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88 Possible Causes for Family History of Hypercholesterolemia, Tendon Xanthomas

  • Familial Hypercholesterolemia

    The case presented here is of a 48-year old male with large tendon xanthomas attributable to CTX.[ncbi.nlm.nih.gov] Clinical features found among these 27 patients were: xanthelasma in 5 (18.5%), corneal arcus in 1 (3.7%), coronary artery disease (CAD) in 10 (37%), and a family history[ncbi.nlm.nih.gov] An 11-year-old female without any family histories of hypercholesterolemia was referred to our hospital to make clinical as well as molecular diagnoses.[ncbi.nlm.nih.gov]

  • Heterozygous Familial Hypercholesterolemia

    Sixty-two patients had positive physical examination findings for Achilles tendon xanthomas.[ajronline.org] history — Early onset CVD — Hyperlipidemia, often requiring treatment HOW IS FAMILIAL HYPERCHOLESTEROLEMIA DIAGNOSED?[geneticseducation.ca] Tendon xanthomas are cholesterol deposits on tendons that can be felt as bumps on the surface of the backs of the heels and fingers.[ahajournals.org]

  • Hypercholesterolemia

    Xanthomas are noted commonly on the Achilles tendons and metacarpal phalangeal extensor tendons of the hands.[emedicine.medscape.com] Clinical diagnosis is based on a set of clinical criteria including lipid panel testing, personal and family history of hypercholesterolemia or premature ASCVD, presence of[phekb.org] The likelihood of FH is higher in individuals with a positive family history of hypercholesterolemia or of premature CHD (onset in men before age 55 years and women before[beta.labcorp.com]

  • Homozygous Familial Hypercholesterolemia

    The condition is characterized by exceptionally high LDL cholesterol levels, cutaneous and tendon xanthomas, and valvular and supravalvular stenosis, and accelerated atherosclerosis[ncbi.nlm.nih.gov] On examination, he was found to have multiple planar and tendinous xanthomas, an (LDL) cholesterol level of 24.6 mmol/l and family history of hypercholesterolemia.[ncbi.nlm.nih.gov] Xanthomas The high cholesterol level may result in the build-up of cholesterol deposits in the skin and tendons as well – xanthomas.[aoporphan.com]

  • Familial Hyperlipidemia

    His physical exam is normal and there is no tendon xanthomas or corneal arcus. Familial hypercholesterolemia (FH) is suspected.[knowledge.statpearls.com] […] deficiency, disorder of lipoprotein metabolism, unspecified and family history of familial hypercholesterolemia.[blueprintgenetics.com] Image of tendon xanthoma, a pathognomonic physical examination finding in patients with familial hypercholesterolemia. Figure.[jaoa.org]

  • Sterol 27-Hydroxylase Deficiency

    […] levels may also be reduced or normal), neurological symptoms and tendon xanthomas.[symptoma.com] Effect of lipid-lowering treatment on natural history of heterozygous familial hypercholesterolemia in past three decades. Am J Cardiol. 2011;108:223–6.[genereviews.nrdrs.org.cn] Tendon xanthomas may cause discomfort and interfere with tendon flexibility.[ghr.nlm.nih.gov]

  • Hyperlipoproteinemia

    Achilles tendon xanthomas are often associated with type II hyperlipoproteinemia, in which low-density lipoprotein derived from the circulation accumulates in the tendons.[ncbi.nlm.nih.gov] She had no disease associated with secondary hypercholesterolemia and no family history of hypercholesterolemia.[ncbi.nlm.nih.gov] Abstract We describe an adult patient with type IIa hyperlipoproteinemia, presenting with Achilles tendon xanthomas, cataracts, dementia, ataxia, pyramidal tract signs, and[ncbi.nlm.nih.gov]

  • Hyperlipidemia Type 5

    Simon-Broome and Dutch criteria utilize lipid profiles, history of premature CVD, and physical examination findings such as tendon xanthomas from both the patient and family[acc.org] hypercholesterolemia Tendinous xanthomas, cornial arcus, premature CAD; family history of hypercholesterolemia 0.2% of general population; 5% of MI survivors under age 60[what-when-how.com] There may be: A strong family history of familial hypercholesterolemia or early heart attacks High level of LDL cholesterol in either or both parents People from families[medlineplus.gov]

  • Hyperlipoproteinemia Type 4

    Clinical findings: Tendon xanthomas, Xanthelasma, premature coronary artery disease and stroke.[medicowesome.com] , combined familial hyperlipoproteinemia, and familial hypercholesterolemia.[ajnr.org] Simon-Broome and Dutch criteria utilize lipid profiles, history of premature CVD, and physical examination findings such as tendon xanthomas from both the patient and family[acc.org]

  • Disorder of Lipid Metabolism

    Familial hypercholesterolaemia (FH), which may present with xanthelasma ( Fig 67.1 ), tendon xanthomas, severe hypercholesterolaemia and premature coronary heart disease,[clinicalgate.com] The family history is frequently positive for premature ASCVD on one side of the family.[thoracickey.com] The buildup of fats leads to atherosclerosis, early coronary artery disease, abnormal red blood cells, and xanthomas on tendons.[merckmanuals.com]

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