Fasting Hypoglycemia: Causes & Reasons

Possible Causes for Fasting Hypoglycemia

Fasting hypoglycemia Nesidioblastosis is a rare cause of fasting hypoglycemia in infants and an extremely rare cause in adults. [emedicine.medscape.com]

The 2 types of non-diabetic hypoglycemia are fasting hypoglycemia and reactive hypoglycemia. [drugs.com]

Rare hereditary enzyme deficiencies can lead to fructose intolerance and reactive hypoglycemia. 3 Fasting (Postabsorptive) Hypoglycemia This condition may be diagnosed when [uspharmacist.com]

Alcohol-Induced Hypoglycemia

For fasting hypoglycemia, you may have your blood glucose checked every few hours during a fast lasting several days. [hormone.org]

The 2 types of non-diabetic hypoglycemia are fasting hypoglycemia and reactive hypoglycemia. [drugs.com]

Fasting Hypoglycemia Fasting hypoglycemia can be a life threatening condition. [ocw.tufts.edu]

Fructose-1,6-Bisphosphatase Deficiency

• A girl aged 3 years and 11 months, with recurrent episodes of unexplained metabolic acidosis, hepatomegaly, and fasting hypoglycemia unresponsive to glucagon, showed profound [jamanetwork.com]

Deficiency of fructose-1,6-bisphosphatase is associated with fasting hypoglycemia and metabolic acidosis because of impaired gluconeogenesis. [experts.umn.edu]

Without treatment, affected people can experience hypoglycemia and metabolic acidosis on fasting, episodes of hyperventilation, suspension of breathing (apnea), and elevated [rarediseases.info.nih.gov]

Glycogen Storage Disease

Glycogen storage disease type Ia is a genetic disorder that is associated with persistent fasting hypoglycemia and the inability to produce endogenous glucose. [ncbi.nlm.nih.gov]

[…] may be partially impaired, resulting in an increased risk of mild fasting hypoglycemia and associated hyperketosis. [emedicine.medscape.com]

The management of glycemic control remains a clinical challenge, requiring management of both fasting hypoglycemia from glycogen storage disease, as well as post-prandial [ncbi.nlm.nih.gov]

Glycogen Storage Disease Type 1

Most patients have the typical combination of clinical symptoms: hepatomegaly secondary to glycogen accumulation, glucose and galactose intolerance, fasting hypoglycemia, [doi.org]

MEASUREMENTS AND RESULTS: The main laboratory findings were fasting hypoglycemia and massive glucosuria, with evidence of multiple renal tubular dysfunction characteristic [ncbi.nlm.nih.gov]

—The main laboratory findings were fasting hypoglycemia and massive glucosuria, with evidence of multiple renal tubular dysfunction characteristic of the Fanconi syndrome. [jamanetwork.com]

Glycogen Storage Disease Type 0

The diagnosis of GSD0 should be considered in a child with ketotic fasting hypoglycemia with postprandial hyperglycemia but without hepatomegaly. [ncbi.nlm.nih.gov]

Mortality/Morbidity The major morbidity is a risk of fasting hypoglycemia, which can vary in severity and frequency. [emedicine.com]

Patients typically have hypoglycemia and ketosis, with lactate and alanine levels in the low or normal part of the reference range approximately 5–7 hours after fasting. [en.wikipedia.org]

Glycogen Storage Disease Type 6

[…] may be partially impaired, resulting in an increased risk of mild fasting hypoglycemia and associated hyperketosis. [emedicine.medscape.com]

These children may also have histories of mild fasting hypoglycemia and hypotonia. [humpath.com]

Individuals with GSD VI typically exhibit hepatomegaly, growth retardation, and variable but mild episodes of fasting hypoglycemia and hyperketosis during early childhood. [emedicine.medscape.com]

Glycogen Storage Disease Type 3

GSD III is characterized by fasting hypoglycemia, hepatomegaly, growth retardation, progressive myopathy, and cardiomyopathy due to storage of abnormally structured glycogen [ncbi.nlm.nih.gov]

Serum analysis showed mild fasting hypoglycemia (values of 40–45 mg/dL, without increase in glycemia after glucagon load following an overnight fast), hyperlipidemia (triglycerides [journals.lww.com]

Fasting hypoglycemia and ketonuria may be noted. Hyperlipidemia may be present as well. Elevated Serum aminotransferase and CK levels are normal. [symptoma.com]

Insulinoma

We report a rare case of an insulinoma diagnosed in an individual presenting exclusively with postprandial hypoglycemia without fasting hypoglycemia. [ncbi.nlm.nih.gov]

Most patients (n=18, 62.1%) had fasting hypoglycemia, about a third (31%) both postprandial and fasting hypoglycemia, and 6.9% postprandial hypoglycemia only. [ncbi.nlm.nih.gov]

