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59 Possible Causes for Fatigue, Hepatomegaly, Postural Defect

  • Amyloidosis

    Hepatic involvement is common, but the clinical manifestations are usually mild with hepatomegaly and an elevated alkaline phosphatase level.[ncbi.nlm.nih.gov] Flies carrying mutant variants, but not wild-type TTR, exhibit changes in wing posture, locomotor defects, and shortened life span.[flybase.org] After one year, her symptoms of fatigue became worse, and her proteinuria increased.[ncbi.nlm.nih.gov]

  • Parkinson's Disease

    Neonates with 3-β-hydroxy-C 27 -steroid oxidoreductase deficiency show hepatomegaly, mild steatorrhea, elevated serum ALT and AST, hyperbilirubinemia, and normal serum γ-glutamyl[doi.org] Parkinson's disease (PD) is a neurodegenerative disorder characterized by tremor, rigidity, akinesia, and postural instability ( 1 ).[doi.org] […] interventions for fatigue.[ncbi.nlm.nih.gov]

  • Hyperammonemia Type 3

    A congenital form occurs in two types: Type 1, due to deficiency of the enzyme ornithine carbamoyltransferase, is marked by vomiting, lethargy, coma, and hepatomegaly; symptoms[medical-dictionary.thefreedictionary.com] Above 1000 µmol/L: About 50% survive Ammonia levels seen in inborn errors of metabolism: Urea cycle defects: 500 to 2000 µmol/L Organic acidemia: 100 to 1000 µmol/L Transport[ebmconsult.com] […] syndrome, Chinese restaurant syndrome, Christian syndrome, Christ-Siemens-Touraine syndrome, Chromosome breakage syndrome, Chronic exertional compartment syndrome, Chronic fatigue[acronymattic.com]

  • Homocystinuria

    […] inborn error of metabolism of sulfur amino acids due to lack of the enzyme cystathionine synthase; it is characterized by homocystine in the urine and by mental retardation, hepatomegaly[medical-dictionary.thefreedictionary.com] CONTINUE SCROLLING OR CLICK HERE FOR RELATED ARTICLE Reviewed on 12/12/2018 SLIDESHOW The 14 Most Common Causes of Fatigue See Slideshow[medicinenet.com] Many, if not all, patients have some type of hepatic involvement which may produce mild hepatomegaly with imaging characteristics and/or biopsied pathology of fatty infiltration[cancertherapyadvisor.com]

  • Dysautonomia

    Hepatomegaly, spider nevi, caput medusae, parotid hypertrophy, Dupuytren contracture, and other features of alcoholism may suggest a concurrent ethanol/nutritional neuropathy[emedicine.medscape.com] However, the following have been identified and may be involved: Single gene defects. Accumulation of toxins. Autoantibodies.[patient.info] Fatigue was assessed using the Fatigue Impact Scale (FIS).[dx.doi.org]

  • Mitochondrial Myopathy

    Diabetes mellitus Cardiac arrhythmias Acid maltase deficiency or glycogen storage disorder type 2 Approximately 1 in 40,000 newborns Proximal girdle weakness Macroglossia, hepatomegaly[clevelandclinicmeded.com] She developed generalized posturing in the postoperative period indicative of significant CNS dysfunction.[mhaus.org] During physical activity, muscles may become easily fatigued or weak. Muscle cramping is rare, but may occur.[ninds.nih.gov]

  • Cardiac Asthma

    Typical signs: tachycardia, tachypnoea, pulmonary rales, pleural effusion, raised jugular venous pressure (JVP), peripheral oedema, hepatomegaly.[patient.info] Patients with chronic CHF and orthopnea have a considerable increase in airflow resistance upon adopting the supine posture associated with supine expiratory flow limitation[dx.doi.org] Patients with heart failure report other symptoms that can be similar to patients with poorly controlled asthma including fatigue, weakness, and being more tired.[verywellhealth.com]

  • Acute Pandysautonomia

    The presence of lymphadenopathy, hepatomegaly or splenomegaly, and skin lesions may provide evidence of systemic disease.[aafp.org] However, the following have been identified and may be involved: Single gene defects. Accumulation of toxins. Autoantibodies.[patient.info] We conclude that chronic fatigue syndrome is highly related to orthostatic intolerance in adolescents.[pediatrics.aappublications.org]

  • Urea Cycle Disorder

    […] profile: Elevated plasma citrulline and glutamine, elevated urine argininosuccinate Clinical features: Episodic hyperammonemia, hepatic fibrosis, elevated liver enzymes, hepatomegaly[msdmanuals.com] Diagnosis Often the clinical appearance of urea cycle defects mimics that of other inborn errors of metabolism.[pedclerk.bsd.uchicago.edu] Some results may be fatigue, muscle weakness and diabetes.[sharecare.com]

  • Ataxia

    Consequently, patients may develop splenomegaly and hepatomegaly as well as ataxia.[pn.bmj.com] Cerebellar lesion Signs or Function Posterior (Flocculo-nodular lobe; Archicerebellum) Eye movement disorders: Nystagmus; Vestibulo-ocular reflex (VOR) Postural and gait dysfunction[neuromuscular.wustl.edu] […] loss of balance and coordination, which usually occurs between five to 15 years of age. 5 People with FA experience progressive loss of coordination, muscle weakness, and fatigue[reatapharma.com]

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