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12 Possible Causes for Fatigue, Neonatal Hypotonia, Wide Space Between the First and Second Toe

  • Down Syndrome

    Frequently the first feature noticed is hypotonia. Neonatal features of Down's syndrome General: Hyperflexibility. Muscular hypotonia.[patient.info] The most commonly reported side effects were "diarrhoea, fatigue, insomnia, nausea and vomiting" (page 497; Prasher 2005 ).[doi.org] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org]

  • Atelosteogenesis Type 2

    Hydrocephalus Seizures Survival beyond neonatal period Normal karyotvpe - t 111 3 I4 0 19 2 I5 t - 515 10110 5 I5 NR 315 014 215 0 I4 515 013 414 NR 515 111 415 212 515 111[documents.tips] They include diffuse leg pain, fatigue, decline in physical function and, in children, a failure to walk despite otherwise normal development.[socialstyrelsen.se] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Russell-Silver Syndrome

    hypotonia Generalized low muscle tone in neonate 0008935 Hyperhidrosis Excessive sweating Increased sweating Profuse sweating Sweating Sweating profusely Sweating, increased[rarediseases.info.nih.gov] We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: May 13, 2019[patientslikeme.com] Meet a Child with Russell-Silver Medical and Dietary Needs Educational Supports Behavior and Sensory Supports Physical Activity, Trips, Events School Absences and Fatigue[gemssforschools.org]

  • Familial Congenital Nasolacrimal Duct Obstruction

    Patients with FOXG1 pathogenic variants often demonstrate normal birth parameters, followed by hypotonia and extreme irritability in the neonatal period.[chginc.org] The disorder is characterized by bruising, fatigue, anemia, low blood platelet count and enlargement of the liver and spleen, and is caused by a hereditary deficiency of the[checkrare.com] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org]

  • Weaver Syndrome

    Additional features that may be present include neonatal hypotonia, seizures, scoliosis, strabismus, congenital heart defects, and cancer (Kaneko et al. 1987 ; Hersh et al[ncbi.nlm.nih.gov] Dec 15, 2011 0 0 Diseases, Conditions, Syndromes New IOM report identifies five symptoms to diagnose chronic fatigue syndrome Myalgic Encephalomyelitis/Chronic Fatigue Syndrome—commonly[medicalxpress.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Nicolaides-Baraitser Syndrome

    The neonatal period was complicated by muscular hypotonia, feeding difficulties, and failure to thrive. Bilateral inguinal hernias were operated.[ncbi.nlm.nih.gov] Children with these conditions may suffer chronic pain, injuries, fatigue and complex multi-systemic problems.[geneticdisordersuk.org] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • MORM Syndrome

    hypotonia Low muscle tone, in neonatal onset 0001319 Pes planus Flat feet Flat foot [ more ] 0001763 Reduced visual acuity Decreased clarity of vision 0007663 Short metacarpal[rarediseases.info.nih.gov] The most common symptoms include dry eyes, dry mouth, fatigue and musculoskeletal pain.[sjogrens.org] Hypotonia Miles-Carpenter syndrome miliaria Milner Khallouf Gibson Syndrome Mirhosseini-Holmes-Walton Syndrome Mirizzi Syndrome Mitchell-Riley Syndrome mitochondrial DNA[rgd.mcw.edu]

  • Baraitser Syndrome

    The first girl had neonatal hypotonia, mental retardation, and generalized tonic-clonic seizures.[omim.org] Children with these conditions may suffer chronic pain, injuries, fatigue and complex multi-systemic problems.[geneticdisordersuk.org] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Macrocephaly-Developmental Delay Syndrome

    Out of these clinical criterion, seven clinical findings (neonatal hypotonia, midline facial nevus flammeus, connective tissue defect, developmental delay, toe syndactyly[ijpd.in] The inevitable fatigue steadily wore on the nerves of Jerry and Mattie, who found themselves in arguments that they had never had before.[chginc.org] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org]

  • Tricho-Oculo-Dermo-Vertebral Syndrome

    hypotonia Visual loss Edema Microglossia Retinal dysplasia Stridor Selective tooth agenesis Lacrimal duct atresia Patchy alopecia Oval face Hyperconvex nail Ankyloblepharon[mendelian.co] The disorder is characterized by bruising, fatigue, anemia, low blood platelet count and enlargement of the liver and spleen, and is caused by a hereditary deficiency of the[checkrare.com] space between the first and second toes, and fusion of carpal and tarsal bones.[findzebra.com]

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