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11 Possible Causes for Failure to Thrive, Focal Motor Seizure, Nodular Heterotopia of the Grey Matter

  • Parietal Lobe Tumor

    Focal motor or sensory deficits, including gait disturbance Suspicious headache Signs of elevated ICP (eg, papilledema) Generally, CT is the imaging modality of choice for[emedicine.medscape.com] Heterotopia present as nodular foci of grey matter intensity on all sequences. They do not enhance. Heterotopia Images of a typical subependymal heterotopia.[radiologyassistant.nl] Infants with brainstem tumors may also initially present with failure to thrive.[ncbi.nlm.nih.gov]

  • Lissencephaly

    After the first months of life, most children have mixed seizure disorders including persisting infantile spasms, focal motor and generalized tonic seizures [ Guerrini 2005[ncbi.nlm.nih.gov] Periventricular nodular heterotopia is characterized by aggregates of grey matter adjacent to the lateral ventricle and is mainly linked to mutations in the Filamin A (FLNA[ncbi.nlm.nih.gov] Symptoms of the disorder may include unusual facial appearance, difficulty swallowing, failure to thrive, muscle spasms, seizures, and severe psychomotor retardation.[ninds.nih.gov]

  • Infantile Choroidocerebral Calcification Syndrome

    Focal white matter lesions Lower limb asymmetry Abnormal myelination Nevus flammeus Severe global developmental delay Slow progression Ventriculomegaly Abnormality of the[mendelian.co] Usually nodular heterotopia at ventricular junction.[radnotes.co.nz] […] to thrive Sensorineural hearing impairment SOURCES: MONDO SCTID ORPHANET MESH GARD OMIM More info about RENAL TUBULAR ACIDOSIS, DISTAL, WITH PROGRESSIVE NERVE DEAFNESS Low[mendelian.co]

  • Edinburgh Malformation Syndrome

    Seizure types include atypical absences (62%), atonic and tonic drop attacks (73%), generalized tonic-clonic (35%), and focal seizures (26%).[karger.com] Symptoms - Edinburgh malformation syndrome * Facial abnormalities * Fluid buildup inside skull * Mental retardation * Retarded motor development * Failure to thrive * Infant[checkorphan.org] Periventricular Nodular Heterotopia PNH consists of nodules of grey matter located along the lateral ventricles with a total failure of migration of some neurons [Barkovich[karger.com]

  • Occipital Lobe Tumor

    Focal motor or sensory deficits, including gait disturbance Suspicious headache Signs of elevated ICP (eg, papilledema) Generally, CT is the imaging modality of choice for[emedicine.medscape.com] Heterotopia present as nodular foci of grey matter intensity on all sequences. They do not enhance. Heterotopia Images of a typical subependymal heterotopia.[radiologyassistant.nl] Hypothalamic: "diencephalic syndrome" (failure to thrive and emaciation in a happy and hungry child).[hawaii.edu]

  • Neuronal Migration Defect

    After the first months of life, most children have mixed seizure disorders including persisting infantile spasms, focal motor and generalized tonic seizures [ Guerrini 2005[ncbi.nlm.nih.gov] , whereas the DCX mutant brains showed more nodular heterotopia and irregular disruptions of the grey matter-white matter junction.[doi.org] Symptoms of the disorder may include unusual facial appearance, difficulty swallowing, failure to thrive, muscle spasms, seizures, and severe psychomotor retardation.[ninds.nih.gov]

  • Pachygyria-Mental Retardation-Seizures

    The children also had focal motor seizures, and their mild progressive hemi- plegia was almost certainly related to the epileptic attivity.[docslide.com.br] Heterotopia present as nodular foci of grey matter intensity on all sequences. They do not enhance. Heterotopia Images of a typical subependymal heterotopia.[radiologyassistant.nl] Other symptoms may include: difficulty feeding failure to thrive intellectual impairment malformed fingers, toes, or hands muscle spasms psychomotor impairment seizures trouble[healthline.com]

  • Bilateral Temporo-Occipital Polymicrogyria

    Focal motor seizures occurred in all cases and 25 had secondary generalised seizures. Six patients also had complex focal seizures.[paperity.org] Heterotopia present as nodular foci of grey matter intensity on all sequences. They do not enhance. Heterotopia Images of a typical subependymal heterotopia.[radiologyassistant.nl] […] to thrive Abnormality of the middle ear Muscular hypotonia Nystagmus Partial agenesis of the corpus callosum Cryptorchidism Nevus Perisylvian polymicrogyria Leukemia Small[mendelian.co]

  • Complex Cortical Dysplasia with other Brain Malformations Type 4

    Seizure types include atypical absences (62%), atonic and tonic drop attacks (73%), generalized tonic-clonic (35%), and focal seizures (26%).[karger.com] Nodular heterotopias of grey matter are found in association with other migration disorders and may be the cause of partial seizures.[jnnp.bmj.com] Children in this group present with severe ID, spastic quadriparesis, gastroesophageal reflux, and poor feeding, leading to failure to thrive.[neupsykey.com]

  • Complex Cortical Dysplasia with other Brain Malformations Type 3

    Seizure types include atypical absences (62%), atonic and tonic drop attacks (73%), generalized tonic-clonic (35%), and focal seizures (26%).[karger.com] Nodular heterotopias of grey matter are found in association with other migration disorders and may be the cause of partial seizures.[jnnp.bmj.com] […] to grow and thrive, difficulties with feeding, swelling in the extremities, and a smaller than normal head.[en.wikipedia.org]

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