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177 Possible Causes for Factor V Leiden Mutation, Petechiae, Purpura

  • Purpura Fulminans

    Medscape: Purpura Fulminans[] The Factor V Leiden mutation ( FV L ) is associated with thrombotic events, and we hypothesized that children carrying FV L who develop meningococcal disease may be at increased[] The patient's condition aggravated, with need for invasive mechanical ventilation and intermittent haemodialysis, and evolution from a petechiae-like rash to purpura and gangrene[]

  • Bleeding Diathesis

    […] is a report of a case of a diffuse bleeding tendency in a pregnant woman who presented for emergency splenectomy with a tentative diagnosis of thrombotic thrombocytopenic purpura[] We tested for the presence of the Factor V Leiden mutation by PCR-amplifying a fragment of the factor V gene which contains the mutation site and then digesting the product[] An accurate description of the several forms of cutaneous bleeding (petechiae, purpuric spots, ecchymosis, haematomas, etc.) is needed for referrals and for controls.[]

  • Neonatal Purpura Fulminans

    Neonatal purpura fulminans is rare and may be inherited or acquired. It may ultimately lead to multiorgan failure and death.[] (factor V Leiden) mutation.[] In our case, cutaneous examination revealed multiple petechiae and ecchymotic patches with necrotic lesions and eschar formation.[]

  • Glanzmann Thrombasthenia

    […] recessive coagulopathy characterized by either qualitative or quantitative abnormalities of the membrane glycoprotein αIIbβ3 complex leading to bleeding tendencies, ranging from purpura[] In addition, heterozygous factor V Leiden G1691A and heterozygous MTHFR C677T gene mutations were detected.[] The clinical history of Glanzmann thrombasthenia may include the following: Excessive bleeding after dental extraction (this may often be the first sign of the disease) Petechiae[]

  • Hematologic Disease

    LS is a superior treatment for patients with idiopathic thrombocytopenic purpura and patients with small spleens.[] Examples include Factor V Leiden mutations, Protein C deficiency, and Lupus anticoagulant.[] The average platelet count in patients with petechiae was 48,000/mm 3 (range, 40,000-74,000/mm 3 ).[]

  • Chronic Kidney Insufficiency

    […] with renal failure may present as gastrointestinal bleeding, bleeding from cannulation sites, retinal haemorrhage, subdural haematoma, epistaxis, haematuria, ecchymosis, purpura[] […] lack in antithrombin, protein C, protein S, factor V Leiden mutation, as well as polymorphisms in the TGF-β1 gene, NO synthase, PAI-1, angiotensin-converting enzyme, methylene[] […] haemorrhage Subdural haematoma Epistaxis Haematuria Ecchymosis Purpura Bleeding from the gums Gingival bleeding Genital bleeding Haemoptysis Telangiectasia Haemarthrosis Petechiae[]

  • Cutaneous Leukocytoclastic Vasculitis

    Patients with hyperglobulinemic purpura, which may be a subset of leukocytoclastic vasculitis, should be examined for associated conditions.[] Protein C and protein S levels were normal and the factor V leiden mutation test was negative.[] A 71-year-old man presented with a high fever, polyarthralgia, petechiae and palpable purpura accompanied by livedoid change on his legs and feet.[]

  • Disseminated Intravascular Coagulation

    Acute perturbations in the hemostatic balance of anticoagulation and procoagulation antecede the manifestation of purpura fulminans, a rare syndrome of intravascular thrombosis[] Effect of the factor V Leiden mutation on the incidence and outcome of severe infection and sepsis. Neth. J. Med. 70, 306–310 (2012). 176. Hermans, P.[] Two weeks later, he was transferred to the West China Hospital with nasal hemorrhage for 1 week, hematochezia, hematuria, and petechiae for 5 days.[]

  • Essential Thrombocythemia

    […] hypergammaglobulinemic purpura ( D89.0 ) cryoglobulinemic purpura ( D89.1 ) essential (hemorrhagic) thrombocythemia ( D47.3 ) hemorrhagic thrombocythemia ( D47.3 ) purpura[] Factor V Leiden mutation carriership and venous thromboembolism in polycythemia vera and essential thrombocythemia. Am J Hematol. 2002 Sep. 71(1):1-6. [Medline].[] Petechiae are never seen.[]

  • Coagulation Abnormalities

    […] and other hemorrhagic conditions D69.0 Allergic purpura D69.1 Qualitative platelet defects D69.2 Other nonthrombocytopenic purpura D69.3 Immune thrombocytopenic purpura D69.4[] We determined levels of protein C, protein S, factor VIII, and fibrinogen and tested for the factor V Leiden and prothrombin G20210A mutations.[] INCREASED VASCULAR FRAGILITY seldom serious skin bruises, dependent petechiae, gum bleeding, hematuria, nosebleeds, GI bleeds.[]

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