Factor V Leiden Mutation: Causes & Reasons

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Possible Causes for Factor V Leiden Mutation

Thrombosis

V Leiden mutations. [ncbi.nlm.nih.gov]

Superficial thrombophlebitis is often observed in individuals who are heterozygous or homozygous for the factor V Leiden mutation. [ihtc.org]

V Leiden Discovery by Björn Dalhbäck of a mutation in the gene for coagulation factor V that promotes thrombosis. [stago-us.com]

Cerebral Thrombosis

AIM: To investigate whether the factor V Leiden mutation (FVL), the prothrombin gene G20210A variant or the methylenetetrahydrofolate reductase (MTHFR) C677T genotype are [ncbi.nlm.nih.gov]

Thrombophilia testing demonstrated heterozygosity for the factor V Leiden mutation. [circ.ahajournals.org]

TABLE 1: Risk Factors for Cerebral Venous Thrombosis Thrombophilia Deficiencies of antithrombin, protein C, and protein S Factor V Leiden mutation Prothrombin gene mutation [webmedcentral.com]

Deep Vein Thrombosis

V Leiden mutation. [ncbi.nlm.nih.gov]

Hematologic workup also discovered a factor V Leiden mutation, further predisposing the patient to DVT. [ncbi.nlm.nih.gov]

The direct test for factor V Leiden mutation is positive for the heterozygous type. [doi.org]

Superior Mesenteric Vein Thrombosis

VIII levels, factor V 'Leiden' gene mutation, and paroxysmal nocturnal hematuria screen. [ncbi.nlm.nih.gov]

A complete coagulation profile, including thrombin time, platelet count, protein C, protein S, antithrombin III, homocysteine level, factor V Leiden mutation, plasminogen, [ncbi.nlm.nih.gov]

A 74-year-old white woman, with a heterozygous Factor V Leiden mutation and no underlying liver disease or portal hypertension, presented over the course of 13 months for [ncbi.nlm.nih.gov]

Mesenteric Vein Thrombosis

Factor V Leiden mutation is a risk factor for the development of thromboembolic events in pregnancy. [ncbi.nlm.nih.gov]

We report a typical case of familial and recidivant deep vein thrombosis in a young man heterozygous for the factor V Leiden mutation (Arg506-Gln), who developed an acute [ncbi.nlm.nih.gov]

V gene mutation (Factor V Leiden), G20210A prothrombin gene mutation, hyperhomocysteinemia, a part of which is associated with C677T methylene-tetrahydrofolate reductase [ispub.com]

Thrombomodulin-Related Bleeding Disorder

V Leiden mutation was found in 14%. [47] However, in another study of 50 patients with RMS, it was concluded that factor V Leiden, prothrombin G20210A mutation, and 5,10- [emedicine.medscape.com]

Inherited causes of thrombosis Factor V Leiden Prothrombin 202010 Mutation Hyperhomocysteinemia Elevated Clotting Factor Levels Antithrombin Protein C Deficiency Skin Necrosis [ihtc.org]

Factor V Leiden mutation causes factor V deficiency or parahemophilia, which is a rare bleeding disorder. [clotbase.bicnirrh.res.in]

Coagulation Abnormalities

We determined levels of protein C, protein S, factor VIII, and fibrinogen and tested for the factor V Leiden and prothrombin G20210A mutations. [ncbi.nlm.nih.gov]

[…] dysfibrinogenemia Heterozygous Factor V Leiden mutation High molecular weight kininogen deficiency Homozygous Factor V Leiden mutation Ineffective thrombopoiesis Placental [icd9data.com]

The prevalence of factor V Leiden mutation and G20210A prothrombin gene variant was similar in the MM patients and in the control group. [haematologica.org]

Venous Thrombosis

Congenital causes of venous thrombosis have gained increasing prominence with the description of the factor V Leiden mutation and the prothrombin gene mutation. [ncbi.nlm.nih.gov]

Abstract Congenital causes of venous thrombosis have gained increasing prominence with the description of the factor V Leiden mutation and the prothrombin gene mutation. [doi.org]

More recently, the description of the association between increased levels of coagulation factors and venous thrombosis and the finding that patients with thrombophilia can [ncbi.nlm.nih.gov]

Fitzsimmons-McLachlan-Gilbert Syndrome

II deficiency Factor V deficiency Factor V Leiden mutation Factor VII deficiency Factor VIII deficiency Factor X deficiency, congenital Factor X deficiency Factor XI deficiency [bioreference.net]

II deficiency * Factor V deficiency * Factor V Leiden mutation * Factor VII deficiency * Factor VIII deficiency * Factor X deficiency, congenital * Factor X deficiency * [en.academic.ru]

