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88 Possible Causes for Family History of Hypercholesterolemia, Tendon Xanthomas

  • Familial Hypercholesterolemia

    The case presented here is of a 48-year old male with large tendon xanthomas attributable to CTX.[] Clinical features found among these 27 patients were: xanthelasma in 5 (18.5%), corneal arcus in 1 (3.7%), coronary artery disease (CAD) in 10 (37%), and a family history[] An 11-year-old female without any family histories of hypercholesterolemia was referred to our hospital to make clinical as well as molecular diagnoses.[]

  • Heterozygous Familial Hypercholesterolemia

    Sixty-two patients had positive physical examination findings for Achilles tendon xanthomas.[] history — Early onset CVD — Hyperlipidemia, often requiring treatment HOW IS FAMILIAL HYPERCHOLESTEROLEMIA DIAGNOSED?[] Tendon xanthomas are cholesterol deposits on tendons that can be felt as bumps on the surface of the backs of the heels and fingers.[]

  • Hypercholesterolemia

    Xanthomas are noted commonly on the Achilles tendons and metacarpal phalangeal extensor tendons of the hands.[] Clinical diagnosis is based on a set of clinical criteria including lipid panel testing, personal and family history of hypercholesterolemia or premature ASCVD, presence of[] The likelihood of FH is higher in individuals with a positive family history of hypercholesterolemia or of premature CHD (onset in men before age 55 years and women before[]

  • Homozygous Familial Hypercholesterolemia

    The condition is characterized by exceptionally high LDL cholesterol levels, cutaneous and tendon xanthomas, and valvular and supravalvular stenosis, and accelerated atherosclerosis[] On examination, he was found to have multiple planar and tendinous xanthomas, an (LDL) cholesterol level of 24.6 mmol/l and family history of hypercholesterolemia.[] Xanthomas The high cholesterol level may result in the build-up of cholesterol deposits in the skin and tendons as well – xanthomas.[]

  • Familial Hyperlipidemia

    His physical exam is normal and there is no tendon xanthomas or corneal arcus. Familial hypercholesterolemia (FH) is suspected.[] […] deficiency, disorder of lipoprotein metabolism, unspecified and family history of familial hypercholesterolemia.[] Image of tendon xanthoma, a pathognomonic physical examination finding in patients with familial hypercholesterolemia. Figure.[]

  • Sterol 27-Hydroxylase Deficiency

    […] levels may also be reduced or normal), neurological symptoms and tendon xanthomas.[] Effect of lipid-lowering treatment on natural history of heterozygous familial hypercholesterolemia in past three decades. Am J Cardiol. 2011;108:223–6.[] Tendon xanthomas may cause discomfort and interfere with tendon flexibility.[]

  • Hyperlipoproteinemia

    Achilles tendon xanthomas are often associated with type II hyperlipoproteinemia, in which low-density lipoprotein derived from the circulation accumulates in the tendons.[] She had no disease associated with secondary hypercholesterolemia and no family history of hypercholesterolemia.[] Abstract We describe an adult patient with type IIa hyperlipoproteinemia, presenting with Achilles tendon xanthomas, cataracts, dementia, ataxia, pyramidal tract signs, and[]

  • Hyperlipidemia Type 5

    Simon-Broome and Dutch criteria utilize lipid profiles, history of premature CVD, and physical examination findings such as tendon xanthomas from both the patient and family[] hypercholesterolemia Tendinous xanthomas, cornial arcus, premature CAD; family history of hypercholesterolemia 0.2% of general population; 5% of MI survivors under age 60[] There may be: A strong family history of familial hypercholesterolemia or early heart attacks High level of LDL cholesterol in either or both parents People from families[]

  • Hyperlipoproteinemia Type 4

    Clinical findings: Tendon xanthomas, Xanthelasma, premature coronary artery disease and stroke.[] , combined familial hyperlipoproteinemia, and familial hypercholesterolemia.[] Simon-Broome and Dutch criteria utilize lipid profiles, history of premature CVD, and physical examination findings such as tendon xanthomas from both the patient and family[]

  • Disorder of Lipid Metabolism

    Familial hypercholesterolaemia (FH), which may present with xanthelasma ( Fig 67.1 ), tendon xanthomas, severe hypercholesterolaemia and premature coronary heart disease,[] The family history is frequently positive for premature ASCVD on one side of the family.[] The buildup of fats leads to atherosclerosis, early coronary artery disease, abnormal red blood cells, and xanthomas on tendons.[]

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