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779 Possible Causes for Fatigue, HLA-B27

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  • Influenza

    Abstract An 88-year-old woman presented to our emergency room with complaints of fever, coryza, barking cough and generalised fatigue for 2 days.[ncbi.nlm.nih.gov] Structural homologies between two HLA B27-restricted peptides suggest residues important for interaction with HLA B27. Int Immunol 2 : 311 –6. Hughes AL, Nei M. 1988 .[dx.doi.org] Infected individuals usually experience a rapid onset of flu symptoms which typically include: muscle aches, high fever, head ache, chills, fatigue, dry cough and runny/stuffy[3dscience.com]

  • Ankylosing Spondylitis

    GETTY Ankylosing spondylitis: Symptoms include fatigue Ankylosing spondylitis causes back pain, stiffness and fatigue A total of five factors were identified as independent[express.co.uk] In literature, although the evidence for association between AS and periodontitis as well as AS and HLA-B27 are there but the association of aggressive periodontitis in HLA-B27[ncbi.nlm.nih.gov] KEYWORDS: Ankylosing spondylitis; HLA-B27; Klebsiella pneumoniae[ncbi.nlm.nih.gov]

  • Enthesitis-Related Arthritis

    We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: January 30, 2019[patientslikeme.com] […] method permitted identification of common HLA-B27 subtypes (HLA-B*27:01 to HLA-B*27:09).[ncbi.nlm.nih.gov] When the disease is active, up to 10% of patients will develop systemic manifestations such as fever, weight loss, fatigue, muscle weakness, muscle atrophy, and lymphadenopathy[symptoma.com]

  • Crohn's Disease

    Abstract A 53-year-old man with Crohn's disease treated with adalimumab was hospitalised with abdominal pain, fatigue, fever and chills.[ncbi.nlm.nih.gov] However, they have only a transient benefit in HLA-B27 transgenic rats[ 24 ].[doi.org] The symptoms of the non-IBS prodrome in subjects with Crohn's disease were bloating, diarrhea, stomach pain, heartburn, fever, weight loss, and fatigue.[ncbi.nlm.nih.gov]

  • Spondylitis

    "This can make you excessively fatigued.”[everydayhealth.com] Many HLA-B27 positive don’t get AS, and some people without it do. Prevalence 2-8% (30% in eskimos!)[oxfordmedicaleducation.com] GETTY Ankylosing spondylitis: Symptoms include fatigue Ankylosing spondylitis causes back pain, stiffness and fatigue A total of five factors were identified as independent[express.co.uk]

  • Juvenile Seronegative Polyarthritis

    It also can make you feel fatigued or lose your appetite. You might run a mild fever. In severe cases, it can make your spine stiffer.[webmd.com] The HLA B27-positive patients contracted amyloidosis on average 5.9 (median 6.7) years earlier than the HLA B27-negative patients ( p 0.038).[link.springer.com] Apart from joint involvement there are symptoms like irritability, fatigue, anemia, loss of appetite, growth retardation etc.[news-medical.net]

  • Whipple Disease

    Abstract A 72-year-old man presented with a 6-month history of dysphagia, fatigue, 60-lb weight loss, and central nervous system (CNS) deficits.[ncbi.nlm.nih.gov] About 30% of patients have HLA-B27. Drugs Mentioned In This Article PLAQUENIL No US brand name ROCEPHIN PERIOSTAT, VIBRAMYCIN[merckmanuals.com] His recent symptoms included persistent fatigue, weight loss, fever, and arthralgias.[ncbi.nlm.nih.gov]

  • Psoriatic Arthritis

    The causes of this debilitating fatigue are multifaceted; coexisting conditions such as fibromyalgia or depression can be one of them, as they arouse fatigue in many cases[psoriasis.qualitycarebyleo.com] While a number of genes are linked to PsA, the highest predictive value is noted with HLA-B27.[spondylitis.org] Psoriatic Arthritis Quality of Life (PsAQoL) Scale was used to assess the quality of life, Multidimensional Assessment of Fatigue (MAF) Scale was used to evaluate fatigue,[ncbi.nlm.nih.gov]

  • Juvenile Onset Stills Disease

    Children, who develop JRA often experience fatigue, stiffness, and some joint pain.[dovemed.com] Absence of psoriasis and other autoimmune diseases with positive HLA-B27 mutations, such as ankylosing spondylitis, Reiter's syndrome or sacroilitis with inflammatory bowel[symptoma.com] Extreme fatigue can accompany waves of high fevers that rise daily to 102 F (39 C) or even higher and rapidly return to normal levels or below.[medicinenet.com]

  • Juvenile Ankylosing Spondylitis

    Fatigue was reported by 98% of patients with autoimmune disorders polled, and fatigue that prevented completion of everyday tasks was reported by 68% of the patients, according[healio.com] Nine of the 10 patients exhibited the genetic marker HLA B27, but only one patient was homozygous for HLA B27.[ncbi.nlm.nih.gov] HLA-B27 was found in 4 out of 6 cases. This frequency is almost equal to that of adult ankylosing spondylitis patients.[ncbi.nlm.nih.gov]

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