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2,188 Possible Causes for Fever, Hepatomegaly, Thrombocytopenia

  • Infectious Mononucleosis

    A 49-year-old man with diabetic mellitus suffered from IM with fever, pharyngitis, parotiditis with lymphadenopathies, thrombocytopenia and splenomegaly.[ncbi.nlm.nih.gov] The patient showed severe hepatomegaly incidentally, and dual positivity of Immunoglobulin (Ig) M to Epstein-Barr virus (EBV) viral capsid antigen (VCA) and cytomegalovirus[ncbi.nlm.nih.gov] You don't usually get glandular fever more than once.[nhs.uk]

  • Malaria

    […] describ the case of a young soldier who, after returning from Central Africa, presented a fever associated with petechial purpura and gingivorrhagia, hemogram showed deep thrombocytopenia[ncbi.nlm.nih.gov] Patients with heavy hepatocyte load may present with hepatomegaly.[symptoma.com] Fever was not reported with this patient.[ncbi.nlm.nih.gov]

  • Rocky Mountain Spotted Fever

    This child had no serious bleeding manifestations and minimal hemorrhagic skin manifestations despite severe RMSF, concurrent thrombocytopenia, as well as the coagulation[ncbi.nlm.nih.gov] Hepatomegaly may be present, but jaundice is infrequent. Nausea and vomiting are common. Localized pneumonitis may occur.[msdmanuals.com] Rocky Mountain spotted fever and Mediterranean spotted fever are rickettsial infections primarily of endothelial cells that normally have a potent anticoagulant function.[ncbi.nlm.nih.gov]

  • Malignant Histiocytosis

    The terminal event was characterized by fever, hepatosplenomegaly, thrombocytopenia, and a leukemic blood picture.[ncbi.nlm.nih.gov] Most patients presented with systemic symptoms and lymphadenopathy (92%), splenomegaly (100%) and hepatomegaly (67%).[ncbi.nlm.nih.gov] A 70-year-old woman was admitted for evaluation of hepatosplenomegaly, fever and elevated serum LDH levels.[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    The combination of thrombosis, splenomegaly, and thrombocytopenia (TST) is challenging because anticoagulants are indicated but thrombocytopenia may increase the bleeding[ncbi.nlm.nih.gov] […] characterized by episodes of hemolytic anemia, hemoglobinuria (chiefly at night), pallor, icterus or bronzing of the skin, a moderate degree of splenomegaly, and sometimes hepatomegaly[medical-dictionary.thefreedictionary.com] Thromboses, as observed in our case, may be associated with fever and marked inflammation.[ncbi.nlm.nih.gov]

  • Chronic Lymphocytic Leukemia

    There is no or little evidence of anemia or thrombocytopenia.[symptoma.com] […] of the left zygomatic region; anterior nasal bleeding; pustulous non-itching lesions at the cervical region and posterior thorax; enlarged bilateral axillary lymph nodes; hepatomegaly[ncbi.nlm.nih.gov] The symptoms of this infection range from a silent infection to fever, enlargement of the liver and spleen, weight loss, and pancytopenia.[ncbi.nlm.nih.gov]

  • Systemic Lupus Erythematosus

    Blood platelet counts (BPCs) of 20   10/L represent severe thrombocytopenia, and a BPC of 21 to 50   10/L indicates moderate thrombocytopenia.[ncbi.nlm.nih.gov] Other signs are: Pancreatitis, Lupus Enteropathy, Hepatitis and Hepatomegaly 5. Systemic Fever, Malaise/Fatigue, Lymphadenopathy, Weight loss 6.[fidanoski.ca] This FDG distribution pattern should be kept in mind when PET is performed for etiological investigation of fever of unknown origin.[ncbi.nlm.nih.gov]

  • Familial Myelofibrosis

    Blood counts generally reveal normocytic, normochromic anemia, leukopenia, and thrombocytopenia.[symptoma.com] In case of hepatomegaly, the liver extends to more than 3 cm below the right costal margin of the newborn.[symptoma.com] Patients suffering from any infectious disease at the time of clinical examination may have fever.[symptoma.com]

  • Leukemia

    Patients with the BRAF V600E mutation had a significantly higher frequency of neutropenia, thrombocytopenia, and elevated soluble interleukin-2 receptor and common B-cell[ncbi.nlm.nih.gov] […] tiredness and fatigue Pain in bone Fever accompanied by chills Excessive sweating especially during night hours Easy prone to infections Bleeding or bruising very easily Hepatomegaly[symptoma.com] This phase of CML is characterized by fever, weakness, and an enlarged spleen.[britannica.com]

  • Primary Myelofibrosis

    Six weeks later, he developed grade 4 thrombocytopenia and grade 3 anemia.[ncbi.nlm.nih.gov] The patient, a 62-year-old female, having had primary myelofibrosis for 13 years and a splenectomy 4 years before, was admitted because of high fever, hepatomegaly, thrombocythemia[ncbi.nlm.nih.gov] Although ruxolitinib rapidly induced relief, he developed a high-grade fever. A comprehensive fever work-up found no apparent cause of the fever, except for PMF.[ncbi.nlm.nih.gov]

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