In the familial form of ALS several genes mutations have been identified (e.g. SOD1, TDP-43, FUS, and the hexanucleotide repeat expansion in C9ORF72 ) 5.
form of the disease some map to gene for superoxide dismutase on chromosome 21 Presentation Symptoms painless weakness in one extremity that extends to the other extremities
ALS, formally known as amyotrophic lateral sclerosis and informally as Lou Gehrig's disease, occurs in both a less common familial form (i.e. an inherited form, known as ALS1