Possible Causes for fetal finger pads Pitt-Hopkins Syndrome […] tips and wide and flat palate Broad finger tips and wide and flat palate Strabismus, scoliosis, sacral dimple, fetal finger pads, overriding 5th toe, and short metatarsal [ncbi.nlm.nih.gov] People with PTHS can have particularly fleshy pads in the tips of their fingers or toes.These are known as fetal pads. Short sightedness or a squint. Undescended testes. [pitthopkins.org.uk] Other features include a single (simian) palmar crease, long, slender fingers, flat feet and cryptorchidism (in males). The presence of "fetal finger pads" is common. [en.wikipedia.org] Kabuki Syndrome finger pads and distinct facial features. [ncbi.nlm.nih.gov] People with KS may also have unusual fingerprints with fleshy pads at the fingertips. These are called fetal finger pads. [thinkgenetic.com] […] is smaller in size Fetal finger pads are persistent Strabismus might be present at the level of the eyes The teeth may be widely spaced Hypodontia can be encountered in certain [mddk.com] Goldberg-Shprintzen Syndrome Additional dysmorphic features may include maxillary hypoplasia, hypodontia, high arched palate, short neck, small hands, brachydactyly, fifth finger clinodactyly, fetal finger [orpha.net] We also noted maxillary hypoplasia, hypodontia, high-arched palate, short neck, small hands, brachydactyly, clinodactyly of the fifth fingers, fetal finger pads and flatfoot [doi.org] pads and flatfoot. [orpha.net] Rubinstein-Taybi Syndrome […] persistent fetal pads clinodactyly of the fifth fingers skull and central nervous system microcephaly intellectual retardation (IQ 35-50) congenital cardiac abnormalities [radiopaedia.org] […] persistent fetal pads, clinodactyly of the fifth fingers skull and central nervous system microcephaly mental retardation (IQ 35-50) congenital cardiac abnormalities: reported [radiopaedia.org] finger pads (31%), duplicated longitudinal bracketed epiphysis (kissing delta phalanx), syndactyly, polydactyly, ulnar deviation of the thumb, congenital or juvenile glaucoma [faoj.org] Eye Muscle Disorder […] or vertebrae; persistent finger fetal pads, mild to moderate intellectual disability; and short stature. [apraxia-kids.org] Characteristics include facial features such as arched eyebrows with sparseness in the outer half, misshapen or prominent ears, depressed nasal tip; skeletal abnormalities of the fingers [apraxia-kids.org] Drayer Syndrome The following clinical features are also frequent: fifth finger clinodactyly and small feet/hands, syndactyly of the fingers or toes, persistent fetal finger pads and a single [orpha.net] Smith-Magenis Syndrome finger pads, and polydactyly. [orpha.net] finger pads, and polydactyly ( Figure 2 ; Table 1 ). 1, 7, 16, 17, 18 Otolaryngological problems such as hearing loss, velopharyngeal insufficiency, a hoarse deep voice, [doi.org] Other skeletal anomalies include brachydactyly, scoliosis, 5th-finger clinodactyly, 2/3 toe syndactyly, forearm and elbow limitations, vertebral anomalies, persistent fetal [orpha.net] Legius Syndrome finger pads (lumps on fingertips; see photos below) Atrial or ventricular septal defects Wide chest/widely spaced nipples Undescended testicles in boys Hypertrophic cardiomyopathy [forgottendiseases.org] […] following are common problems in NS: Common clinical features of Noonan Syndrome Sunken chest and pigeon chest occurring together (pectus excavatum and pectus carinatum) Fetal [forgottendiseases.org] Colpocephaly Skin biopsy normal ie not cockayne,Reduced subcutaneous fat,Family history of x-linked ichthyosis,STS normal,Fetal pads on feet,Long fingers and toes,Red palms,Coarse face [databases.lovd.nl] pads; eczema (HP:0000964); no cutis marmorata (-HP:0000965); no seizures (-HP:0001250); no growth abnormality (-HP:0001507); abnormal vision (HP:0000504); no hearing loss [databases.lovd.nl] finger pads; birth feeding problems 3y; seizures (HP:0001250); speech delayed (HP:0000750); contact problems; anteverted nares (HP:0000463); normal philtrum (-HP:0000288) [databases.lovd.nl] Mowat-Wilson Syndrome […] joints) and Kabuki syndrome (persistent fetal fingertip pads). [childnervoussystem.blogspot.com] The hands provide specific clues in Coffin–Lowry syndrome (short, soft hands with hyperextensible joints and tapering fingers), Nicolaides–Baraitser syndrome (prominent interphalangeal [childnervoussystem.blogspot.com] 3q29 Microdeletion The following clinical features are also frequent: fifth finger clinodactyly and small feet/hands, syndactyly of the fingers or toes, persistent fetal finger pads and a single [orpha.net] Blepharofacioskeletal Syndrome […] with minimal interphalangeal webbing and fetal finger pads ( Figure 1f and ). [nature.com] […] with a flat midface, hypertelorism, epicanthic folds, depressed, flat nasal bridge, bilateral microtia, small mouth, some webbing of the neck and camptodactyly of the fifth fingers [nature.com] Angelman Syndrome Other features include a single (simian) palmar crease, long, slender fingers, flat feet and cryptorchidism (in males). The presence of fetal pads is common. [en.wikipedia.org] Baraitser-Winter Syndrome Fetal pads as a clue to the diagnosis of Pitt-Hopkins syndrome. Am J Med Genet A. Jul;155A(7):1685-9.33. 