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7 Possible Causes for falcipain

  • Sulfone

    New compounds 2-3 have been proven to be potent and selective inhibitors of falcipain-2, a cysteine protease isolated from Plasmodium falciparum, displaying antiplasmodial[]

  • Suramin

    Abstract Falcipain-2 is a cysteine protease of the malaria parasite Plasmodium falciparum that plays a key role in the hydrolysis of hemoglobin, a process that is required[] In this work we show that the polysulfonated napthylurea suramin is capable of binding to falcipain-2, inhibiting its catalytic activity at nanomolar concentrations against[] Our results identify the suramin family as a potential starting point for the design of falcipain-2 inhibitor antimalarials that act through a novel inhibition mechanism.[]

  • Plasmodium

    The Plasmodium contains members of Plasmapepsin family (Aspartic proteinase), Falcipain family (Cysteine Proteases), and Falcilysin (a metallo peptidase), which have been[] Possible candidates for this mechanism include cysteine proteinases of the falcipain and SERA families, or subtilisins such as SUB1 and SUB2, both located in apical organelles[]

  • Plasmodium Falciparum Malaria

    Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites . Proc. Natl Acad. Sci. USA 101 , 8721–8726 (2004) 58.[] Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum . Mol. Biochem. Parasitol. 150 , 96–106 (2006) 59.[]

  • Chloroquine

    In the P. falciparum DV, there are four aspartic proteases (plasmepsins) and two papain-like cysteine proteases (falcipains) capable of hydrolyzing native Hb ( Goldberg, 2005[] […] the aspartic protease, plasmepsin 4 (PM4), a single enzyme equivalent to the 4 P. falciparum plasmepsins (PM1–4); berghepain-2 (BP2), equivalent to the 2 P. falciparum DV falcipains[] Footnotes Abbreviations used: AS artesunate BP berghepain CQ chloroquine DV digestive vacuole FP falcipain Hb hemoglobin Hz hemozoin iRBC infected red blood cell PM plasmepsin[]

  • Doxycycline

    Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3. Biochem. J. 360 : 481 -489. Smeijsters, L. J., N. M. Zijlstra, E. de Vries, F.[] The blots were stripped and reprobed with a 1:10,000 dilution of rat anti-falcipain-3 antibody ( 31 ), followed by alkaline phosphatase-conjugated goat anti-rat antibody ([] The expression and processing of the nuclear-encoded cysteine protease falcipain-3 was unaffected by doxycycline, demonstrating that the inability of parasites to process[]

  • Telmisartan

    Probing the structure of falcipain-3, a cysteine protease from Plasmodium falciparum : comparative protein modeling and docking studies. Prot Sci . 2003; 12 : 501–509.[]

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