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152 Possible Causes for Factor V Leiden Mutation, Leg Pain, Leg Swelling

  • Vein Disorder

    Most patients suffer from varicose veins, leg pain and swelling, restless legs, numerous painful superficial veins, and some suffer from very painful vein stasis ulcers.[] Swelling of the leg is a further sign that damaged or diseased vein valves are not functioning properly.[] If left untreated, it can lead to leg pain, swelling, ulcers, and other health problems.[]

  • Thrombosis

    This condition is characterized by pooling of blood, chronic leg swelling, increased pressure, increased pigmentation or discoloration of the skin, and leg ulcers known as[] leg swells and becomes chronically painful.[] Herein is presented a case of heterozygous Factor V Leiden (FVL) and hyperhomocysteinemia with homozygous methylenetetrahydrofolate reductase (MTHFR) mutations that caused[]

  • Deep Vein Thrombosis

    CASE REPORT: A previously healthy 6-month-old male was brought to the emergency department by his family with a chief complaint of left leg swelling.[] We report a case of a patient presenting with acute leg pain resembling that of a deep vein thrombosis, and a beginning leg compartment syndrome following a suspected ruptured[] Hematologic workup also discovered a factor V Leiden mutation, further predisposing the patient to DVT.[]

  • Lipedema

    In each group, the results were dismal as leg swelling worsened or was unchanged in greater than 90% whereas symptoms such as heaviness, fatigue, cramps (termed varicogenic[] *Pain in legs and sensitivity to touch caused by lymph blockage that leads to hardening of tissues.[] Additional past history found in Table 1 ), polycystic ovarian syndrome or gluten allergy (6.3 0.2% each), costochondritis or narcolepsy (4.2 0.2% each), or a factor V Leiden[]

  • May-Thurner Syndrome

    But providers should always rule out May-Thurner in a woman with unilateral swelling – typically in the left leg.[] This may result in painful swelling, similar to what was experienced by our patient, and discoloration of the legs.[] V Leiden mutation on exogenous hormone therapy, with subsequent spontaneous rupture of the LCIV leading to fatal hemoperitoneum.[]

  • Hemophilia

    […] weakness or clumsiness of the arms or legs or problems walking Double vision Convulsions or seizures[] “Pseudo homozygous” activated protein C resistance due to double heterozygous factor V defects (factor V Leiden mutation and type I quantitative factor V defect) associated[] Painful bleeding into the soft tissues of the arms and legs can lead to nerve damage.[]

  • Hemophilia A

    Painful bleeding into the soft tissues of the arms and legs can lead to nerve damage.[] Although the efficacy of Factor V Leiden was at issue, when it was applied in FII G20210A mutation, the thrombosis formation tendency increased [ 15 ].[] These types of bleeding can lead to throwing up blood or passing blood in the stool, stroke, and sudden severe pain in the joints or limbs.[]

  • Superficial Phlebitis

    Common Symptoms Include: Leg pain or tenderness Leg swelling Discoloration of leg; usually blue, purple, or red Regardless of the cause, Deep Vein Thrombosis (DVT) can be[] V Leiden mutation In women, hormone replacement therapy or birth control pills What are the signs and symptoms of STP?[] Some DVTs are without symptoms, while others are associated with the acute development of leg swelling, pain and tiredness.[]

  • Venous Insufficiency of Leg

    Leg pain at night is also a common phenomenon.[] Individuals who have underlying coagulation or blood clot disorders like factor V Leiden mutation or factor VIII are much more susceptible to develop leg ulcers from chronic[] Others experience restless leg syndrome, aching, or swelling.[]

  • Hemophilia B

    A minority of patients have coexisting thrombophilic states such as factor V Leiden mutation, protein C or protein S deficiency, or prothrombin G20210A mutations, which counterbalance[] Pathophysiology Factor IX deficiency, dysfunctional factor IX, or factor IX inhibitors lead to disruption of the normal intrinsic coagulation cascade, resulting in spontaneous[]

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