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123 Possible Causes for Fatigue, Hypersegmented Neutrophils, Leukemia

  • Myelodysplasia

    Dysplasia in the myeloid series is defined by: Granulocytic series Hypersegmented neutrophils (also seen in Vit B12/Folate deficiency) Hyposegmented neutrophils (Pseudo-Pelger[] Therapy-related leukemia (myelodysplasia and acute myeloid leukemia-t-MDS/AML) is a well-known complication of conventional chemoradiotherapy used to treat a variety of primary[] He required a wheelchair for community mobility because of complaints of fatigue and upper extremity discomfort.[]

  • Thrombotic Thrombocytopenic Purpura

    Due to the presence of macroovalocytes and hypersegmented neutrophils, vitamin B12 level was checked and found to be extremely low.[] We report a female patient presenting with headache, fatigue, ecchymoses and recent, excessive vaginal bleeding.[] To our knowledge, thrombotic microangiopathy has been reported as a side effect of interferon (IFN) use in patients with hepatitis and chronic myeloid leukemia, but not in[]

  • Leukopenia

    neutrophils Acute leukemia, chronic myelogenous leukemia Bone marrow replacement with malignant cells Pancytopenia, leukocytosis Myelodysplasia Dysplastic maturation of stem[] A 41-year-old man sought treatment for cutaneous and bone marrow sarcoidosis resulting in fatigue, anemia, and leukopenia refractory to conventional therapies and mycophenolate[] The microgranular variant (M3v) of acute promyelocytic leukemia (APL) is rare, and the diagnosis can be delayed due to variability in how this condition presents.[]

  • Anemia

    The peripheral smear can also be useful for identifying megaloblasts (large, dysfunctional and immature RBCs), or hypersegmented neutrophils which are both seen in megaloblastic[] The most common symptoms of anemia are fatigue and an inability to focus. Gradually, one’s performance begins to decline and judgments become impaired.[] Additionally, eMX2 inhibits HIV-1 and other lentiviruses, including murine leukemia virus.[]

  • Pancytopenia

    The blood smear (Panel A) shows macroovalocytes (arrowheads) and hypersegmented neutrophils (arrow).[] We report a case of recurrent pancytopenia resulting from maintenance chemotherapy in a patient with acute promyelocytic leukemia and two pharmacogenetic mutations, namely[] In addition to fatigue and easy bruising, the patient reports a history of unexplained lower extremity swelling and recurrent herpes infections.[]

  • Diamond-Blackfan Anemia

    neutrophils, normal B9, B12, no evidence of parvovirus B19 infection) Elevated ADA Elevated hemoglobin F DBS: Double Blood cell Size - Macrocytic anemia.[] Patients with DBA present with fatigue, sleepiness or pallor.[] Such a karyotype evolution has been described in some cases of acute leukemia associated with Down Syndrome, but rarely in non-Down cases.[]

  • Hepatosplenomegaly

    The peripheral blood smear contained oval macrocytes, hypersegmented neutrophils, trombocytopenia, leucopenia and low reticulocyte count.[] […] is common at diagnosis of pediatric leukemia and is diagnosed through palpation or ultrasound.[] We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: November 30, 2018[]

  • Thrombocytosis

    Complete blood count (CBC) and peripheral blood smear examination revealed a leukocytosis (35000/μl) and a considerable number of hypersegmented neutrophil ( 6% with more[] I am 59 also, and do have fatigue now and I have to agree it does wreak havoc on your life and chang your daily activities.[] A patient with acute monocytic leukemia presented with spurious thrombocytosis.[]

  • Vitamin B12 Deficiency

    neutrophils (type of white blood cells) Leukopenia (low white blood cell count) Thrombocytopenia (low blood platelet count) Glossitis Hyperpigmentation of the skin Vomiting[] Chronic myelogenous leukemia, promyelocytic leukemia, polycythemia vera and hypereosinophilic syndrome have all been associated with high B12 levels ( 25 ).[] The clinical symptoms are weakness, fatigue, shortness of breath and neurologic abnormalities.[]

  • Hypoalbuminemia

    neutrophil Döhle bodies Pelger–Huet anomaly Small molecules Blood sugar Hypoglycemia Hyperglycemia Prediabetes Impaired fasting glucose Impaired glucose tolerance Oxyhyperglycemia[] You may have swelling that is all over your body, or swelling in one part of your body (such as your legs) You may have muscle weakness , fatigue, or cramps You may have a[] This single-center retrospective study included adult patients with leukemia or lymphoma who received their first MTX at a dose 1 g/m2.[]

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