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36 Possible Causes for Failure to Thrive, Hyperbilirubinemia, Onset in First Weeks or Months of Life

  • Cholestasis

    Clinical description The first cholestatic episode can occur at any age but onset within the first two decades of life is most common.[orpha.net] Failure to Thrive One of the major clinical effects of cholestasis, particularly chronic cholestasis, is failure to thrive.[emedicine.medscape.com] We believe our patient’s persistent direct hyperbilirubinemia with biopsy-confirmed cholestasis was also likely related to his AHC.[pediatrics.aappublications.org]

  • Wolman Disease

    This particular form of these disorders is early in onset, usually developing within the first weeks or month of life.[disability-benefits-help.org] In infants, poor weight gain, massive hepatosplenomegaly, calcified adrenal glands (present about 2/3 of the time), vomiting, diarrhea and failure to thrive are indicative[ncbi.nlm.nih.gov] Significant hyperbilirubinemia (peak total and direct bilirubin levels: 54.4 and 45.8 mg/dl, respectively) developed at 7 weeks from BMT.[nature.com]

  • 3Beta-Hydroxy-Delta5-C27-Steroid Oxidoreductase Deficiency

    The first cholestatic episode can occur at any age but onset within the first two decades of life is most common.[findzebra.com] Affected infants show failure to thrive and secondary coagulopathy.[malacards.org] The condition accounts for 1% to 2% of all occurrences of conjugated hyperbilirubinemia during infancy.[symptoma.com]

  • Laryngeal Stridor

    Congenital abnormalities of the upper airway typically present in the first few weeks to months of life and are the most common causes of stridor (87%).[medicine.uiowa.edu] Associated findings include gastroesophageal reflux, obstructive and central apnea, hypotonia, failure to thrive, and pneumonitis.[ncbi.nlm.nih.gov] […] headache, memory impairment, cerebrospinal bleeding, hyponatremia, syndrome of inappropriate antidiuretic hormone secretion, nausea and vomiting, uterine rupture, neonatal hyperbilirubinemia[ccforum.biomedcentral.com]

  • Glycogen Storage Disease Type 2

    Infantile GSDII presents during the first weeks or months of life with poor feeding, failure to thrive, macroglossia, severe hypotonia, cardiomegaly, mild hepatomegaly, and[genedx.com] Deletion Syndrome, Adrenoleukodystrophy, Critical Congenital Heart Disease, Fabry Disease, Hemoglobin H, Krabbe Disease, MPS 1 (alpha-L-idurinidase deficiency), Neonatal Hyperbilirubinemia[us5.campaign-archive1.com] […] fixed myopathy in some patients Systemic features Gout: Hyperuricemia Gastric ulcer Laboratory Serum CK During episodes: High Between episodes: Often normal Hyperuricemia Hyperbilirubinemia[neuromuscular.wustl.edu]

  • Glycogen Storage Disease

    Infantile GSDII presents during the first weeks or months of life with poor feeding, failure to thrive, macroglossia, severe hypotonia, cardiomegaly, mild hepatomegaly, and[genedx.com] BACKGROUND: Glycogen storage disease type VI (GSD-VI) presents with failure to thrive and also fibrosis in some cases, without cirrhosis.[ncbi.nlm.nih.gov] […] fixed myopathy in some patients Systemic features Gout: Hyperuricemia Gastric ulcer Laboratory Serum CK During episodes: High Between episodes: Often normal Hyperuricemia Hyperbilirubinemia[neuromuscular.wustl.edu]

  • Intrahepatic Cholestasis

    Clinical description The first cholestatic episode can occur at any age but onset within the first two decades of life is most common.[orpha.net] The other more variable features included failure to thrive, bleeding diathesis, hypoproteinaemia, abnormal liver enzymes, prolonged coagulation profile, hyperammonaemia,[ncbi.nlm.nih.gov] Dubin-Johnson syndrome may manifest as conjugated hyperbilirubinemia, darkly pigmented liver, presence of abnormal pigment in the parenchyma of hepatocytes and abnormal distribution[ncbi.nlm.nih.gov]

  • Volvulus

    The onset occurred in the first week of life in 3 patients, at age 1.5 months in another, and at age 5 months in the last one, although the latter had previously visited the[analesdepediatria.org] Feeding problems resulting from recurrent vomiting were associated with failure to thrive.[karger.com] Abdominal pain (RUQ, radiates epigastric), nausea, vomiting, fever, Murphy's sign Clinical (history & physical exam) Imaging (RUQ ultrasound) Labs ( leukocytosis, transamintis, hyperbilirubinemia[en.wikipedia.org]

  • Neonatal Sepsis

    Early-onset sepsis is seen in the first week of life. Occurs after 1 week and before 3 months of age.[omicsonline.org] Children develope failure to thrive, developemental dalay, anemia, oral thrush, chronic diarrhea.[atlases.muni.cz] The incidence rate of hyperbilirubinemia due to infection is unknown (7,8).[ijp.mums.ac.ir]

  • Neonatal Infection

    Early-onset sepsis is seen in the first week of life. Late onset sepsis occurs after 1 week through 3 months of age.[mountsinai.org] […] to thrive, hepatosplenomegaly, neurologic abnormalities).[merckmanuals.com] […] low-risk for having a serious bacterial illness: [2] generally well-appearing previously healthy full term (at 37 weeks gestation) no antibiotics perinatally no unexplained hyperbilirubinemia[en.wikipedia.org]

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