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28 Possible Causes for Failure to Thrive, Wide Space Between the First and Second Toe

  • Down Syndrome

    Symptoms included constipation (20%), gastroesophageal reflux (18%), failure to thrive (10%), diarrhea (6%), and extreme short stature (4%).[journals.lww.com] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] spacing, often with a deep plantar groove between the first and second toes.[doi.org]

  • Dubowitz Syndrome

    Afterwards, the child is sometimes labeled as failure to thrive . The head is usually microcephalic and face is small with some elongation with age.[dubowitzsyndrome.net] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Failure to Thrive : growth failure, or failure to thrive (FTT), is a descriptive term and not a specific diagnosis.[ric.edu]

  • Russell-Silver Syndrome

    Mosaic trisomy 7 was diagnosed after birth, on fibroblasts karyotype performed for blaschkolinear pigmentary skin anomalies and failure to thrive.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Russell-Silver syndrome is characterized by asymmetric intrauterine growth retardation, postnatal failure to thrive, distinct facial features, limb asymmetry, excessive sweating[ncbi.nlm.nih.gov]

  • Ring Chromosome 10

    They showed a phenotype consistent with the “ring syndrome” with failure to thrive, minor dysmporphic features and no major anomalies.[tp.amegroups.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] It had feeding difficulties and failed to thrive and had a respiratory arrest at 4 months.[tp.amegroups.com]

  • Cutis Laxa

    […] to thrive, developmental delay, dysmorphism, osseous abnormality, and CNS manifestations.[ncbi.nlm.nih.gov] Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br] Features of our patient that have been described in literature included cutis laxa on hands and feet, visible veins on thorax and abdomen, joint laxity, failure to thrive,[ncbi.nlm.nih.gov]

  • Weaver Syndrome

    Pediatr Radiol 5:53–57 Google Scholar Marshall RE, Graham CB, Scott CR, Smith DW (1971) Syndrome of accelerated skeletal maturation and relative failure of thrive: A newly[link.springer.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Widened middle and proximal phalanges, failure to thrive, craniofacial abnormalities (small face, prominent eyes, blue sclera, flat nose with anteverted nares, choanal atresia[icd10data.com]

  • Kenny-Caffey Syndrome Type 1

    CASE REPORT A 7-month-old girl was admitted to the children hospital in Damascus for the first time complaining of failure to thrive.[ncbi.nlm.nih.gov] space between the first and second toes.[medcraveonline.com] […] to thrive hypoparathyrodism, dysmorphic facies, characteristic bone changes and mild mental retardation.[ncbi.nlm.nih.gov]

  • Atelosteogenesis Type 2

    In addition to the respiratory difficulties, feeding difficulties can result in a failure to thrive. The severity of airway compromise dictates management.[oralmaxillo-facialsurgery.blogspot.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and[rarediseases.info.nih.gov]

  • Multiple Endocrine Neoplasia Type 2B

    Feeding difficulties--poor suck to the point of failure to thrive--were present in the neonatal periods of seven of our nine patients who had MEN 2b.[ncbi.nlm.nih.gov] Figure 3 The first toe is longer than the others and there is a wide space between the first and second toe.[ijponline.biomedcentral.com] The typical clinical features consist of somatic abnormalities: failure to thrive, characteristic facies, excessive sweating, labile blood pressure, recurrent aspiration pneumonias[ncbi.nlm.nih.gov]

  • Growth Delay due to Insulin-Like Growth Factor I Resistance

    […] to thrive Faltering weight Weight faltering [ more ] 0001508 Insulin resistance Body fails to respond to insulin 0000855 Intellectual disability, mild Mental retardation,[rarediseases.info.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Childhood attention deficit/hyperactivity disorder [ more ] 0007018 Bilateral sensorineural hearing impairment 0008619 Congenital sensorineural hearing impairment 0008527 Failure[rarediseases.info.nih.gov]

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