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265 Possible Causes for Fatigue, Progressive Polyneuropathy, Pruritus

  • Diabetes Mellitus

    Myasthenia gravis (MG) is an acquired disease of the neuromuscular junctions characterized by muscular weakness and fatigue, with a prevalence of 50-125 cases per million[ncbi.nlm.nih.gov] […] outweighed by the benefits of reducing cardiovascular risk. [ 8 ] Presentation Patients with all types of diabetes may present with polyuria, polydipsia, lethargy, boils, pruritus[patient.info] Nine weeks after initiation, he developed fatigue and polyuria with blood glucose 336 mg/dL, c-peptide 0.6 ng/mL, A1C8.2% and GAD antibodies 28.4 U/mL (normal, 1 U/mL).[ncbi.nlm.nih.gov]

  • Paraneoplastic Syndrome

    The authors present a case report of a woman with presumed contact dermatitis who was diagnosed with breast cancer in the setting of progressive fatigue and muscle weakness[ncbi.nlm.nih.gov] This 59-year-old man developed ophthalmoplegia, dysarthria, dysphagia, pruritus, ataxia, corticobulbar and corticospinal signs in association with prostate cancer.[ncbi.nlm.nih.gov] We report a fatal case of severe chronic progressive axonal polyradiculoneuropathy in association with this antibody.[doi.org]

  • Multiple Myeloma

    She developed G2 AEs, including nausea and fatigue. The cardiac amyloidosis worsened, and she died of heart and renal failure.[ncbi.nlm.nih.gov] Her pruritus resolved, but the lesions persisted. Footnotes Competing interests: None declared. This article has been peer reviewed.[cmaj.ca] […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[radiopaedia.org]

  • Waldenstrom Macroglobulinemia

    Neuropathy is typically slowly progressive, distal, symmetrical, and sensorimotor.[emedicine.medscape.com] The consensus panel agreed that initiation of therapy was appropriate for patients with constitutional symptoms such as recurrent fever, night sweats, fatigue due to anemia[ncbi.nlm.nih.gov] The most common symptoms at diagnosis were fatigue (77.8%) and bleeding (20%), while only 6 patients (6.7%) were asymptomatic.[ncbi.nlm.nih.gov]

  • Chronic Alcoholism

    Chronic alcoholism can affect the circulatory system, increase the risk of anemia and lead to complaints like fatigue, breathlessness and lightheadedness .[epainassist.com] Generalised pruritus Generalised skin itching ( pruritus ) may occur due to the build up of poorly metabolised substances that stimulate nerve endings in the skin.[dermnetnz.org] The most common symptoms of alcohol withdrawal include: Shakiness, tremors or Delirium tremens Anxiety Irritability Depression Fatigue Mood swings Bad dreams or nightmares[addictions.com]

  • Vasculitis

    Neuropathy Sensory or Sensory-Motor General patterns Mononeuritis multiplex (13%) Asymmetric polyneuropathy (85%) Distal symmetric polyneuropathy (2%) More slowly progressive[neuromuscular.wustl.edu] Aspects of disease relevant for AAV patients were: fatigue and lack of energy; visual abnormalities; neuropathy; renal impairment; arthritis, and sinusitis.[ncbi.nlm.nih.gov] The lesions may be asymptomatic or associated with burning, pruritus, or pain.[clinicaladvisor.com]

  • Anxiety Disorder

    The neurological signs are often a progressive spastic paraparesis, cerebellar ataxia, polyneuropathy, and cognitive impairment.[ncbi.nlm.nih.gov] […] characterized by at least 6 months of pervasive and excessive anxiety; recurring worry about common events; and physical symptoms, such as muscle tension, insomnia, and fatigue[doi.org] However, GAD was also highly associated with impaired psychological well-being, stress and fatigue (p CONCLUSIONS: In AMI patients, GAD was independently associated with less[ncbi.nlm.nih.gov]

  • Chronic Inflammatory Demyelinating Polyneuropathy

    Shortly after HSCT the patient developed progressive polyneuropathy of the lower legs and hypoesthesia. Five months later a severe dementia followed.[ncbi.nlm.nih.gov] We present a patient with CIDP in whom fatigue remained the only symptom, hereby stressing the importance of adding this disease to the differential diagnosis of fatigue.[ncbi.nlm.nih.gov] […] were local reactions (ie, swelling, redness, heat, pain, and itching at the injection site), headache, diarrhea, fatigue, back pain, nausea, extremity pain, cough, rash, pruritus[prnewswire.com]

  • Systemic Scleroderma

    The severity of the scleroderma patient fatigue is not on the same level as a ‘healthy’ person would feel fatigue.[sclerodermanews.com] The steroids help with the pruritus and may lead to some lesional thinning.[clinicaladvisor.com] […] due to systemic sclerosis Progressive systemic sclerosis Scleredema Scleredema buschkes Scleroderma Scleroderma induced by chemical, including drugs Scleroderma of lung Scleroderma[icd9data.com]

  • Systemic Amyloidosis

    Hou X, Aguilar MI, Small DH (2007) Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.[doi.org] These deposits damage normal tissues, leading to the symptoms or signs of this illness: Bleeding in the skin Fatigue Irregular heartbeat Numbness of hands and feet Rash Shortness[nlm.nih.gov] This case demonstrates an unusual presentation of primary systemic amyloidosis consisting of arthritis and intense debilitating pruritus without primary skin lesions for a[ncbi.nlm.nih.gov]

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