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18 Possible Causes for Fatigue, Proximal Interphalangeal Joint Space Narrowed

  • Osteoarthritis

    Hand X-rays showed joint space narrowing, osteophytosis and bone sclerosis of the proximal interphalangeal (PIP) joints.[ncbi.nlm.nih.gov] Interestingly, along with improvements in her knee and hips her other comorbidities such as ankylosing spondylitis, depression, anxiety, and fatigue exhibited marked improvement[ncbi.nlm.nih.gov] The central activation ratio ( P .001, Cohen d -1.74) and fatigue index ( P .003, Cohen d -0.95) were lower among patients only early after ACLR.[ncbi.nlm.nih.gov]

  • Hemochromatosis

    Involvement of proximal interphalangeal joints, radiographic joint space narrowing and cartilage destruction is often evident in hemochromatosis.[clinicaladvisor.com] Symptoms greatly vary among patients and include fatigue, abdominal pain, arthralgias, impotence, decreased libido, diabetes, and heart failure.[ncbi.nlm.nih.gov] Early symptoms may be nonspecific and often include joint pain, fatigue and weakness.[arthritis.org]

  • Rheumatoid Arthritis

    Abbreviations DAS: Disease Activity Score DMARD: disease-modifying antirheumatic drugs JSN: joint space narrowing MRI: magnetic resonance imaging PIP: proximal interphalangeal[doi.org] No study assessed long-term changes in fatigue. Treatment with biologic interventions in patients with active RA can lead to a small to moderate improvement in fatigue.[ncbi.nlm.nih.gov] ; NNTB 10, 95% CI 6 to 33) demonstrating a small beneficial effect upon fatigue.[ncbi.nlm.nih.gov]

  • Arthritis

    Abbreviations DAS: Disease Activity Score DMARD: disease-modifying antirheumatic drugs JSN: joint space narrowing MRI: magnetic resonance imaging PIP: proximal interphalangeal[doi.org] Fatigue (tiredness). Loss of appetite. Difficulty with daily living activities such as walking, dressing, and play.[web.archive.org] Fatigue improved, which may in turn facilitate physical activity participation.[ncbi.nlm.nih.gov]

  • Primary Hyperparathyroidism

    Review Topic QID: 106788 1 Joint space narrowing at the proximal and distal interphalangeal joints 2 Osteoid matrix accumulation around bony trabeculae 3 Subperiosteal cortical[medbullets.com] We present a case of a 54-year-old woman with fatigue, myalgia, and poor concentration who was found to have hypercalcemia (corrected calcium, 11.2 mg/dL) and elevated parathyroid[ncbi.nlm.nih.gov] A 46 year-old female patient presented to the hospital with ongoing and progressively increasing fatigue, severe nausea and vomiting, loss of appetite, constipation, palpitations[ncbi.nlm.nih.gov]

  • Progressive Pseudorheumatoid Dysplasia

    Figure 2 Bony enlargement of metacarpophalangeal andproximal interphalangeal joints Figure 3 X-ray of the hands revealing swelling of themetacarpophalangeal and proximal[docslide.net] The disease manifests around the age of three to eight years and progresses with symptoms of early fatigue, muscle weakness, joint swelling and stiffness.[ncbi.nlm.nih.gov] Some of the symptoms of Progressive pseudorheumatoid arthropathy of childhood: Fatigue Muscle weakness Waddling gait Bowed legs Joint stiffness When should you consult a doctor[sehat.com]

  • Enthesitis-Related Arthritis

    Long-term sequelae of polyarticular disease includes periarticular osteopenia, generalized increase in the size of epiphyses, accelerated bone age, narrowed joint spaces ([emedicine.medscape.com] We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: May 13, 2019[patientslikeme.com] When the disease is active, up to 10% of patients will develop systemic manifestations such as fever, weight loss, fatigue, muscle weakness, muscle atrophy, and lymphadenopathy[symptoma.com]

  • Juvenile Psoriatic Arthritis

    Joints mostly involved are distal interphalangeal, proximal interphalangeal, metatarsophalangeal, and metacarpophalangeal joints.[boneandspine.com] […] the fingers and toes look like sausages a red, itchy, and scaly rash on the knees, elbows, scalp, face, and buttocks joints that are deformed from swelling pitted nails fatigue[healthline.com] Although there is no cure for this condition, understanding the disorder and knowing what to expect can help reduce discomfort, stress, and fatigue.[my.clevelandclinic.org]

  • Arthropathy

    Joints frequently involved in chronic arthritis are ankles, knees, hands, wrist, and metacarpophalangeal and proximal interphalangeal joints, rarely, the sacroiliac and temporomandibular[medcraveonline.com] Bone erosion Systemic signs of arthritis such as fatigue Arthropathy may also include joint conditions caused by physical trauma to joints, but is traditionally used to describe[en.wikipedia.org] These two presentations of RA may differ significantly with respect to mode of onset, prevalence of associated systemic symptoms (eg, fatigue, weight loss, depression), criteria[ncbi.nlm.nih.gov]

  • Hereditary Koilonychia

    Involvement of proximal interphalangeal joints, radiographic joint space narrowing and cartilage destruction is often evident in hemochromatosis.[clinicaladvisor.com] CMV IgM: positive known diagnosis of sickle cell disease in patient and/or parents; prior painful vaso-occlusive crises; fatigue, poor exercise tolerance, persistent pain[bestpractice.bmj.com] The disorder is characterized by bruising, fatigue, anemia, low blood platelet count and enlargement of the liver and spleen, and is caused by a hereditary deficiency of the[checkrare.com]

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