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16 Possible Causes for Fatigue, Muscle Hypotonia, Wide Space Between the First and Second Toe

  • Down Syndrome

    The most commonly reported side effects were "diarrhoea, fatigue, insomnia, nausea and vomiting" (page 497; Prasher 2005 ).[doi.org] From Wikidata Jump to navigation Jump to search chromosomal disease characterized by flat-looking facial features and weak muscle tone (hypotonia) in infancy and is caused[wikidata.org] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org]

  • Dubowitz Syndrome

    Peripheral blood counts should be obtained in children with infectious illness or fatigue, as aplastic anemias have also been described [ 1, 2 ].[jmedicalcasereports.biomedcentral.com] Low or weak muscle tone 0001252 Neuroblastoma Cancer of early nerve cells 0003006 Otitis media Middle ear infection 0000388 Pes planus Flat feet Flat foot [ more ] 0001763[rarediseases.info.nih.gov] Perceived Fatigue in Spinal Muscular Atrophy: A Pilot Study. J Neuromuscul Dis . 2018 Dec 14. [Medline] . Puruckherr M, Mehta JB, Girish MR, et al.[emedicine.medscape.com]

  • Multiple Endocrine Neoplasia Type 2B

    However, most people with endocrine disease complain of fatigue and weakness.[webmd.com] Mucosal neuromas à GI symptoms, muscle hypotonia, chronic constipation due to hyperplasia of autonomic ganglia in the intestinal wall.[almostadoctor.co.uk] Figure 3 The first toe is longer than the others and there is a wide space between the first and second toe.[ijponline.biomedcentral.com]

  • Weaver Syndrome

    Dec 15, 2011 0 0 Diseases, Conditions, Syndromes New IOM report identifies five symptoms to diagnose chronic fatigue syndrome Myalgic Encephalomyelitis/Chronic Fatigue Syndrome—commonly[medicalxpress.com] Other common symptoms include hypertonia (increased muscle tone, tight muscles) as well as hypotonia (decreased muscle tone, "floppy" muscles) and a hoarse low-pitched cry[encyclopedia.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Atelosteogenesis Type 2

    They include diffuse leg pain, fatigue, decline in physical function and, in children, a failure to walk despite otherwise normal development.[socialstyrelsen.se] He had difficulty in walking, mild proximal muscular hypotonia in the lower extremities and hyperactive deep tendon reflexes.[nature.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Cutis Laxa

    This can lead to recurrent headaches, fatigue, and other irritations.[mccrackenmd.com] Individuals with EFEMP2 -related cutis laxa usually present with muscle hypotonia. Other common findings are arachnodactyly, joint laxity, and pectus deformities.[ncbi.nlm.nih.gov] Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br]

  • Russell-Silver Syndrome

    We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: May 13, 2019[patientslikeme.com] Generalized low muscle tone in neonate 0008935 Hyperhidrosis Excessive sweating Increased sweating Profuse sweating Sweating Sweating profusely Sweating, increased [ more[rarediseases.info.nih.gov] Meet a Child with Russell-Silver Medical and Dietary Needs Educational Supports Behavior and Sensory Supports Physical Activity, Trips, Events School Absences and Fatigue[gemssforschools.org]

  • Macrocephaly-Developmental Delay Syndrome

    The inevitable fatigue steadily wore on the nerves of Jerry and Mattie, who found themselves in arguments that they had never had before.[chginc.org] However, young AS patients may also exhibit feeding difficulties and muscle hypotonia.[clinchem.aaccjnls.org] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org]

  • Familial Congenital Nasolacrimal Duct Obstruction

    The disorder is characterized by bruising, fatigue, anemia, low blood platelet count and enlargement of the liver and spleen, and is caused by a hereditary deficiency of the[checkrare.com] Cramp Muscle Hypertonia Muscle Hypotonia Muscle Neoplasms Muscle Rigidity Muscle Spasticity Muscle Weakness Muscular Atrophy Muscular Atrophy, Spinal Muscular Diseases Muscular[medgene.med.harvard.edu] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org]

  • Kenny-Caffey Syndrome Type 1

    The disorder is characterized by bruising, fatigue, anemia, low blood platelet count and enlargement of the liver and spleen, and is caused by a hereditary deficiency of the[checkrare.com] Liver problems After infancy include: Hypotonia Muscle pain Breakdown of muscle tissue Peripheral neuropathy Infants with mitochondrial trifunctional protein deficiency are[wikidoc.org] space between the first and second toes.[medcraveonline.com]

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