The patient had no symptoms of hypoglycemia during the fast, and her plasma glucose level remained above 60 mg/dL. [healio.com]

Long Chain Hydroxyacyl-CoA Dehydrogenase Deficiency

[…] hypoketotic hypoglycemia, exercise-induced rhabdomyolysis, cardiomyopathy, cholestatic liver disease, retinopathy, maternal HELLP syndrome Treatment: Avoidance of fasting [merckmanuals.com]

A common characteristic of all these cases (except those involving short-chain and, on occasions, medium-chain) is hypoketotic hypoglycemia with fasting. [revespcardiol.org]

Treatment : It is important to avoid fasting to prevent hypoketotic hypoglycemia. [emilytam.com]

Medium Chain Acyl CoA Dehydrogenase Deficiency

Clinical manifestations thus include fasting hypoglycemia, severe metabolic acidosis, and hyperammonemia. [merckmanuals.com]

BACKGROUND: Impairments in gluconeogenesis have been implicated in the pathophysiology of fasting hypoglycemia in medium-chain acyl-CoA dehydrogenase deficiency. [ncbi.nlm.nih.gov]

Three children in two families presented in early childhood with episodes of illness associated with fasting which resembled Reye's syndrome: coma, hypoglycemia, hyperammonemia [ncbi.nlm.nih.gov]

Neonatal Hypoglycemia

Excluding insulin therapy, almost all hypoglycemia in childhood occurs during fasting. [emedicine.medscape.com]

Insulin injection and fasting both could induce consistent hypoglycemia in newborn rats. [ncbi.nlm.nih.gov]

Postprandial hypoglycemia is rare in children in the absence of prior gastrointestinal (GI) surgery. [emedicine.medscape.com]

Carnitine Transporter Deficiency

Lack of carnitine impairs mitochondrial fatty acid oxidation and can result in fasting-induced hypoketotic hypoglycemia usually associated with hepatic dysfunction, or in [ommbid.mhmedical.com]

[…] hypoketotic hypoglycemia that resolved after treatment with carnitine supplementation. [en.wikipedia.org]

Other symptoms were weakness or acute coma and episodes of fasting hypoglycemia. [advbiores.net]

Islet Cell Tumor

The tumor was surgically removed, relieving the fasting hypoglycemia. [ncbi.nlm.nih.gov]

We report a 22-yr-old male patient with chronic hepatitis B and a large, well differentiated hepatoma who developed episodes of symptomatic fasting hypoglycemia, which were [ncbi.nlm.nih.gov]

Fasting hypoglycemia was believed to be the cause of the movements. A computed tomographic scan showed a large mass in the left inferior hemithorax. [ncbi.nlm.nih.gov]

Pyruvate Carboxylase Deficiency

hypoglycemia. [prep4usmle.com]

Hypoglycemia Hypoglycemia may occur during fasting because of reduced gluconeogenesis. [emedicine.medscape.com]

[…] ques how do you differentiate b/n PC deficiency and PDH deficiency.. young_doc Forum Guru Topics: 59 Posts: 718 Aug 15, 2006 - 7:44 PM #4 PDH deficiency should not give fasting [prep4usmle.com]

Insulin Overdose

Its hallmark presentation is a fasting hypoglycemia because even though the person hasn’t eaten overnight where normally there would be negligible insulin secretion, the insulinoma [arn.org]

A timely noticed attack of hypoglycemia can be stopped by eating foods containing fast carbohydrates - sugar, candy, a sweet drink. [en.intoxication-stop.com]

Hypoglycemia can be caused from taking too much insulin, and you should consume fast-acting carbohydrates as soon as possible before urgently seeking advice from professional [diabetescommunity.com]

Paraneoplastic Syndrome

insulin growth factor 2, non-islet cell tumors, paraneoplastic syndrome, therapy Abstract Paraneoplastic syndrome has a wide range of symptoms and fasting hypoglycemia is [mattioli1885journals.com]

Seen in febrosarcoma, haemangiofibropericytoma, hepatoma)  Diagnosis: fasting hypoglycemia  Plasma insulin/pro-insulin/peptide C during hypoglycemia  Treatment:  Anticancer [slideshare.net]

Clinical features may vary and typical laboratory features of paraneoplastic hypoglycemia includes low level of fasting glucose and C-peptide, low insulin growth factor 1 [mattioli1885journals.com]

Acute Alcohol Intoxication

Norris JFB, Robinson A (1976) Post-alcoholic hypoglycemia in a child. BMJ I: 714 Google Scholar 51. [link.springer.com]

Nuutinen H, Lindros K, Hekali P, Salaspuro M (1985) Elevated blood acetate as indicator of fast ethanol elimination in chronic alcoholics. [link.springer.com]

Chronic Alcoholism

Alcoholic Hypoglycemia & Ketosis Alcoholic hypoglycemia occurs as a result of prolonged fasting and excess alcohol intake, when the hepatic glycogen store becomes depleted [pubs.sciepub.com]