[…] type Facio thoraco genital syndrome Faciocardiomelic dysplasia lethal Faciocardiorenal syndrome Faciooculoacousticorenal syndrome Facioscapulohumeral muscular dystrophy Factor [bioreference.net]

Intracranial Sinus Thrombosis

The patient was heterozygous for factor V Leiden mutation. [ncbi.nlm.nih.gov]

such as heterozygous factor V Leiden or prothrombin G20210A mutation and high plasma levels of factor VIII. [ean.org]

[…] after factor V Leiden mutation. [nature.com]

Pelvic Vein Thrombophlebitis

Her medical history included a remote deep-vein thrombosis of the leg and heterozygosity for the factor V Leiden mutation. [nejm.org]

Superficial thrombophlebitis is observed in people who are homozygous or heterozygous for Factor V Leiden mutation. [varicosevascular.com]

Risk of venous thromboembolism and myocardial infarction associated with factor V Leiden and prothrombin mutations and blood type. CMAJ 2013; 185(5):E229–237. [vestnik.szd.si]

Hughes-Stovin Syndrome

A thrombophilic state was assumed because of a factor V Leiden mutation. [circ.ahajournals.org]

Portal Vein Thrombosis

Factor V Leiden mutation was present in 2% of cases and is uncommon in India. [news-medical.net]

In one of them the cause was idiopathic and the other two resulted from thrombophilia (protein S deficiency and Factor V Leiden mutation). [fn.bmj.com]

Recurrent Thrombophlebitis due to Hereditary Disorders

Factor V Leiden and Factor V deficiency “Pseudohomozygous” Factor V Leiden occurs in individuals who are doubly heterozygous for Factor V Leiden and a Factor V null mutation [nature.com]

V Leiden mutation.” [natural-fertility-info.com]

Inherited blood abnormalities Factor V variant (V Leiden) APC resistance, Molecular genetics - genetic disorders - Factor V Leiden mutation. [rcpa.edu.au]

Cerebral Venous Sinus Disorder

Results of tests for factor V Leiden mutation, prothrombin gene mutation, and antiphospholipid antibodies were negative. [consultant360.com]

V Leiden mutation Cancer Collagen vascular diseases like lupus, granulomatosis with polyangiitis, and Behcet syndrome Obesity Low blood pressure in the brain (intracranial [hopkinsmedicine.org]

Effects of second and third generation oral contraceptives and their respective progestagens on the coagulation system in the absence or presence of the factor V Leiden mutation [ijrcog.org]

Protein S Deficiency

5 Leiden mutation Factor 5 Leiden mutation, heterozygous Factor 5 Leiden mutation, homozygous Factor V Leiden mutation Factor V Leiden mutation, heterozygous Factor V Leiden [icd9data.com]

The patient was found to be heterozygous for the factor V Leiden mutation and had a functional protein S deficiency. [ncbi.nlm.nih.gov]

The patient also had factor V Leiden mutation and persistently elevated anticardiolipin antibodies. [ncbi.nlm.nih.gov]

Lateral Sinus Thrombosis

Three underwent anticoagulation for 6 months (1 had heterozygous factor V Leiden mutation). All survived; deafness occurred in 5 patients (4 transient, 1 persistent). [ncbi.nlm.nih.gov]

Laboratory data demonstrated an elevated D-dimer and homozygosity for the factor V Leiden mutation. [ncbi.nlm.nih.gov]

All the five children were found to be heterozygote for the C677T MTHFR mutation and a child presented also heterozygosity for factor V Leiden mutation. [ncbi.nlm.nih.gov]

Hereditary Coagulopathy

Factor V Leiden Thrombophilia Cerebrovascular disorders in children with the factor V Leiden mutation Jan. 2002 Frequency of factor V Leiden in juvenile migraine with aura [pediatricstroke.org]

Sagittal Sinus Thrombosis

The patient was found to be heterozygous for the factor V Leiden mutation and had a functional protein S deficiency. [ncbi.nlm.nih.gov]

V Leiden mutation Cancer Collagen vascular diseases like lupus, Wegener’s granulomatosis, and Behcet syndrome Obesity Low blood pressure in the brain (intracranial hypotension [hopkinsmedicine.org]

[…] after factor V Leiden mutation. [nature.com]

Cerebral Vein Thrombosis

Odds ratios for CVT were found to be 3.38 for factor V Leiden mutation, 9.27 for Prothrombin G20210A mutation, 32 for antiphospholipid syndrome and 4.07 for hyperhomocysteinemia [ncbi.nlm.nih.gov]

