Create issue ticket

52 Possible Causes for Fainting Spells, Tryptophan Increased

  • Hepatic Encephalopathy

    Benzodiazepine-like compounds have been detected at increased levels as well as abnormalities in the GABA neurotransmission system.[en.wikipedia.org] Increased production of endogenous BZPs has been proposed.[emedicine.medscape.com] An imbalance between aromatic amino acids (phenylalanine, tryptophan and tyrosine) and branched-chain amino acids (leucine, isoleucine and valine) has been described; this[en.wikipedia.org]

  • Hartnup Disease

    As a result, the concentration of tryptophan increases in the urine and decreases in the blood, and there is less tryptophan available for the synthesis of niacin.[britannica.com] An oral challenge with 200 mg/kg of tryptophan ethyl ester resulted in a prompt increase in serum tryptophan to a peak of 555 microM.[ncbi.nlm.nih.gov] In Hartnup disease, it is believed that the transport system in the kidney tubule that normally reabsorbs tryptophan into the body circulation is defective.[britannica.com]

  • Toxoplasmosis

    At least some of these effects, possibly mediated by increased dopamine and decreased tryptophan, are products of manipulation activity by Toxoplasma aiming to increase the[ncbi.nlm.nih.gov] tryptophan levels in all brain regions ( Dunn, 2006 ) or alternatively there are only proximate effects on serotonin in the specific area surrounding the cysts.[doi.org] Irritability rather than depression during interferon treatment is linked to increased tryptophan catabolism.[ncbi.nlm.nih.gov]

  • Hyponatremia

    The administration of antegrade single-shot, up to two liters, histidine-tryptophane-ketoglutarate (HTK) solution for adequate electromechanical cardiac arrest and myocardial[cardiothoracicsurgery.biomedcentral.com] 10 June 2012 Published: 10 June 2012 Abstract Background Hyponatremia is the most common electrolyte disorder in hospitalized patients and is known to be associated with increased[cardiothoracicsurgery.biomedcentral.com]

  • Migraine

    Tryptophan depletion increases nausea, headache and photophobia in migraine sufferers. Cephalalgia 2006 ; 26: 1225 – 33. Google Scholar SAGE Journals ISI 30.[doi.org] Effect of tryptophan depletion on symptoms of motion sickness in migraineurs. Neurology 2005 ; 65: 620 – 2. Google Scholar Crossref Medline ISI 29. Drummond, PD.[doi.org]

  • Fibromyalgia

    […] blood flow to the thalamus region of the brain, low levels of serotonin and tryptophan and abnormalities in cytokine function ref 5.[hopkinsarthritis.org] For example, levels of brain tryptophan, the amino acid precursor of serotonin, is markedly increased by exposure to insulin injection in fasted rats (metabolic stressor),[arthritis-research.com] FMS patients show an augmented prolactin response to a buspirone challenge test, suggesting an increased sensitivity or density of dopamine D2 receptors [ 29 ].[doi.org]

  • Chronic Fatigue Syndrome

    IL-1β also increases brain tryptophan concentrations and the rate of 5- hydroxytryptamine (5-HT) metabolism, which may further activate the HPA axis [ 154 ].[doi.org] Leptin, like melatonin, is a wide immune regulator, increasing natural killer cell activity and Th1 responses, while inhibiting the cAMP induction of tryptophan 2,3-dioxygenase[doi.org] The severity of ME/CFS is associated with increased indicants of metabolic syndrome [ 177 ], suggesting that wider metabolic dysregulation associated with obesity and leptin[doi.org]

  • Drug Hypersensitivity

    The peptides were radiolabeled and tested for binding in increasing concentrations of abacavir.[pnas.org] […] when the C-terminal P9 residue is switched to a tryptophan (pep-W), and that this effect is not observed for control HLA alleles.[pnas.org] As a control, pep-W with a C-terminal tryptophan was expected to be able to bind HLA-B*57:01 readily in the presence or absence of abacavir.[pnas.org]

  • Olivopontocerebellar Atrophy

    Dx increased serum tryptophan Wernike encephalopathy Thiamine deficiency due to malnutrition, or Alcoholism Congenital (I.E. present at Birth) A variety of structural brain[cmdg.org] MSA is a progressive neurodegenerative disorder characterized by symptoms of autonomic nervous system failure (such as lightheadedness or fainting spells, constipation, erectile[msa-ams.be] Dx increased serum Phytanic acid Tryptophanuria Ataxia, photosensitivity, short stature, and mental retardation.[cmdg.org]

  • Porphyria

    Decreased activity of the heme-dependent protein tryptophan pyrrolase in the liver supposedly increases central and systemic tryptophan levels due to decreased tryptophan[emedicine.medscape.com] Increased central 5-hydroxytryptamine levels may cause cognitive changes.[emedicine.medscape.com]

Further symptoms