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8,135 Possible Causes for Fatigue, Progressive Disease

  • Primary Progressive Multiple Sclerosis

    “We also have additional data that shows we have an effect on fatigue (a very important aspect of MS, 75% of patients have fatigue).[mdmag.com] The majority of patients starts with relapsing remitting (RR) disease; approximately 50-60% of these patients progress to secondary progressive (SP) disease.[ncbi.nlm.nih.gov] Fatigue is also common with this and all other forms of multiple sclerosis.[verywell.com]

  • Primary Sclerosing Cholangitis

    Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of bile ducts..Patients with PSC usually presents with fatigue, jaundice and pruritus.[ncbi.nlm.nih.gov] Primary sclerosing cholangitis (PSC) is a chronic, progressive disease characterized by inflammatory and fibrosing strictures of the biliary tree.[ncbi.nlm.nih.gov] Moreover, they experienced less itch (p 0.03) and less Fatigue (p 0.03) and had better Cognitive Abilities (p 0.04) as assessed by the PBC-40 and PBC-27 questionnaires.[ncbi.nlm.nih.gov]

  • Recurrent Small-Cell Carcinoma of the Lung

    Twenty (40%) patients had stable disease (SD) and 13 (26%) had progressive disease (PD).[ncbi.nlm.nih.gov] , fatigue, and alanine aminotransferase/aspartate aminotransferase elevations for linsitinib.[ncbi.nlm.nih.gov] Treatment was generally well tolerated and the most frequent adverse events were neutropenia, fatigue, nausea, vomiting, and constipation.[ncbi.nlm.nih.gov]

  • Chronic Kidney Insufficiency

    In fact, drowsiness, fatigue, and an overall lack of energy are encountered in the majority of patients, along with pruritus and pain.[symptoma.com] The majority of patients with chronic kidney disease rarely progress beyond Stage 2.[medicalnewstoday.com] End stage renal disease causes weight loss, nausea and vomiting, fatigue, difficulty breathing and seizures.[kidneyandhypertensioncare.com]

  • Interstitial Lung Disease

    A 74-year-old Japanese man who received pazopanib for the treatment of femoral leiomyosarcoma and lung metastasis presented with dyspnea and fatigue.[ncbi.nlm.nih.gov] Often a period of observation is appropriate to assess whether the disease resolves spontaneously or progresses.[doi.org] Five weeks after osimertinib initiation, he developed general fatigue and dyspnea.[ncbi.nlm.nih.gov]

  • Idiopathic Pulmonary Fibrosis

    Almost all patients reported at least one adverse event, and more patients on interferon gamma-1b group had constitutional signs and symptoms (influenza-like illness, fatigue[ncbi.nlm.nih.gov] However, accelerated disease progression after nintedanib discontinuation has never been reported.[ncbi.nlm.nih.gov] The progression of IPF lead to a decline in forced vital capacity (FVC), dyspnea, cough, continuous sleep interruptions, resulting in increased fatigue and deteriorating quality[ncbi.nlm.nih.gov]

  • Motor Neuron Disease

    The aim of the study was to explore the prevalence of VGKC-complex Abs in slow-progression motor neuron disease (MND).[ncbi.nlm.nih.gov] All studies assessed fatigue using the Fatigue Severity Scale (FSS; scale from 9 to 63, higher scores indicate more fatigue).[ncbi.nlm.nih.gov] Here we illustrate a 74-year-old patient presenting with clinical signs of slowly progressive motor neuron disease.[ncbi.nlm.nih.gov]

  • Amyotrophic Lateral Sclerosis

    All studies assessed fatigue using the Fatigue Severity Scale (FSS; scale from 9 to 63, higher scores indicate more fatigue).[ncbi.nlm.nih.gov] This review examined current research related to moderate exercise for maintaining independence without accelerating disease progression in persons with ALS.[ncbi.nlm.nih.gov] Individual muscle strength, fatigue and spasticity must all be taken into account when discussing exercise with persons with ALS.[ncbi.nlm.nih.gov]

  • Chronic Kidney Disease

    We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: May 13, 2019[patientslikeme.com] It is generally believed that significant renal ablation leads to hyperfiltration and eventually progressively worsening chronic kidney disease.[ncbi.nlm.nih.gov] Symptoms develop slowly and in advanced stages include anorexia, nausea, vomiting, stomatitis, dysgeusia, nocturia, lassitude, fatigue, pruritus, decreased mental acuity,[msdmanuals.com]

  • Young-Onset Parkinson Disease

    YOPD has a slower disease progression and a greater incidence and earlier appearance of levodopa-induced motor complications; namely, motor fluctuations and dyskinesias.[dovepress.com] There was a consensus regarding difficult symptoms to cope with in employment with fatigue having the biggest impact and other symptoms being: cognitive changes, stress, anxiety[nrl.northumbria.ac.uk] “The primary symptoms of fibromyalgia include widespread musculoskeletal pain, severe fatigue, and disturbed sleep.[allsup.com]

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