Fatigue & Intermittent Slow Activity & Parkinson's Disease: Causes & Reasons

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Fatigue, Intermittent Slow Activity, Parkinson's Disease,

Negated

None

Unsure

None

Possible Causes

Alzheimer Disease

Its application is costly in terms of the time employed, with all the negative consequences this entails (decrease in motivation, frustration, and fatigue). [ncbi.nlm.nih.gov]

Parkinson's Disease Rating Scale; MMSE: Mini-Mental State Examination; PD: Parkinson disease; PDD: Parkinson disease dementia. [ncbi.nlm.nih.gov]

Monitor personal comfort: check for pain, hunger, thirst, constipation, full bladder, fatigue, infections, and skin irritation; ensure a comfortable temperature; be sensitive [web.archive.org]

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Stroke

Generalized or regional bisynchronous slow activity - Generalized or regional bisynchronous slow activity may be intermittent or continuous, and seems to be due to disordered [scielo.br]

He had 3 months history of fatigue, fever, and weight loss. Neurological examination revealed left hemiparesis and dysarthria. [ncbi.nlm.nih.gov]

Cerebral glucose metabolism and cognition in newly diagnosed Parkinson's disease: ICICLE-PD study, A J Yarnall, R A Lawson, G W Duncan, T K Khoo, G S Petrides, J T O'Brien [jnnp.bmj.com]

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Dementia

Difficulty in concentrating, fatigue, and sleep disturbance do not. 17 No studies to date have examined anxiety disorders other than GAD in this population. [web.archive.org]

To determine which clinical features best characterize Parkinson disease dementia (PDD), compared with Alzheimer disease (AD) and dementia with Lewy bodies (DLB), and to determine [ncbi.nlm.nih.gov]

Difficulty swallowing, bowel problems such as constipation and diarrhoea, fatigue, memory loss – all of these can be combatted to varying extents with careful nutrition. [telegraph.co.uk]

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Traumatic Brain Injury

We believe that these injuries of the ARAS might be a pathogenetic mechanism of fatigue and hypersomnia in patients with TBI. [ncbi.nlm.nih.gov]

TBI has also been implicated in the development of Parkinson disease, increasing the likelihood that patients may be treated with dopaminergic agents. [ncbi.nlm.nih.gov]

Increasing evidence indicates that TBI is an important risk factor for neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and chronic traumatic [ncbi.nlm.nih.gov]

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Hyponatremia

Our patient complained of left knee pain, fatigue, and bilateral lower limb cramps. [ncbi.nlm.nih.gov]

Dementia has many risk factors[ 22 ], including age, sex, DM, hypertension, hyperlipidemia, atrial fibrillation, coronary artery diseases, mental illness, and Parkinson’s [journals.plos.org]

A 52-year-old Sri Lankan man presented with anorexia, nausea, fatigue, generalized muscle weakness, and cramps for 1 week. [ncbi.nlm.nih.gov]

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Encephalitis

Symptoms include headache, fever, confusion, drowsiness, and fatigue. [commons.wikimedia.org]

disease), diuretics, tricyclic or tetracyclic antidepressants and benzodiazepines. [en.wikipedia.org]

Are you sad, bored, fatigued, irritable, unable to concentrate, pessimistic? If you've been feeling this way for at least 2 weeks, you may have clinical depression. [web.archive.org]

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Creutzfeldt Jakob Disease

These include periodic lateralising epileptiform discharges in encephalitis, frontal intermittent delta activity in toxic–metabolic or structural abnormalities (if asymmetrical [doi.org]

He had sleep problems and then lots of fatigue over a 2-yr. period, but we both thought that it was the inability to sleep soundly and age. [globalgenes.org]

Jellinger KA (2000) Cell death mechanisms in Parkinson’s disease. J Neural Transm 107:1–29 PubMed CrossRef Google Scholar 32. [oadoi.org]

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Encephalitis Lethargica

Electroencephalogram showed slow and asymmetric background activity which was more obvious over right hemisphere. [hkjpaed.org]

Descriptions of lethargy are explored as a way of elucidating concepts of sleep, fatigue, and motivation during the study period. [ncbi.nlm.nih.gov]

Parkinson's Disease is a neurological disorder caused by the lack of dopamine in the brain. [awakenings-brain-bloodbrainbarrier.weebly.com]

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Hydrocephalus

He reported a 10-day history of fever, photophobia, headache and fatigue. His medical history included hypothyroidism and migraine. [ncbi.nlm.nih.gov]

Normal pressure hydrocephalus (NPH) is sometimes difficult to diagnosis because its symptoms are similar to other diseases such as Alzheimer's disease and Parkinson's disease [my.clevelandclinic.org]

Irritability, fatigue, seizures, and personality changes such as an inability to concentrate or remember things may also develop. [medicinenet.com]

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Hypersomnia

Electroencephalographic (EEG) background activity for this individual was slightly slowed in the EEG during an episode of hypersomnia, and intermittent slow activity was found [ncbi.nlm.nih.gov]

