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240 Possible Causes for Failure to Thrive, Increased Susceptibility to Infections, Recurrent Otitis Media

  • Primary Immune Deficiency Disorder

    The most common symptom of PIDD is an increased susceptibility to infection.[symptoma.com] Scarred tympanic membranes or chronic perforation due to recurrent otitis media is commonly seen in patients with antibody deficiencies.[worldallergy.org] Diarrhea, failure to thrive, opportunistic infections, and severe routine infections in a child younger than three months should raise suspicion for SCID.[aafp.org]

  • Shwachman Syndrome

    Affected individuals with neutropenia may also have additional abnormalities believed to result from an increased susceptibility to infections.[rarediseases.org] Exocrine pancreatic insufficiency results in failure to thrive, growth retardation, and chronic steatorrhea.[orpha.net] otitis media, mastoiditis, and two episodes of pneumonia.[journals.plos.org]

  • Severe Combined Immunodeficiency

    Primary immunodeficiencies (PIDs) represent a large group of disorders with an increased susceptibility to infections.[ncbi.nlm.nih.gov] Patients usually present in first 6 months of life with respiratory/gastrointestinal tract infections and failure to thrive.[ncbi.nlm.nih.gov] He has also experienced recurrent episodes of otitis media from repeat Streptoccous pneumoniae. He notably has reduced T and B cell counts.[medbullets.com]

  • Common Variable Immunodeficiency

    susceptibility to infections.[ncbi.nlm.nih.gov] This case report describes a 10-year-old boy presenting with signs of common variable immunodeficiency (CVID), failure to thrive, impaired neurological development, and a[ncbi.nlm.nih.gov] Antibody immunodeficiencies are marked by hypo- or dysgammaglobulinemia, recurrent bacterial otitis media, and sinopulmonary infections.[medical-dictionary.thefreedictionary.com]

  • Gastroesophageal Reflux Disease

    Conclusions Severe hypochlorhydria generated by PPI use leads to bacterial colonisation and increased susceptibility to enteric bacterial infection.[dx.doi.org] In pediatrics, the presentation is often non-specific, with vomiting, upper and lower respiratory symptoms, irritability, aversion to food, and failure to thrive 2 .[radiopaedia.org] Conversely, no conclusive clinical evidence supports a link between gastroesophageal reflux and other supraesophageal problems, including otalgia, recurrent otitis media,[emedicine.medscape.com]

  • Congenital Acquired Immune Deficiency Syndrome

    KEY TERMS Agammaglobulinemia —The lack of gamma globulins in the blood, associated with an increased susceptibility to infection.[healthofchildren.com] Encephalopathic findings such as failure to thrive and impaired brain growth, as well as the presence of motor deficits (paresis, ataxia, gait disturbance or abnormal reflexes[symptoma.com] Antibody immunodeficiencies are marked by hypo- or dysgammaglobulinemia, recurrent bacterial otitis media, and sinopulmonary infections.[medical-dictionary.thefreedictionary.com]

  • Kabuki Syndrome

    In particular, most KS patients show increased susceptibility to infections and have reduced serum immunoglobulin levels, while some suffer also from autoimmune manifestations[ncbi.nlm.nih.gov] Other common symptoms are skeletal abnormalities, short stature, heart defects, feeding difficulties and a failure to thrive, vision and hearing difficulties, weak muscle[senteacher.org] otitis media.[ncbi.nlm.nih.gov]

  • HIV Infection

    Fig 3. eSF enhance HIV infection more potently than DCs in a manner involving both trans -infection and increased susceptibility of T cells to HIV infection.[journals.plos.org] They may present with recurrent infections of the respiratory tract, including otitis media, tonsillitis, sinusitis, pharyngitis, and bronchitis.[symptoma.com] HIV infection increases susceptibility to smoking-induced emphysema. Chest. 2000;117(5 suppl 1):285S. 33. Kirk GD, Merlo C, O'Driscoll P, et al.[aafp.org]

  • Hypogammaglobulinemia

    susceptibility to pyogenic infections.[medical-dictionary.thefreedictionary.com] Other important presenting symptoms may include failure to thrive in children, chronic diarrhea, and complications after receiving live vaccines.[online.epocrates.com] Case description: A 41-year-old female with TS, hypothyroidism, and recurrent otitis media as a child presents with severe vitamin deficiencies including: iron, vitamin B12[eposters.net]

  • Mucopolysaccharidosis 2

    Until two decades ago, HSCT had high mortality rates because of (1) the preconditioning regimen prior to HSCT, which caused severe side effects including increased susceptibility[ncbi.nlm.nih.gov] otitis media Broad chest Ivory-colored papular skin lesions on the upper back and sides of the upper arms Protuberant abdomen Diarrhea Short stature Skeletal deformities[symptoma.com] Recurrent otitis media is a frequent problem and may lead to conductive hearing impairment.[actamedicaphilippina.com.ph]

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