). [iasj.net]

Coagulation Abnormalities

We determined levels of protein C, protein S, factor VIII, and fibrinogen and tested for the factor V Leiden and prothrombin G20210A mutations. [ncbi.nlm.nih.gov]

The prevalence of factor V Leiden mutation and G20210A prothrombin gene variant was similar in the MM patients and in the control group. [haematologica.org]

[…] dysfibrinogenemia Heterozygous Factor V Leiden mutation High molecular weight kininogen deficiency Homozygous Factor V Leiden mutation Ineffective thrombopoiesis Placental [icd9data.com]

Fitzsimmons-McLachlan-Gilbert Syndrome

II deficiency Factor V deficiency Factor V Leiden mutation Factor VII deficiency Factor VIII deficiency Factor X deficiency, congenital Factor X deficiency Factor XI deficiency [bioreference.net]

Facio thoraco genital syndrome Faciocardiomelic dysplasia lethal Faciocardiorenal syndrome Faciooculoacousticorenal syndrome Facioscapulohumeral muscular dystrophy Fact Factor [academickids.com]

[…] type Facio thoraco genital syndrome Faciocardiomelic dysplasia lethal Faciocardiorenal syndrome Faciooculoacousticorenal syndrome Facioscapulohumeral muscular dystrophy Factor [bioreference.net]

Intracranial Sinus Thrombosis

The patient was heterozygous for factor V Leiden mutation. [ncbi.nlm.nih.gov]

V Leiden mutation Cancer Collagen vascular diseases such as lupus, granulomatosis with polyangiitis, and Behcet syndrome Obesity Low blood pressure in the brain (intracranial [elcaminohospital.org]

V Leiden mutation Cancer Collagen vascular diseases like lupus, Wegener’s granulomatosis, and Behcet syndrome Obesity Low blood pressure in the brain (intracranial hypotension [hopkinsmedicine.org]

Cerebral Venous Sinus Disorder

V Leiden mutation Cancer Collagen vascular diseases like lupus, granulomatosis with polyangiitis, and Behcet syndrome Obesity Low blood pressure in the brain (intracranial [hopkinsmedicine.org]

Results of tests for factor V Leiden mutation, prothrombin gene mutation, and antiphospholipid antibodies were negative. [consultant360.com]

Effects of second and third generation oral contraceptives and their respective progestagens on the coagulation system in the absence or presence of the factor V Leiden mutation [ijrcog.org]

Protein S Deficiency

The patient also had factor V Leiden mutation and persistently elevated anticardiolipin antibodies. [ncbi.nlm.nih.gov]

In addition, he was diagnosed to have protein S deficiency with Factor V Leiden mutation. [ncbi.nlm.nih.gov]

The patient was found to be heterozygous for the factor V Leiden mutation and had a functional protein S deficiency. [ncbi.nlm.nih.gov]

Recurrent Thrombophlebitis due to Hereditary Disorders

Factor V Leiden and Factor V deficiency “Pseudohomozygous” Factor V Leiden occurs in individuals who are doubly heterozygous for Factor V Leiden and a Factor V null mutation [nature.com]

V Leiden mutation.” [natural-fertility-info.com]

Inherited blood abnormalities Factor V variant (V Leiden) APC resistance, Molecular genetics - genetic disorders - Factor V Leiden mutation. [rcpa.edu.au]

Cerebral Vein Thrombosis

Odds ratios for CVT were found to be 3.38 for factor V Leiden mutation, 9.27 for Prothrombin G20210A mutation, 32 for antiphospholipid syndrome and 4.07 for hyperhomocysteinemia [ncbi.nlm.nih.gov]

A transition G A at position 20210 is associated with elevated prothrombim concentration, mutation in this gene and presence of factor V Leiden mutation may increase 5-10 [casereports.in]

Factor II Mutation

Risk factors Patients screened for factor V Leiden and factor II G20210A mutations (n 40) Patients carriers of factor V Leiden or factor II G20210A mutation (n 6) Age(mean [omicsonline.org]

