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302 Possible Causes for Fatigue, Hypercellular Bone Marrow

  • Leukemia

    Evidence-based treatment for cancer-related fatigue. J Natl Cancer Inst Monogr. 2004 ;32: 112 - 118.[doi.org] Bone marrow aspirate showed hypercellularity with increased myelopoiesis and markedly suppressed megakaryopoiesis giving an impression of acute myeloid leukemia and was confirmed[ncbi.nlm.nih.gov] Another important feature of bone marrow samples is its cellularity. Normal bone marrow contains hematopoietic (blood-forming) cells and fat cells.[web.archive.org]

  • Paroxysmal Nocturnal Hemoglobinuria

    By using the Functional Assessment of Chronic Illness Therapy Fatigue instrument (scores can range from 0 to 52, with higher scores indicating improvement in fatigue), the[ncbi.nlm.nih.gov] These patients tend to have a normocellular to hypercellular bone marrow with erythroid hyperplasia, an elevated reticulocyte count, a large population of PNH cells (usually[doi.org] Furthermore, the patient showed significant improvements in fatigue scale scores and quality of life.[ncbi.nlm.nih.gov]

  • Myeloproliferative Disease

    We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: January 30, 2019[patientslikeme.com] Bone marrow histology shows hypercellularity in most of these disorders. In the case of myelofibrosis, bone marrow fibrosis is demonstrated on the reticulin stain.[emedicine.com] Splenomegaly, hepatomegaly as well as fatigue, malaise or weight loss may appear in advanced stages.[orpha.net]

  • Chronic Myeloid Leukemia

    Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly.[icd9data.com] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] On initial presentation she reported fatigue, night sweats, and early satiety, and was found to have a white blood cell (WBC) count of 69.3 109 /L and platelet count of 366[ncbi.nlm.nih.gov]

  • Autoimmune Hemolytic Anemia

    Subsequently, he was admitted to our hospital owing to fatigue, a high fever, and jaundice.[ncbi.nlm.nih.gov] Subsequently, the patient underwent a bone marrow biopsy that showed a hypercellular marrow with erythroid hyperplasia, but no evidence of dysplasia or lymphoma.[doi.org] A 12-year-old male child presented to the emergency room with three days history of cola-colored urine, mild icterus, dyspnea, palpitation and fatigue.[ncbi.nlm.nih.gov]

  • Polycythemia Vera

    79.5%) patients experienced momelotinib-related adverse events (AEs), the most frequent being headache (23.1%), dizziness (18.0%), somnolence (15.4%), nausea (15.4%), and fatigue[ncbi.nlm.nih.gov] bone marrow 5.[slideshare.net] Regardless of baseline iron status, treatment with ruxolitinib was associated with improvements in concentration problems, cognitive function, dizziness, fatigue, headaches[ncbi.nlm.nih.gov]

  • Chronic Phase of Chronic Myeloid Leukemia

    In the accelerated phase, the number of CML cells is growing faster and causing symptoms such as fatigue, fever, weight loss and an enlarged spleen.[lls.org] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] People in this phase may notice symptoms like fatigue, caused by a lower number of red blood cells, and stomach pain due to an enlarged spleen.[healthline.com]

  • Acute Leukemia

    The initial manifestations of leukemia are generally signs of bone marrow failure, such as pallor, fatigue, fever, bleeding, and infection related to peripheral blood cytopenias[ncbi.nlm.nih.gov] ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[pathologyoutlines.com] A 54-year-old Chinese male patient who complained of chest pain and fatigue for 20 days. Bone marrow aspirate examination revealed hypercellularity with 70% blast cells.[ncbi.nlm.nih.gov]

  • Cooley's Anemia

    Thalassemia intermedia cause symptoms of moderate to severe anemia including: Fatigue, Paleness, Slow or delayed growth, Weak bones, Enlarged spleen.[omicsonline.org] Fatigue and being short of breath are two of the more common symptoms. The individual is also likely to be somewhat pale, possibly exhibiting signs of jaundice .[wisegeek.com] Fatigue and being short of breath are two of the more common symptoms. The individual is also likely to be somewhat pale, possibly exhibiting signs of jaundice.[wisegeek.com]

  • Ayerza Syndrome

    N Engl J Med 1941; 225:845-855 MILITARY SYMPOSIUM FATIGUE IN AIRCRAFT PILOTS* Ross A. McFarland, PH.D.[nejm.org] NEWS.com.au Top Stories In particular, fatigue does not improve, possibly due to co-existing medical problems, such as obstructive sleep apnea or obesity hypoventilation,[wordnik.com] \s d\ BOSTON ONE of the most significant problems in civil and military aviation relates to what is popularly known as "pilot fatigue."[nejm.org]

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