A transition G A at position 20210 is associated with elevated prothrombim concentration, mutation in this gene and presence of factor V Leiden mutation may increase 5-10 [casereports.in]

Prothrombin G20210A and factor V Leiden mutation as well as deficiencies in protein C, protein S or antithrombin III shall be mentioned as examples for hereditary diseases [symptoma.com]

Protein C Deficiency

The factor V Leiden mutation causing activated PC (APC) resistance is an additional risk factor for VT. [ncbi.nlm.nih.gov]

Laboratory findings including antinuclear factor, antiphospholipid antibodies and VDRL titer were normal. Factor V Leiden mutation was not detected. [dx.doi.org]

Factor V Deficiency

Although factor V Leiden thrombophilia increases the risk of blood clots, only about 10 percent of individuals with the factor V Leiden mutation ever develop abnormal clots [ghr.nlm.nih.gov]

Factor V (Five) Leiden Mutation What is Factor V Leiden Mutation? Factor V Leiden is a common change in a gene that controls a protein called Factor V. [melbournehaematology.com.au]

This mutation is known as Factor V Leiden (FVL) [i]. [medical-dictionary.thefreedictionary.com]

Factor II Mutation

Profile or Test Panel DNA/Factor V Leiden DNA/Factor II Prothrombin Mutation Also Known as (Alias) Factor II genotyping Method polymerase chain reaction (PCR) based Test Information [bloodworksnw.org]

Risk factors Patients screened for factor V Leiden and factor II G20210A mutations (n=40) Patients carriers of factor V Leiden or factor II G20210A mutation (n=6) Age(mean [omicsonline.org]

[…] with heterozygous factor V Leiden mutation (10.1%). [tmj.ro]

Hereditary Protein C Deficiency

5 Leiden mutation, factor 5 Leiden mutation heterozygous, factor 5 Leiden mutation homozygous, factor V Leiden mutation, factor V Leiden mutation heterozygous, factor V Leiden [healthresearchfunding.org]

Factor V Leiden mutation is the most common cause of the syndrome, accounting for 40-50% of cases. [ispub.com]

Hereditary Antithrombin Deficiency

V leiden mutation and 2.0% for homocystenemia. [jpma.org.pk]

The most common inherited thrombotic disorders include activated protein C resistance (factor V Leiden), prothrombin G20210A mutation, hyperhomocysteinemia, deficiencies of [tuberktoraks.org]

If you inherited the factor V Leiden mutation from one parent, your risk of having DVT goes up sevenfold; with both parents, it goes up 80-fold. [everydayhealth.com]

Hereditary Factor I Deficiency

[…] the factor V Leiden mutation. [medtextfree.wordpress.com]

Results of these tests were positive for the Factor V Leiden gene mutation. [reviewofoptometry.com]

Budd-Chiari Syndrome

He was evaluated for hypercoagulability and was found to be heterozygous for Factor V Leiden mutation and his protein C level was 38% of normal. [ncbi.nlm.nih.gov]

V Leiden mutation and antiphospholipid antibody syndrome, similar to her mother. [ncbi.nlm.nih.gov]

Activated protein C resistance caused by the factor V Leiden mutation may be responsible for primary BCS. [ncbi.nlm.nih.gov]

Abdominal Aortic Thrombosis

In our patient, the risk factors of smoking, hypercholesterolemia, and factor V Leiden mutation were present. [medscape.com]

Prevalence of the factor V Leiden mutation in children and neonates with thromboembolic disease. J Paediatr.1998:133:777-81. 5. Hughes GRV. [indianpediatrics.net]

The role of genetic factors, such as the factor V Leiden, antithrombin, protein C or protein S deficiency, the 20210A prothrombin mutation are recognized as common risk factors [nature.com]

Thrombophilia due to Activated-Protein C Resistance

If the APC resistance test is abnormal, DNA-based testing for the factor V Leiden mutation (F5DNA / Factor V Leiden [R506Q] Mutation, Blood) may be helpful in confirming or [mayomedicallaboratories.com]

Investigations revealed that he had an underlying Activated protein C resistance due to factor V Leiden mutation. [mayoclinic.pure.elsevier.com]

Antithrombin Deficiency

In the event of resistance to activated protein C, screening for factor V Leiden mutation is necessary. [stago-us.com]

If you inherited the factor V Leiden mutation from one parent, your risk of having DVT goes up sevenfold; with both parents, it goes up 80-fold. [everydayhealth.com]

Inherited causes of thrombosis Factor V Leiden Prothrombin 202010 Mutation Hyperhomocysteinemia Elevated Clotting Factor Levels Antithrombin Protein C Deficiency Skin Necrosis [ihtc.org]