V Leiden Mutation and PT 20210 Mutation Tests? [dovemed.com]

Profile or Test Panel DNA/Factor V Leiden DNA/Factor II Prothrombin Mutation Also Known as (Alias) Factor II genotyping Method polymerase chain reaction (PCR) based Test Information [bloodworksnw.org]

Factor V Deficiency

Factor V (Five) Leiden Mutation What is Factor V Leiden Mutation? Factor V Leiden is a common change in a gene that controls a protein called Factor V. [melbournehaematology.com.au]

From Tiffany Whittle : Is there a difference between f actor V Leiden mutation and factor V deficiency ? [fritsmafactor.com]

Overall, 5% of the world population harbors the factor V Leiden mutation. [themedicalbiochemistrypage.org]

Thrombomodulin-Related Bleeding Disorder

V Leiden mutation was found in 14%. [47] However, in another study of 50 patients with RMS, it was concluded that factor V Leiden, prothrombin G20210A mutation, and 5,10- [emedicine.medscape.com]

Factor V Leiden mutation causes factor V deficiency or parahemophilia, which is a rare bleeding disorder. [clotbase.bicnirrh.res.in]

Inherited causes of thrombosis Factor V Leiden Prothrombin 202010 Mutation Hyperhomocysteinemia Elevated Clotting Factor Levels Antithrombin Protein C Deficiency Skin Necrosis [ihtc.org]

Protein C Deficiency

The factor V Leiden mutation causing activated PC (APC) resistance is an additional risk factor for VT. [ncbi.nlm.nih.gov]

Detailed investigations revealed reduced (20%) functional assay of protein C suggestive of the diagnosis of severe Type II protein C deficiency with Factor V Leiden mutation [ncbi.nlm.nih.gov]

5 Leiden mutation Factor 5 Leiden mutation, heterozygous Factor 5 Leiden mutation, homozygous Factor V Leiden mutation Factor V Leiden mutation, heterozygous Factor V Leiden [icd9data.com]

Lateral Sinus Thrombosis

Three underwent anticoagulation for 6 months (1 had heterozygous factor V Leiden mutation). All survived; deafness occurred in 5 patients (4 transient, 1 persistent). [ncbi.nlm.nih.gov]

Laboratory data demonstrated an elevated D-dimer and homozygosity for the factor V Leiden mutation. [ncbi.nlm.nih.gov]

All the five children were found to be heterozygote for the C677T MTHFR mutation and a child presented also heterozygosity for factor V Leiden mutation. [ncbi.nlm.nih.gov]

Hughes-Stovin Syndrome

A thrombophilic state was assumed because of a factor V Leiden mutation. [circ.ahajournals.org]

Portal Vein Thrombosis

Factor V Leiden mutation was present in 2% of cases and is uncommon in India. [news-medical.net]

In one of them the cause was idiopathic and the other two resulted from thrombophilia (protein S deficiency and Factor V Leiden mutation). [fn.bmj.com]

Thrombophilia due to Activated-Protein C Resistance

If the APC resistance test is abnormal, DNA-based testing for the factor V Leiden mutation (F5DNA / Factor V Leiden [R506Q] Mutation, Blood) may be helpful in confirming or [mayomedicallaboratories.com]

Investigations revealed that he had an underlying Activated protein C resistance due to factor V Leiden mutation. [mayoclinic.pure.elsevier.com]

(March 2015) Factor V Leiden Mutation in Women with Early Recurrent Pregnancy Loss: A Meta-Analysis and Systematic Review of the Causal Association. [labtestsonline.org]

Arterial Thrombosis

Factor V Leiden mutation is a contributing risk factor in cases of small bowel infarction. [ncbi.nlm.nih.gov]

[…] the factor V gene referred to as Factor V Leiden. [ncbi.nlm.nih.gov]

