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67 Possible Causes for Failure to Thrive, Thickening of the Mitral Valve Leaflets

  • Mucopolysaccharidosis

    […] multiorgan deterioration that includes hepatosplenomegaly, dysostosis multiplex, short stature, coarse facial features, corneal clouding, joint contractures, umbilical hernias, failure[] […] to thrive, intellectual disability, and developmental delay.[ 5 12 ] The extensive storage of these glycosaminoglycans is also known to cause meningeal thickening.[ 4 ] Intraoperatively[]

  • Mucopolysaccharidosis 1 H-S

    Progressive thickening and stiffening of the valve leaflets can lead to mitral and aortic regurgitation, which may become hemodynamically significant in the later stages of[]

  • Mitral Valve Insufficiency

    In children, failure to thrive is an important hallmark of almost all serious heart conditions.[] Abstract Mitral valve insufficiency in rheumatic heart disease is often due to retracted posterior chordae and posterior leaflet thickening.[] valve prolapse were classified into two groups: those with thickening and redundancy of the mitral valve leaflets ("classic") and those without ("non classic") in an attempt[]

  • Noonan Syndrome

    […] to thrive, short stature, feeding difficulties, sternal deformity, renal malformation, pubertal delay, cryptorchidism, developmental or behavioral problems, vision problems[] Transthoracic echocardiography revealed thickening of all the four valves.[] The patient presented with postnatal-onset failure-to-thrive, developmental delay, microcephaly, velopalatal incompetence, pectus excavatum, coarctation of aorta, atrial and[]

  • Lutembacher Syndrome

    It is severe ASD therefore Clinical features at 6 - 10 wks Failure to thrive Recurrent infections Feeding difficulties CHF ECG : Left axis deviation.[] Note the thickened, narrowed, and calcified mitral valve apparatus and doming of the anterior leaflet of the mitral valve.[] Note severely dilated left atrium, calcified and thickened mitral valve leaflets, doming of the anterior mitral valve leaflet, mitral annular calcification, and reduced opening[]

  • Atrioventricular Septal Defect

    The main symptoms are feeding problems, failure to thrive and frequent pulmonary infections. The symptoms are similar to those caused by a large VSD.[] In the midesophageal long-axis view, remnants of mitral valve chordae originating from the base of the thickened anterior mitral leaflet and attached to the interventricular[] Infants may present with congestive heart failure , tachypnea , excessive sweating, failure to thrive, extremis with acidosis , severe hypoplasia of left-sided structures[]

  • Congenital Mitral Stenosis

    All were symptomatic with severe congestive heart failure and failure to thrive. Effective reduction in mitral gradient was initially achieved in 7 patients.[] Definition (CSP) rheumatic disease causing diffuse thickening of the mitral valve leaflets by fibrous tissue or calcific deposits.[] On detailed evaluation, it was found that the child had severe breathlessness, feeding difficulty, failure to thrive and recurrent respiratory tract infection.[]

  • Mucopolysaccharidosis 2

    Fig. 1 Subcostal echocardiographic view showing anterior (arrowhead) and posterior mitral valve thickening with subvalvular involvement (asterisk).[] The GAGs accumulation affects the subvalvular and valvular structures producing a distal thickening of the leaflets, loss of mobility and valve regurgitation, especially of[] The echocardiogram revealed a preserved and nonhypertrophic left ventricle with a severe mitral valve regurgitation in relation to subvalvular and valvular thickening, retraction[]

  • Endocardial Fibroelastosis

    Symptoms - Endocardial fibroelastosis Breathlessness Cough Wheezing Feeding difficulty Excessive sweating Failure to thrive Recurrent chest infections (20%) Causes - Endocardial[] Primary EFE is characterized by a dilated left ventricle (LV) that typically has a high takeoff of the papillary muscles and thickening of the free edge of the mitral valve[] Once regarded as a common cause of unexplained heart failure, EFE is now considered rare.[]

  • Marchesani-Weill Syndrome

    At operation we found thickened mitral valve leaflets and chordal apparatus and mitral valve repair was done as described earlier.[] Two infant brothers presented with progressive severe mitral valve stenosis and pulmonary hypertension with a need for operation.[]

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