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233 Possible Causes for Fatigue, Massive Splenomegaly, Pancytopenia

  • Primary Myelofibrosis

    She also underwent splenectomy when she was 13 years old, due to massive splenomegaly, anemia and various infection disease episodes.[ncbi.nlm.nih.gov] The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[ncbi.nlm.nih.gov] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com]

  • Paroxysmal Nocturnal Hemoglobinuria

    We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly.[ncbi.nlm.nih.gov] Functional Assessment of Chronic Illness Therapy‐Fatigue (FACIT‐Fatigue).[doi.org] We report a 19-year-old female patient admitted to the hospital with pancytopenia. Workout of pancytopenia disclosed paroxysmal nocturnal hemoglobinuria.[ncbi.nlm.nih.gov]

  • Leukemia

    Splenomegaly can be massive, consistency high, with the fibrous thickening of the capsule.[ncbi.nlm.nih.gov] Evidence-based treatment for cancer-related fatigue. J Natl Cancer Inst Monogr. 2004 ;32: 112 - 118.[doi.org] This fact sheet discusses the theory that intermittent fasting may reduce the risk of cancer or improve outcomes with anticancer treatments. more » A 47-Year-Old Woman with Pancytopenia[cancertherapyadvisor.com]

  • Chronic Lymphocytic Leukemia

    splenomegaly and occasionally lymphadenopathy; prognosis is often poor.[medical-dictionary.thefreedictionary.com] Symptoms of CLL may include: Abnormal bruising (if platelets are low) Enlarged lymph nodes, liver, or spleen Excessive sweating, night sweats Fatigue Fever Infections that[nlm.nih.gov] Brentuximab vedotin had a transient effect, but the patient died of sepsis due to residual PTCL and pancytopenia.[ncbi.nlm.nih.gov]

  • Hairy Cell Leukemia

    Also these cytokines may play a role in the development of hairy cell leukemia.Key words: hairy cell leukemia -  sarcoidosis - massive splenomegaly.[ncbi.nlm.nih.gov] During interferon-α therapy she developed multiple subcutaneous swellings, accompanied by fever and fatigue.[ncbi.nlm.nih.gov] During the preoperative evaluation, pancytopenia was detected.[ncbi.nlm.nih.gov]

  • Myeloproliferative Disease

    Splenomegaly, sometimes massive, is a characteristic finding. Symptoms include the following: Splenic pain. Early satiety. Anemia. Bone pain. Fatigue. Fever.[northshore.org] Splenomegaly, hepatomegaly as well as fatigue, malaise or weight loss may appear in advanced stages.[orpha.net] Four years later, at the age of 16, her brother was diagnosed as having acute myelofibrosis, and some months afterwards he died from fulminant pneumonia coincidently with pancytopenia[ncbi.nlm.nih.gov]

  • Chronic Myeloid Leukemia

    Here, we report a case of aCMLin a 5-month baby who presented with massive splenomegaly. The diagnosis was in accordance with the WHO criteria established in 2008.[ncbi.nlm.nih.gov] Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly.[icd9data.com] We present a case of 29-year-old white male farmer, with chronic myeloid leukemia treated with imatinib who developed significant pancytopenia, leading to discontinuation[ncbi.nlm.nih.gov]

  • Mantle Cell Lymphoma

    Splenomegaly is often massive, while aberrant WBC count may be seen, either as markedly high leukocytosis or pancytopenia.[symptoma.com] The regimen's toxicity profile was acceptable; only 25% of the cycles resulted in grade 3 or 4 neutropenia or thrombocytopenia, and only 3% of cycles produced grade 3-4 fatigue[ncbi.nlm.nih.gov] A 64-year-old male initially presented with fatigue, splenomegaly, and bicytopenia. The bone marrow biopsy specimen revealed extensive infiltration with MCL.[ncbi.nlm.nih.gov]

  • Philadelphia Chromosome Positive Chronic Myeloid Leukemia

    […] included thrombocytopenia (n 8), diarrhea (n 3), alanine aminotransferase elevation (n 3), aspartate aminotransferase elevation (n 2), dyspnea (n 2), neutropenia (n 2), pancytopenia[bloodjournal.org] At this time, they either have no symptoms or vague ones such as fatigue.[symptoma.com] Manifestations include dyspnea, fatigue, hypoxia, and fluid retention. PAH may be reversible on discontinuation of SPRYCEL.[news.bms.com]

  • Chronic Phase of Chronic Myeloid Leukemia

    In the accelerated phase, the number of CML cells is growing faster and causing symptoms such as fatigue, fever, weight loss and an enlarged spleen.[lls.org] People in this phase may notice symptoms like fatigue, caused by a lower number of red blood cells, and stomach pain due to an enlarged spleen.[healthline.com] If patients experience symptoms related to CP-CML, they may claim fatigue, malaise and weakness, early satiety and a feeling of fullness, possibly abdominal pain and weight[symptoma.com]

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