Symptoms of hypersomnia Aside from extreme fatigue, there are other symptoms of hypersomnia to be aware of. [belmarrahealth.com]

KEYWORDS: Alzheimer disease; Excessive daytime sleepiness; Hypersomnia; Hypersomnolence; Multiple system atrophy; Neurodegenerative diseases; Parkinson disease; Progressive [ncbi.nlm.nih.gov]

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Paroxysmal Exertion-Induced Dyskinesia

Resembles low-amplitude activity of adult REM sleep Decreases from 50% to 30% of total sleep Non-REM SLEEP: Generalized (posterior predominance) delta slow waves Intermittent [quizlet.com]

The dystonic movements are usually bilateral and are aggravated by cold, psychological stress, fatigue and lack of sleep. [orpha.net]

Wood, Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers, Brain, 137, 9, (2480), (2014). [doi.org]

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Toxic Encephalopathy

In the cases of encephalopathy, EEG can register generalized slowing or suppression of the EEG reactivity, loss of fast rhythm with occurrence of diffuse slow activity (theta [neurologyindia.com]

The level of anxiousness and fatigue before a training session decreased during the training period. [ncbi.nlm.nih.gov]

–more… PARKINSON’S Parkinson disease Scientists Identify Neuroprotective Agents for Parkinson’s Disease — more… ADD/ADHD The effect of phosphatidylserine containing Omega3 [national-toxic-encephalopathy-foundation.org]

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Fibromyalgia

[…] temporal focal θ slowing and excessive β. [ncbi.nlm.nih.gov]

Capuron L, Welberg L, Heim C, et al: Cognitive dysfunction relates to subjective report of mental fatigue in patients with chronic fatigue syndrome. [dx.doi.org]

Parkinson's disease (PD) is characterized by motor disturbances such as tremor, slow movement and rigidity. Also, pain is a common symptom in patients with PD. [ncbi.nlm.nih.gov]

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Narcolepsy

Electroencephalography performed while the patient was awake showed frontal intermittent delta activity, a slow alpha rhythm, and excessive theta activity. [jamanetwork.com]

The majority of participants reported residual daytime fatigue and/or sleepiness despite treatment. [ncbi.nlm.nih.gov]

Although amphetamine drugs can damage dopaminergic axons, it is unknown whether chronic treatment with amphetamine increases the risk of developing Parkinson's disease (PD [ncbi.nlm.nih.gov]

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Migraine

Abstract Acute confusional migraine (ACM) shows typical electroencephalography (EEG) patterns of diffuse delta slowing and frontal intermittent rhythmic delta activity (FIRDA [ncbi.nlm.nih.gov]

Adverse events included paresthesia, fatigue, nausea, and anorexia. [aafp.org]

Author information 1 Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA. 2 Department of Neurology [ncbi.nlm.nih.gov]

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Atrial Fibrillation

[…] spike (every two or three beats) in 3, and dissociation from atrial activity as a slow automatic rhythm in 2 ( Figure 4 ). [oadoi.org]

Atrial fibrillation, known as AF or Afib, is an irregular, rapid heart rate that may cause symptoms like heart palpitations, fatigue, and shortness of breath. [medtronic.com]

The researchers found that the strongest predictors for dementia were lack of oral anticoagulant treatment, aging, Parkinson's disease and alcohol abuse. [sciencedaily.com]

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Whiplash Injury

An active therapy program that allows for spinal manipulation or mobilization can help reset the normal positioning of muscles and joints. [brain-injury-law-center.com]

MAIN OUTCOME MEASURE(S): QTF grade, time to muscle fatigue in seconds. [ncbi.nlm.nih.gov]

’s disease, and depression. (6) The majority of people who experience concussion will experience a full recovery. [blog.migrainepal.com]

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Myoclonic Jerking

The interictal EEG showed frequent intermittent generalized theta slowing, but no clear-cut epileptiform activity. [frontiersin.org]

Side effects include nausea, fatigue, and feeling dizzy. Botox injections: The botulinum toxin "freezes" your muscles and keeps them from twitching. [webmd.com]

While medications can be helpful in easing severe symptoms of myoclonus, side effects such as sleepiness, dizziness, fatigue, and unsteadiness may occur. [healthline.com]

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Uremic Encephalopathy

[…] uremic encephalopathy cerebral symptoms seen in patients with uremia, including lethargy, fatigue, inattentiveness, irritability, confusion, sensory disturbances, and sometimes [medicine.academic.ru]

’s Disease Clinic and Research Center, a National Parkinson Foundation Center of Excellence. [books.google.com]

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Severe Depressive Episode

[…] early morning awakening; 2) reduced non-rapid eye movement (NREM) stages 3 and 4 sleep (slow-wave sleep), with a shift in slow-wave activity away from the first NREM period [health.am]

A depression was understood as an unnatural fatigue resulting from an uneconomic hyperarousal of the vegetative nervous system and the dysfunction of the metabolic system [books.google.com]

(National Institute of Mental Health, 2002) Parkinson's Disease: 50% of Parkinson's disease patients may experience depression. [dbsalliance.org]

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Generalized Tonic-Clonic Seizure

