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17 Possible Causes for Fatigue, Mutation in the CDK6 Gene, Personality Change

  • Glioblastoma Multiforme

    General symptoms for metastatic brain tumors include: Headaches Weakness on one side of the body Problems with balance Seizures Behavior, memory and personality changes Glioblastoma[uwhealth.org] Drugs to help treat fatigue or depression may be helpful.[web.archive.org] The inherited predisposition factors in pediatric HGG are as follows: germline mutations in tumor suppressor genes TP53 and neurofibromin 1 (NF1); oncogenic NTRK fusions [[doi.org]

  • Malignant Gastric Neoplasm

    Most cancers are caused by gene changes that happen during a person’s lifetime, but a person’s cancer risk can be higher if they have one of these rare inherited mutations[debbiesdream.org] The most common symptoms were, respectively: epigastric pain, vomiting, weigh loss, epigastric fullness and fatigue.[web.archive.org] Figure 5: Integrated molecular description of gastric cancer. a , Mutations, copy-number changes and translocations for select genes are shown across samples organized by[nature.com]

  • Gastric Adenocarcinoma

    Because there is no one risk factor directly associated with gastric cancer, there is no strict lifestyle change that can greatly decrease a person's risk of developing gastric[oncolink.org] A 56-year-old Malaysian woman with a past medical history of iron deficiency anemia presented with lower extremity edema and progressive fatigue of 1 month's duration.[ncbi.nlm.nih.gov] In Pt2, the SETBP1 gene (p.S944N) was mutated, as it is in myeloid malignancies ( 20 ), together with amplification of AKAP9 and CDK6 (cyclin-dependent kinase 6).[pnas.org]

  • Gastric Cancer

    Because there is no one risk factor directly associated with gastric cancer, there is no strict lifestyle change that can greatly decrease a person's risk of developing gastric[oncolink.org] , dyspnea, rash, neutropenia, anemia, and myalgia The most common adverse reactions associated with Herceptin in metastatic gastric cancer were neutropenia, diarrhea, fatigue[herceptin.com] Figure 5: Integrated molecular description of gastric cancer. a, Mutations, copy-number changes and translocations for select genes are shown across samples organized by molecular[nature.com]

  • Medulloblastoma

    […] in sensation on one side of the body Seizures Unusual sleepiness or change in energy level Change in personality or behavior Unexplained weight loss or weight gain More advanced[columbianeurosurgery.org] Toxicities related to drug administration included acute bradycardia with somnolence, headache, fatigue, and CSF pleocytosis consistent with chemical meningitis and dystonic[ncbi.nlm.nih.gov] Poor prognosis: Group 3, MYC amplification, photoreceptor/GABAergic gene expression Intermediate prognosis: Group 4, gene expression of neuronal/glutamatergic, CDK6 amplification[en.wikipedia.org]

  • Biliary Carcinoma

    If you are concerned about any changes you experience, please talk with your doctor.[cancer.net] Grade 1 and 2 toxic effects included mainly anorexia and fatigue.[ncbi.nlm.nih.gov] This tendency is the same as that for K-ras mutations and the pancreaticobiliary maljunction may override the effect of p53 gene mutations.[atlasgeneticsoncology.org]

  • Pancreatic Neoplasm

    Psychosocial Assess for the presence of irritability, depression, and personality changes.[medical-dictionary.thefreedictionary.com] They include yellowing of the skin and eyes, pain in the abdomen and back, weight loss and fatigue.[icd9data.com] Thus when mutations in the CDKN2A gene disrupt the function of p16(INK4), there is improper progression from the G1 to the S phase, allowing continued, uncontrolled cell proliferation[ncbi.nlm.nih.gov]

  • Acute Myelomonocytic Leukemia

    CML is an acquired leukemia, resulting from a change in a person's DNA. This change results in an uncontrolled growth of white cells.[nationalcmlsociety.org] A 48-year-old Japanese man was admitted to our hospital because of general fatigue, nasal bleeding, and petechiae on his extremities.[ncbi.nlm.nih.gov] In one-third we observed chromosome abnormalities (e.g. trisomy 8, del20q) and gain or loss of genes (e.g. NF1, RB1 and CDK6 ).[bmccancer.biomedcentral.com]

  • Rhabdomyosarcoma

    Shrieve, Demographics, stage distribution, and relative roles of surgery and radiotherapy on survival of persons with primary prostate sarcomas, Cancer Medicine, 7, 12, (6030[doi.org] General symptoms include weight loss, fatigue and sometimes the presence of a palpable mass. Other signs and symptoms vary on the basis of the site of the primary tumor.[symptoma.com] The discovery that p16 gene is mutated or deleted in a striking proportion of human tumors raised the possibility that abnormalities in p16 might predispose to cancer development[ncbi.nlm.nih.gov]

  • Neuroectodermal Tumor

    changes.[knowcancer.com] A 40-year-old male was admitted with complaints of nonproductive cough, exertional dyspnea, and fatigue since 4 months with a history of abdominal wall swelling which was[ncbi.nlm.nih.gov] Poor prognosis: Group 3, MYC amplification, photoreceptor/GABAergic gene expression Intermediate prognosis: Group 4, gene expression of neuronal/glutamatergic, CDK6 amplification[en.wikipedia.org]

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