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54 Possible Causes for Fatigue, Mutation in the WWOX Gene

  • Epithelial Ovarian Cancer

    TP53 and PTEN are among the best known tumor suppressor genes involved in EOC pathogenesis, but mutations have also been found in genes OPCML and WWOX, among others.[symptoma.com] Grade 3 fatigue occurred in both patients, resulting in a dose reduction of thalidomide, with toxicity otherwise acceptable.[ncbi.nlm.nih.gov] NACT provided better QOL in terms of fatigue (weight mean difference [WMD], -3.28; [95% CI: -3.99 to -2.57]), role functioning (WMD: 5.29 [95% CI: 4.44 to 6.14]), emotional[ncbi.nlm.nih.gov]

  • Reye Syndrome

    A few rare cases have been associated with mutations in the steroidogenic factor 1 ( SF1 or NR5A1 ) gene, the protein Wnt-4 ( WNT4 ) gene, and the CBX2, GATA4 and WWOX genes[rarediseases.org] Reye's syndrome Pathology Type Syndrome Cause(s) Interaction of aspirin with influenza Symptoms Stage 1: Vomiting, drowsiness, fatigue, loss of energy Stage 2: Aggression,[house.wikia.com] […] lethargy Mental confusion, hyperexcitability, disorientation, irritability, or memory loss Severe symptoms: seizures, loss of consciousness, cessation of breathing Irritability Fatigue[healthcommunities.com]

  • Ataxia

    The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.[ncbi.nlm.nih.gov] […] loss of balance and coordination, which usually occurs between five to 15 years of age. 5 People with FA experience progressive loss of coordination, muscle weakness, and fatigue[reatapharma.com] Drowsiness, fatigue, headache insomnia nausea and excess urination can also occur with baclofen use 17 .[multiplesystematrophy.org]

  • Familial Infantile Myoclonic Epilepsy

    The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation. Brain. 2014;137:411–9.[genomemedicine.biomedcentral.com] Medication Percent still taking Worst side effects Other side effects Most common side effects Valproic acid 54% 13% 4% Tremor (8%); Fatigue (7%) Clonazepam 64% 4% Fatigue[angelman.org] Drinking alcohol, which can lead to too little sleep and fatigue, is the strongest trigger of myoclonic jerks and tonic-clonic seizures.[webmd.com]

  • Spinocerebellar Ataxia Type 14

    Mutation in the WWOX gene, D. schematic of the WWOX gene). Figure adapted from WWOX.[epilepsygenetics.net] However, the SCL-90-R also includes a scale of somatic symptoms such as fatigue and muscle pain, and by excluding the somatization scale from the analysis, the correlation[bmcneurol.biomedcentral.com] Performing exome sequencing in the younger sister, the authors identified 16 genes with functionally relevant homozygous mutation and focused on the WWOX gene, coding for[epilepsygenetics.net]

  • Severe Neonatal-Onset Encephalopathy with Microcephaly

    Homozygous and compound heterozygous mutations in the WWOX gene (16q23) have been found in several families.[disorders.eyes.arizona.edu] Fatigue and headaches are common with fevers.[autoinflammatory-search.org] The mother had noticed frequent periods of fatigue during the day and a phobia of doors shutting.[jmg.bmj.com]

  • Primary Effusion Lymphoma

    In PEL the p53 and PTEN genes are rarely mutated. P53 mutations accumulate after chemotherapy ( Petre et al., 2007 ; Chen et al., 2010 ).[journal.frontiersin.org] In the second case, an HIV-uninfected 94-year-old man was affected by anorexia, fatigue, shortness of breath and nonproductive cough.[ncbi.nlm.nih.gov] Epstein-Barr virus (EBV) A type of herpes virus that causes mononucleosis (a highly infectious disease that causes fever, fatigue, malaise and sore throat).[cancer.ca]

  • Autosomal Recessive Spinocerebellar Ataxia 8

    Mutation in the WWOX gene, D. schematic of the WWOX gene). Figure adapted from WWOX.[epilepsygenetics.net] Symptoms of cerebellar ataxia include: Behavior or personality changes Changes in your voice Dizziness Fatigue Headaches Low muscle tone Muscle tremors Slurred speech Trouble[webmd.com] It has side effects such as sedation, fatigue or loss of libido among others.[bcm.edu]

  • X-Linked Spastic Paraplegia Type 2

    Koenig, The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation. Brain, 2014. 137(Pt 2): p. 411-9.[hih-tuebingen.de] We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: January 30, 2019[patientslikeme.com] Fatigue: The extra effort required for walking, because of muscle weakness in the legs. 57. Various medications prescribed for HSP cause drowsiness & fatigue. 58.[slideshare.net]

  • Esophageal Carcinoma

    Copy-number analysis revealed higher rates of deletions of putative fragile site genes FHIT or WWOX, suggestive of differences in the underlying genomic instability between[nature.com] Side effects from radiation therapy may include fatigue, mild skin reactions, soreness in the throat and esophagus, difficulty or pain with swallowing, upset stomach, nausea[cancer.net] Other adverse effects of radiation therapy include nausea, vomiting, anorexia, fatigue, esophagitis, excess esophageal mucus production, xerostomia, stricture, radiation pneumonitis[msdmanuals.com]

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