[…] which helps in maintaining blood glucose levels. if these substrates or pathways fail to produce glucose during fasting state it aggravates the risk of hypoglycemia. [pubs.sciepub.com]

Both lipolytic and ketogenic pathways are important to prevent hypoglycemia by providing substrates like glycerol, free fatty acids (FFA), ketone bodies for gluconeogenesis [pubs.sciepub.com]

Addison Disease

Patients with adrenal insufficiency develop hypoglycemia after fasting because of decreased gluconeogenesis. [msdmanuals.com]

[…] when fasting Metabolic acidosis Moderate neutropenia Eosinophilia Relative lymphocytosis Anemia, normochromic, normocytic Follow-Up Tests & Special Considerations Standard [unboundmedicine.com]

In contrast, patients with hypoglycemia due to oversecretion of insulin can have attacks at any time, usually have increased appetite with weight gain, and have normal adrenal [msdmanuals.com]

Panhypopituitarism

Fast heart rate (tachycardia). Vomiting. Diarrhea. Low blood sugar (hypoglycemia). [my.clevelandclinic.org]

Fast heart rate (tachycardia). Excessive thirst and excessive urination. Irregular menstruation (periods). Female infertility. Male infertility. [my.clevelandclinic.org]

Low blood sugar (hypoglycemia). Sensitivity to cold. Unusually dry skin. Unexplained weight loss or weight gain. Irregular lipid and cholesterol levels (dyslipidemia). [my.clevelandclinic.org]

Myxedema

[…] heart, feeling hot, sweating) Administered glucose IV for hypoglycemia Keep patient warm with warming blankets as prescribed NO sedatives or narcotics for these patients… [registerednursern.com]

[…] corticosteroids may be prescribed along with treatment) ****Watch for signs and symptoms of Synthroid toxicity which would present as signs and symptoms of hyperthyroidism (fast [registerednursern.com]

Addisonian Crisis

In this test, blood is drawn to measure the blood glucose and cortisol levels, followed by an injection of fast-acting insulin. [pituitary.org]

Insulin-Induced Hypoglycemia Test A reliable test to determine how the hypothalamus and pituitary and adrenal glands respond to stress is the insulin-induced hypoglycemia [pituitary.org]

Adrenocortical Carcinoma

Fasting or postabsorptive hypoglycemia also can be present in adrenal carcinoma and is dependent primarily on excessive tumor production of “big” insulin‐like growth factor [acsjournals.onlinelibrary.wiley.com]

Pituitary-Adrenal Axis Suppression

The clinical score asks patients for fatigue, hypoglycemia (hypoglycemic symptoms or fasting glucose < 3,5 mmol), loss of energy, orthostatic disturbance or hypotonia (systolic [bmcpulmmed.biomedcentral.com]

Adrenal Gland Disease

In this test, blood is drawn to measure the blood glucose and cortisol levels, followed by an injection of fast-acting insulin. [pituitary.org]

Insulin-Induced Hypoglycemia Test A reliable test to determine how the hypothalamus and pituitary and adrenal glands respond to stress is the insulin-induced hypoglycemia [pituitary.org]

Adrenal Insufficiency Secondary to Hypopituitarism

Because of impaired gluconeogenesis, hypoglycemia may be present particularly with fasting or alcohol ingestion, and hyponatremia is common due to inappropriate secretion [ocw.tufts.edu]

In this test, blood is drawn to measure the blood glucose and cortisol levels, followed by an injection of fast-acting insulin. [pituitary.org]

Hypoglycemia may be found in patients in the fasting state and during adrenal crisis. [glowm.com]

Chlorpropamide

[…] heartbeat, fainting, or seizure (severe hypoglycemia can be fatal). [rxlist.com]

Symptoms of severe hypoglycemia include extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure. [everydayhealth.com]

The most common side effect of Diabinese is low blood sugar ( hypoglycemia ). [rxlist.com]

Hypoglycemia

Fasting hypoglycemia Nesidioblastosis is a rare cause of fasting hypoglycemia in infants and an extremely rare cause in adults. [emedicine.com]

Flash glucose monitoring (FGM) systems revealed glucose profiles with fasting hypoglycemia, which facilitated the clinical diagnosis of insulinoma even though she was unaware [ncbi.nlm.nih.gov]

Hypoglycemia in patients with islet cell adenomas results from uncontrolled insulin secretion, which may be clinically determined during fasting and exercise. [emedicine.com]

Chronic Kidney Insufficiency

Abstract Anemia is a major problem in patients with chronic kidney insufficiency. The development of recombinant human erythropoietin has enabled physicians to correct this anemia. Although anemia has not been considered to be a common or important contributor to congestive heart failure, anemia of any cause can[…] [ncbi.nlm.nih.gov]