34. Payne M, Rupar CA, Siu GM and Siu VM (2011). [lhsc.on.ca] Multiple Congenital Anomalies - Hypotonia - Seizures Type 3 The distal edge of the nail plates adhered to the very distal tips of the fingers and toes. There were fetal pads on the fingers and toes. [nature.com] Noonan Syndrome pads in fingers and toes (70%). [scielo.br] H, Patient O1409410 aged 12 years showing down‐slanting palpebral fissures, palpebral ptosis, low‐set posteriorly rotated ears and fetal finger‐tip pads. [onlinelibrary.wiley.com] […] stature (71%); craniofacial dysmorphisms, especially hypertelorism, ptosis, downslanting of the palpebral fissures; short or webbed neck (87%); cardiac anomalies (65%), and fetal [scielo.br] Autosomal Dominant Mental Retardation Type 21 Fetal pads as a clue to the diagnosis of Pitt-Hopkins syndrome. Am J Med Genet A. 2011;155A(7):1685–9. 57. Stavropoulos DJ, MacGregor DL, Yoon G. [ojrd.biomedcentral.com] Mitochondrial Disease […] or vertebrae; persistent finger fetal pads, mild to moderate intellectual disability; and short stature. [apraxia-kids.org] Characteristics include facial features such as arched eyebrows with sparseness in the outer half, misshapen or prominent ears, depressed nasal tip; skeletal abnormalities of the fingers [apraxia-kids.org] Growth Delay-Hydrocephaly-Lung Hypoplasia Syndrome Dermatoglyphic abnormalities are typically reported with persistent fetal volar pads, they are part of the cardinal signs. [omicsonline.org] Musculoskeletal abnormalities present in 88% of cases [ 4 ], are varied, they include brachydactyly type 5, brachymesophalangy, clinodactyly of the 5th finger, scoliosis, [omicsonline.org] Intestinal Pseudo-Obstruction - Patent Ductus Arteriosus - Natal Teeth The terminal phalanges of the fingers tend to be broad, and persistent fetal fingertip pads are common. [docplayer.net] Postaxial polydactyly of the feet does occur, as does (partial) syndactyly of the second and third toes or third and fourth fingers. [docplayer.net] Multiple Congenital Anomalies The distal edge of the nail plates adhered to the very distal tips of the fingers and toes. There were fetal pads on the fingers and toes. [nature.com] Jacobsen Syndrome Hands show cutaneous syndactyly, flat finger pads with fetal tubercule, thin fingers, large 1 st interphalangeal joints, hypoplastic hypotenar regions, abnormal palmar creases [ncbi.nlm.nih.gov] pads with fetal tubercule Thin fingers, large 1 st interphalangeal joints Hypoplastic hypotenar regions Abnormal palmar creases Hypoplastic tenar Feet Stubby and flat feet [ncbi.nlm.nih.gov] […] philtrum Flat philtrum V-shape mouth Thin upper lip Retrognathia High arched palate Thick lower lip Dental anomalies Neck Short neck Webbed neck Hands Cutaneous syndactyly Flat finger [ncbi.nlm.nih.gov] Microcornea pads of digits; [Feet]; Syndactyly; Clinodactyly; Fetal pads of digits SKIN, NAILS, HAIR: [Skin]; Fetal pads of digits NEUROLOGIC: [Central nervous system]; Mental retardation [findzebra.com] Hydroureter SKELETAL: [Spine]; Scoliosis; Exaggerated lumbar lordosis; [Limbs]; Achilles tendon shortening; [Hands]; Double thumbs (in some patients); Syndactyly; Clinodactyly; Fetal [findzebra.com] Celosomia Systemic findings include mild to moderate mental retardation, fetal pads, and cleft palate. [clinicalgate.com] Blue Sclera These prominent finger pads are called fetal finger pads because they normally occur in human fetuses; in most people they disappear before birth.A wide variety of other health [ncbi.nlm.nih.gov] People with Kabuki syndrome may also have fingerprints with unusual features and fleshy pads at the tips of the fingers. [ncbi.nlm.nih.gov] Pitt-Hopkins-Like Syndrome Type 1 Other features include a single (simian) palmar crease, long, slender fingers, flat feet and cryptorchidism (in males). The presence of "fetal finger pads" is common. [en.wikipedia.org] fetal finger pads, palmar creases, and postnatal growth restriction and microcephaly) are frequently seen (de Winter et al., Reference de Winter, Baas, Bijlsma, van Heukelingen [cambridge.org] pads on the fingertips and toes (persistent fetal pads). [rarediseases.org] Ring Chromosome 19 Bilaterally, thumbs were short; he also had short fifth fingers with clinodactyly, brachydactyly, and tapered fingers. Fetal fat pads were present. [nature.com] Dauwerse-Peters Syndrome Terminal broadening of the phalanges of the fingers, persistent fetal pads, clinodactyly of the fifth finger, overlapping of the toes, and angulation deformities of the thumbs [ommbid.mhmedical.com] fetal fingertip pads and overlapping toes. [atlasgeneticsoncology.org] Other extremities abnormalities include angulation deformities of the thumbs and halluces, broad distal phalanges of other fingers, clinodactyly of the 5th finger, persistent [atlasgeneticsoncology.org] Blepharophimosis - Intellectual Disability Syndrome Type Verloes finger pads Horizontal palmar creases Syndactyly NeuromuscularAgenesis of corpus callosum Congenital hypotonia GIAnal anomalies Genitourinary problems Chronic constipation [documents.tips] […] palate Dental crowding Maxillary hypoplasia Micrognathia/retrognathia Open mouth Frontal hair upsweep Small ears HandLong hyperextensible digits Broad thumbs Persistent fetal [documents.tips] Pashayan Syndrome […] with minimal interphalangeal webbing and fetal finger pads (Figure 1f and ). [nature.com] […] with a flat midface, hypertelorism, epicanthic folds, depressed, flat nasal bridge, bilateral microtia, small mouth, some webbing of the neck and camptodactyly of the fifth fingers [nature.com]
