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1,316 Possible Causes for Fever, Hepatosplenomegaly, Seizure

  • Cryopyrin-Associated Periodic Syndrome

    Patients may have lymphadenopathy and/or hepatosplenomegaly. The CINCA/NOMID syndrome typically presents shortly after birth.[clevelandclinicmeded.com] Onset, severity and complications (mainly retardation, seizures, destructive arthropathy and amyloidosis) depend on the specific mutation.[ncbi.nlm.nih.gov] Herein, we present the case of a 9-month-old boy with recurrent nonpruritic rashes and episodes of fever.[ncbi.nlm.nih.gov]

  • CINCA Syndrome

    The patient was a male who was first seen at the age of 8-years for hepatosplenomegaly.[cags.org.ae] Headache, vomiting, altered mental state, intellectual disability, seizures, episodes of hemiplegia and chronic meningitis-like states are CNS manifestations of the disease[symptoma.com] The approach to a child with persistent fever is available .[pmmonlineindia.org]

  • Cytomegalovirus Infection

    […] should arouse suspicion of intrauterine CMV infection can be distinguished into CNS signs such as ventriculomegaly or microcephaly and extracerebral infection signs such as hepatosplenomegaly[ncbi.nlm.nih.gov] While receiving antiviral and corticosteroid therapy, the patient developed seizures related to a cerebral vasculitis.[ncbi.nlm.nih.gov] Abstract BACKGROUND: Coxiella burnetii is an obligate bacterial pathogen that causes Q fever.[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[ncbi.nlm.nih.gov] Extramedullary hematopoiesis may involve any organ and may result in gastrointestinal bleeding, spinal cord compression, seizures, haemoptysis, and/or effusions.[patient.info] Although ruxolitinib rapidly induced relief, he developed a high-grade fever. A comprehensive fever work-up found no apparent cause of the fever, except for PMF.[ncbi.nlm.nih.gov]

  • Systemic Lupus Erythematosus

    Partial or secondarily generalized seizures are most common, but all seizure types have been reported.[emedicine.medscape.com] PATIENT CONCERNS: The patient showed a high spiking fever and myalgia. Laboratory data revealed pancytopenia and immunological abnormalities.[ncbi.nlm.nih.gov] This FDG distribution pattern should be kept in mind when PET is performed for etiological investigation of fever of unknown origin.[ncbi.nlm.nih.gov]

  • B-Precursor Acute Lymphoblastic Leukemia

    Hepatosplenomegaly Enlarged lymph nodes A specific sign that constitutes a warning of a potentially aggressive and refractory disease is telangiectasias on the bulbar conjunctiva[symptoma.com] Major toxicities were grade 3 seizures in one patient and grade 3 cytokine release syndrome in 2 patients.[ncbi.nlm.nih.gov] Abstract We present the case of a 9-year-old girl from northwestern Greece admitted to our Hospital because of malaise, low-grade fever, intermittent hip joint pain, anemia[ncbi.nlm.nih.gov]

  • Familial Myelofibrosis

    The illness presented with pallor, haemorrhagic symptoms, and hepatosplenomegaly, and the blood picture was that of pancytopenia and leucoerythroblastosis.[ncbi.nlm.nih.gov] Patients suffering from any infectious disease at the time of clinical examination may have fever.[symptoma.com] Hepatosplenomegaly may cause irritability, feeding difficulties, loss of appetite and weight. Children may complain about abdominal pain.[symptoma.com]

  • Essential Thrombocythemia

    Ultrasound scan An ultra sound scan can be used to assess hepatosplenomegaly, which can then provide an indication of how far the disease has progressed.[aoporphan.com] Symptoms varied and included cerebral ischemic attacks, mental concentration disturbances followed by throbbing headaches, nausea, vomiting, syncope or even seizures.[ncbi.nlm.nih.gov] […] discomfort or feeling of fullness if the spleen or liver is enlarged tingling in the hands and feet sweating itchiness slightly higher than normal temperature (called a low-grade fever[cancer.ca]

  • Congenital Syphilis

    A previously healthy male infant developed hepatosplenomegaly, severe anaemia and thrombocytopenia 5 weeks after birth.[ncbi.nlm.nih.gov] […] characteristic skin lesions, lymphadenopathy, hepatosplenomegaly, failure to thrive, blood-stained nasal discharge, perioral fissures, meningitis, choroiditis, hydrocephalus, seizures[merckmanuals.com] Although rare, bow legs, recurrent fever, anemia, and inflammatory arthralgias may be manifestations of late CS.[ncbi.nlm.nih.gov]

  • Familial Hemophagocytic Lymphohistiocytosis

    Reported here is the case of a 12-year-old boy, from a poor family, with a 6-year history of visual loss and fever for 5 months, and transient hemiparesis with hepatosplenomegaly[ncbi.nlm.nih.gov] This disorder can affect multiple organ systems, and neurologic manifestations include irritability, seizures, impaired consciousness, meningismus, and cranial nerve palsies[ncbi.nlm.nih.gov] […] clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures[uniprot.org]

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