If slow spike-and-wave ( 2.5 Hz) is not seen, consider other epilepsy syndromes. Activation. An intermittent photoparoxysmal response to photic stimulation may be seen. [medlink.com]

Sleep deprivation, fatigue and alcohol lower threshold for seizures. [epilepsydiagnosis.org]

The following medical conditions can also lead to dementia: Huntington disease Brain injury Multiple sclerosis Infections such as HIV/ AIDS, syphilis, and Lyme disease Parkinson [mclarenhealthplan.org]

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Progressive Supranuclear Palsy

On examination, she had vertical upgaze palsy and downgaze slowing, intermittent myoclonic jerks of the hand and mild symmetrical bradykinesia with axial rigidity. [doi.org]

So when is fatigue something to be concerned about? [emedicinehealth.com]

P/M, pons to midbrain ratio; PD, idiopathic Parkinson's disease; PSP-RS, Progressive Supranuclear Palsy-Richardson's Syndrome; Parkinson's disease; Progressive Supranuclear [ncbi.nlm.nih.gov]

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Metabolic Encephalopathy

Some Lyme patients do develop fatigue and have trouble thinking straight. [sites.google.com]

Predisposing factors include brain disorders (eg, dementia, stroke, Parkinson disease ), advanced age, sensory impairment (eg, impaired vision or hearing), alcohol intoxication [merckmanuals.com]

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Meningoencephalitis

In infants suffering from ME, clinical presentation includes lack of appetite, fatigue, irritability and fever. [symptoma.com]

Elizan TSCasals J Astrogliosis in von Economo's and postencephalitic Parkinson's diseases supports probable viral etiology. J Neurol Sci. 1991;105:131-134. [jamanetwork.com]

Profound fatigue persisted, but consciousness level normalised and cranial nerve palsies partly resolved. [thelancet.com]

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Wernicke Encephalopathy

One month before this visit, he was noted to have poor appetite and progressive fatigue. [ncbi.nlm.nih.gov]

Parkinson’s, and other debilitating brain disorders that strike adults. [caregiver.org]

The patient developed general fatigue and appetite loss, and his symptoms were gradually aggravated by depression. [ncbi.nlm.nih.gov]

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Extrapyramidal Disorder

66.  Slow 2-3Hz rhythmic alternating movement resemble tremor  Wide spread involvement, may involved multiple body parts  Absent during sleep  May be intermittent or [slideshare.net]

PARKINSON’s DISEASE : PARKINSON’s DISEASE A common idiopathic neurological disease of the elderly characterized by : Brady-hypokinesia, Rigidity Rest tremor PARKINSON’s DISEASE [authorstream.com]

Dystonic spasms increase in intensity during stress, emotional upset, or fatigue. Pharmacologic treatment. Chemodenervation with botulinum toxin injections. [pocketdentistry.com]

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Uremia

However, electroencephalographic (EEG) findings such as slowing or loss of alpha frequency waves, disorganized signals, slow background activity with intermittent bursts of [ncbi.nlm.nih.gov]

Uremia Other names Uraemia Uremic frost present on the forehead and scalp of a young man who presented with complaints of anorexia and fatigue, with blood urea nitrogen and [en.wikipedia.org]

Lundborg noted that the clinical picture of some of his patients in the terminal phase reminded him of Parkinson disease. [medlink.com]

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Anti-NMDA Receptor Encephalitis

[…] or intermittent rhythmic delta activity on EEG, and some subcortical MRI abnormalities). [doi.org]

[…] interquartile range 2.12-3.32) and adults (3.55 years, interquartile range 2.08-5.50 years). 3/4 (75%) pediatric and 3/5 (60%) adult patients reported neuropsychiatric symptoms (fatigue [ncbi.nlm.nih.gov]

Disease: Symposium on Levodopa in Parkinsons Disease 71,12,Suppl.1 2008/09 von: American Academy of Neurology: Resource guide and membership directory Standardnummern ISSN [zdb-katalog.de]

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Propionic Acidemia

N Engl J Med 292: 491496 16 Walk D et al. (1994) Intermittent encephalopathy, reversible nerve conduction slowing, and MRI evidence of cerebral white matter disease in methylene-tetrahydrofolate [vdocuments.us]

We present a previously healthy teenager, who suffered from acute fatigue and breathlessness. [ncbi.nlm.nih.gov]

Disease Completed NCT00407212 Phase 1, Phase 2 TCH346 (dibenz[b,f]oxepin-10-ylmethyl-prop-2-ynyl-amine, hydrogen maleate salt) 11 Oral Propranolol Versus Placebo for Early [malacards.org]

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Bradyarrhythmia

[…] or conduction that result in slow or irregular heart rates or intermittent tachycardia. [slideplayer.com]

When your heart rhythm is too slow, this can cause dizziness, fatigue, feelings of lightheadedness, fainting or near-fainting spells. [uwhealth.org]

’s Disease Challenge Yourself Interactive Medical Cases Image Challenge Videos in Clinical Medicine View all learning/CME Other NEJM Group Learning Hand Hygiene Essential [nejm.org]

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