We postulate that screening for factors such as factor V Leiden and MTHFR C677T mutation may be beneficial to patients associated with thromboembolism and idiopathic nephrotic [ncbi.nlm.nih.gov]

Hereditary Protein C Deficiency

5 Leiden mutation, factor 5 Leiden mutation heterozygous, factor 5 Leiden mutation homozygous, factor V Leiden mutation, factor V Leiden mutation heterozygous, factor V Leiden [healthresearchfunding.org]

Factor V Leiden mutation is the most common cause of the syndrome, accounting for 40-50% of cases. [ispub.com]

Placental Infarction

OBJECTIVES: The factor V Leiden mutation is the most common genetic predisposition to thrombosis. [ncbi.nlm.nih.gov]

The rate of positive maternal tests for antiphospholipid syndrome, factor V Leiden, and prothrombin gene mutation were compared with the rate of detection of one or more gross [ncbi.nlm.nih.gov]

Dizon-Townson, DS, Meline, L, Nelson, LM, Varner, M, Ward, K 1997 Fetal carriers of the factor V Leiden mutation are prone to miscarriage and placental infarction Am J Obstet [link.springer.com]

May-Thurner Syndrome

V Leiden mutation on exogenous hormone therapy, with subsequent spontaneous rupture of the LCIV leading to fatal hemoperitoneum. [ncbi.nlm.nih.gov]

Antiphospholipid antibodies (antiphosphatidylserine, anticardiolipin, and antiphosphatidyl-ethanolamine), factor V Leiden mutation by polymerase chain reaction, and homocyst [ncbi.nlm.nih.gov]

[…] or estrogen therapy, pregnancy, extended periods of sitting or certain inherited disorders which increase the risk of abnormal clotting such as Factor V Leiden mutation, [vascularcarecentre.com]

Facial Dysmorphism-Immunodeficiency-Livedo-Short Stature Syndrome

"Livedoid vasculopathy and its association with factor V Leiden mutation" (PDF). Singapore Med J. 53 (12): e258–60. PMID 23268168. [infogalactic.com]

"Livedoid vasculopathy and its association with factor V Leiden mutation". Singapore Med J. 53 (12): e258–60. PMID 23268168?. [wikidoc.org]

V Leiden mutation [20] FILS syndrome (polymerase ε1 mutation in a human syndrome with facial dysmorphism, immunodeficiency, livedo, and short stature) [21] Primary hyperoxaluria [ipfs.io]

Hereditary Factor I Deficiency

V Leiden mutation D68.52 Prothrombin gene mutation D68.59 Other primary thrombophilia Inclusion term(s): Antithrombin III deficiency Hypercoagulable state NOS Primary hypercoagulable [icd10coded.com]

[…] the factor V Leiden mutation. [medtextfree.wordpress.com]

Budd-Chiari Syndrome

Activated protein C resistance caused by the factor V Leiden mutation may be responsible for primary BCS. [ncbi.nlm.nih.gov]

He was evaluated for hypercoagulability and was found to be heterozygous for Factor V Leiden mutation and his protein C level was 38% of normal. [ncbi.nlm.nih.gov]

V Leiden mutation and antiphospholipid antibody syndrome, similar to her mother. [ncbi.nlm.nih.gov]

Hereditary Coagulopathy

Factor V Leiden Thrombophilia Cerebrovascular disorders in children with the factor V Leiden mutation Jan. 2002 Frequency of factor V Leiden in juvenile migraine with aura [pediatricstroke.org]

Renal Vein Thrombosis

Whereas major risk factors in adults are the procoagulant states such as protein C or S deficiency, factor V Leiden mutation, primary or secondary antiphospholipid syndrome [ncbi.nlm.nih.gov]

The postnatal thrombophilia investigations revealed a heterozygous factor V Leiden mutation. [ncbi.nlm.nih.gov]

RVT is an uncommon but definite problem in neonates. [6, 7] A possible association exists between RVT and the factor V Leiden mutation in this age group. [emedicine.com]