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177 Possible Causes for Fatigue, Hepatomegaly, Variable Hypoglycemia

  • Glycogen Storage Disease Type 6

    Individuals with GSD VI typically exhibit hepatomegaly, growth retardation, and variable but mild episodes of fasting hypoglycemia and hyperketosis during early childhood.[emedicine.medscape.com] Hepatomegaly and hypoglycemia are common consequences, although the symptoms are usually mild.[symptoma.com] The inability to release glucose from stored hepatic glycogen results in hypoglycemia and the clinical picture of fatigue, irritability, abnormal sweating, and decelerating[wohproject.org]

  • Diabetes Mellitus

    Associated Complications: CNS : retinopathy, peripheral neuropathies , and autonomic neuropathy (decreased heart rate variability, orthostatic hypotension, gastroparesis,[openanesthesia.org] Abstract Glycogenic hepatopathy is a rare condition that causes significant hepatomegaly and elevated liver enzyme levels in uncontrolled type 1 diabetic patients.[ncbi.nlm.nih.gov] Myasthenia gravis (MG) is an acquired disease of the neuromuscular junctions characterized by muscular weakness and fatigue, with a prevalence of 50-125 cases per million[ncbi.nlm.nih.gov]

  • Cardiomyopathy

    […] present Hypoglycemia Hepatomegaly Cardiomyopathy Lab Fasting ketogenesis: Low Diagnostic testing Organic acids Normal with random testing or during myalgic episode Hypoketotic[neuromuscular.wustl.edu] These signs and symptoms include: Shortness of breath or trouble breathing, especially with physical exertion Fatigue (tiredness) Swelling in the ankles, feet, legs, abdomen[web.archive.org] Symptoms: Patients with cardiomyopathy will typically present with dyspnea, orthopnea, paroxysmal nocturnal dyspnea, bilateral edema, and fatigue.[symptoma.com]

  • Diabetes Mellitus Type 1

    There was no significant between-group difference in the number of severe hypoglycemia events. (p 0.1276).[ncbi.nlm.nih.gov] Hepatomegaly and elevated liver enzymes in patients with diabetes are commonly associated with fatty liver disease.[ncbi.nlm.nih.gov] Patients experience the following: Increased thirst Increased hunger Increased urination Fatigue Blurry vision Rapid weight loss in a short amount of time Hunger Neurologic[symptoma.com]

  • Acute Lymphoblastic Leukemia Type L1

    . : Hypoglycemia and glycemic variability among children with acute lymphoblastic leukemia during maintenance therapy. Leuk Lymphoma. 2011; 52 (9): 1704–10.[f1000research.com] RESULTS: Among 130 children receiving PEG-asparaginase biweekly, 29 developed SOS ( 2 criteria: hyperbilirubinemia, hepatomegaly, ascites, weight gain 2.5%, unexplained thrombocytopenia[ncbi.nlm.nih.gov] CONCLUSION: Neurocognitive function in female survivors of childhood ALL appears more susceptible to the effects of sleep disturbance and fatigue.[ncbi.nlm.nih.gov]

  • Glycogen Storage Disease Type 1

    1 The variable clinical phenotype of three patients with hepatic glycogen synthase deficiency. ( 28245189 ) 2017 2 Pediatric patient with hyperketotic hypoglycemia diagnosed[malacards.org] The syndrome results in hepatomegaly secondary to glycogen accumulation, glucose and galactose intolerance, fasting hypoglycaemia, a characteristic proximal tubular nephropathy[en.wikipedia.org] The low levels of glucose in the blood of these individuals often result in chronic hunger, fatigue, and irritability.[liverfoundation.org]

  • Nephroblastoma

    Variable complications of BWS include organomegaly, hypoglycemia, hemihypertrophy, genitourinary abnormalities, and, in about 5% of children embrional tumors.[termedia.pl] VOD is primarily a clinical diagnosis characterized by hepatomegaly or pain in the right upper quadrant, jaundice, ascites, and unexplained weight gain.[emedicine.medscape.com] […] a pediatrician during a routine check-up, although it may be accompanied by symptoms such as blood in the urine, anemia (which may be accompanied by unusual bleeding or fatigue[columbiadoctors.org]

  • Acute Fatty Liver of Pregnancy

    The laboratory results indicated coagulopathy, liver function abnormalities and hypoglycemia. Emergency cesarean section was performed in two cases.[ncbi.nlm.nih.gov] USG abdomen revealed hepatomegaly with fatty changes grade 2-3, medical renal disease, and minimal ascites.[najms.org] Case 3 developed loss of appetite and general fatigue with jaundice 10 days before delivery. They underwent termination of pregnancy after diagnosis was made.[ncbi.nlm.nih.gov]

  • Glycogen Storage Disease Type 2

    1 The variable clinical phenotype of three patients with hepatic glycogen synthase deficiency. ( 28245189 ) 2017 2 Pediatric patient with hyperketotic hypoglycemia diagnosed[malacards.org] Patients have also organomegaly (hepatomegaly, splenomegaly, macroglossia) and feeding difficulties.[ncbi.nlm.nih.gov] Disorder or Manic Depression, Panic Disorder, schizophrenia, autism, head trauma, memory loss, low iq, mental retardation, learning disability, epilepsy, cancer, chronic fatigue[disability-claims.net]

  • Medium Chain Acyl CoA Dehydrogenase Deficiency

    These include hypoketotic hypoglycemia, hypotonia, lethargy, and vomiting.[nature.com] When, inadvertently he was given medium-chain triglycerides for 2 days, the excretion of abnormal metabolites of medium-chain fatty acids increased and hepatomegaly became[ncbi.nlm.nih.gov] On follow-up, a total of 44 patients reported fatigue (35%; 28/80), muscle pain (31%; 25/80), and/or reduced exercise tolerance (39%; 31/80).[ncbi.nlm.nih.gov]

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