Fibrinogen Decreased: Causes & Reasons

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Possible Causes for Fibrinogen Decreased

Influenza

Excess mortality associated with annual influenza epidemics is highest among persons over 65 y of age, and therefore influenza is often regarded as an illness of the elderly population. Ample evidence indicates, however, that the burden of influenza is also substantial in children, and that children have a central[…] [ncbi.nlm.nih.gov]

Disseminated Intravascular Coagulation

Decreased in DIC May not be accurate in early disease because it is an acute phase reactant Clotting times and coagulation factors may be inaccurate in the presence of interfering [arupconsult.com]

[…] from Figure A 3 Increased PT and PTT, increased platelets and fibrinogen, smear from Figure B 4 Decreased PT and PTT, decreased platelets and fibrinogen, smear from Figure [medbullets.com]

An exception is in women with a retained dead fetus and evolving DIC with a progressive decrease in platelets, fibrinogen, and coagulation factors. [merckmanuals.com]

Liver Failure

[…] levels of coagulation factors: II, V, VII, IX, X, XI, quantitative and qualitative abnormalities of fibrinogen, low levels of α2-antiplasmin, Factor XIII and thrombin activatable [intechopen.com]

Hemostatic changes associated with thrombosis are elevated vWF, decreased levels of ADAMTS-13 (a vWF cleaving protease), and decreased levels of anti-coagulants: ATIII, Protein [intechopen.com]

[…] changes associated with surgical bleeding are thrombocytopenia, platelet function defects, inhibition of platelet aggregation and adhesion by nitric oxide and prostacyclin, decreased [intechopen.com]

Liver Metastasis

BACKGROUND: Liver metastasis is common in patients with colorectal cancer (CRC), and is correlated with poor outcome. MicroRNAs (miRNAs) are small non-coding RNAs involved in cancer development and progression, but their role in CRC liver metastasis has not been extensively investigated. RESULTS: Thirteen miRNAs[…] [ncbi.nlm.nih.gov]

Septicemia

Septicemia due to Pasteurella (Mannheimia) haemolytica is a rare occurrence. We report a fatal case of M. haemolytica septicemia in a seven-month-old infant who presented with prolonged fever, sepsis, and pneumonitis without discernable preceding history of animal bites or contact. Rare cases of systemic Mannheimia[…] [ncbi.nlm.nih.gov]

Cholestasis

Ann Hepatol. 2017 Nov;16(Suppl. 1: s3-105.):s53-s57. doi: 10.5604/01.3001.0010.5497. Author information 1 Departamento de Gastroenterología, Escuela de Medicina. Pontificia Universidad Católica de Chile. Santiago, Chile. 2 Departamento de Ciencias Químicas y Biológicas, Facultad de Salud, Universidad Bernardo O'Higgins,[…] [ncbi.nlm.nih.gov]

Metastatic Adenocarcinoma of the Breast

We report an exceptional case of metastatic adenocarcinoma of the breast occurring within a benign intradermal nevus. An extensive review of the literature on metastatic breast carcinoma is included. [ncbi.nlm.nih.gov]

Leukemia

What is leukemia? Leukemia is a cancer of the blood or blood cells. There are several types of leukemia. These are classified by how quickly they progress and what cell they affect. In order to understand how leukemia affects the cells, it is helpful to first understand what normal blood cells do. White blood cells[…] [es.oncolink.org]

Massive Hepatic Necrosis

[…] implies liver disease) Prothrombin time (factors V, VII, X, prothrombin, fibrinogen) (increase indicates liver disease) Markers for hepatocyte function (metabolism) Serum [quizlet.com]

[…] ammonia (increase indicates liver disease) Aminopyrine breath test (hepatic demethylation) (decrease implies liver disease) Galactose elimination (intravenous injection) [quizlet.com]

[…] transpeptidase (not as common) Serum 5'-nucleotidase (not as common) An elevation in these indicates liver damage Markers for hepatocyte function (blood) Serum albumin (decrease [quizlet.com]

Herpes Simplex Infection

Neonatal herpes is a potentially devastating consequence of perinatal transmission of the herpes simplex virus (HSV), with significant morbidity and mortality. Treatment options are available, but must begin early in disease with manifestations that are often protean. Thus, preventive measures need to be optimised.[…] [oadoi.org]

Hepatic Encephalopathy

Postoperative coma is not uncommon in patients after craniotomy. It generally presents as mental state changes and is usually caused by intracranial hematoma, brain edema, or swelling. Hyperammonemia can also result in postoperative coma; however, it is rarely recognized as a potential cause in coma patients.[…] [ncbi.nlm.nih.gov]

Waldenstrom Macroglobulinemia

After only 2 injections, CRP decreased from 100 mg/l to 20 mg/l, fibrinogen from 6 g/l to 3 g/l and ESR normalized at 40 mm/hr vs 120 mm/hr. [omicsonline.org]

Tocilizumab (Toci) introduced since the end of 2013 is still effective with CRP around 20 mg/L, fibrinogen under 4 g/l and ESR around 40 mm/hr. [omicsonline.org]

CRP decreased under 20 mg/l but prednisone was stopped because of side effects (osteoporosis, weight gain, etc.). Systemic inflammatory syndrome reappeared. [omicsonline.org]

Acute Myeloid Leukemia

Abstract Determining the percentage of peripheral blood (PB) and bone marrow (BM) blasts is important for diagnosing and classifying acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Although most patients with acute leukemia or MDS have a higher percentage of BM blasts than PB blasts, the[…] [dx.doi.org]

Traumatic Rhabdomyolysis

Abstract Thirty-one patients (26 males, 5 females) with mean age 35 /- 19 years (range 8 to 85 years) were diagnosed as non-traumatic rhabdomyolysis by clinical findings and elevation of serum creatine kinase (CK) between January 1989 and December 1993. Causes, laboratory measures, clinical courses, and outcome[…] [ncbi.nlm.nih.gov]

Primary Biliary Cirrhosis

Renal tubular acidosis (RTA) represents a class of metabolic disorders characterized by metabolic acidosis with a normal plasma anion gap. As a rare complication of primary biliary cirrhosis (PBC), RTA is easily overlooked, likely leading to misdiagnosis. A 32-year-old woman who had been diagnosed with PBC at our[…] [ncbi.nlm.nih.gov]

Chronic Myeloid Leukemia

Summary Epidemiology Its annual incidence has been estimated at between 1 and 1.5 cases per 100,000 and its prevalence at around 1 in 17,000. Clinical description The disease is typically triphasic with a chronic phase (CML-CP), accelerated phase (CML-AP) and blast phase (CML-BP). The majority of patients are[…] [orpha.net]

Acute Promyelocytic Leukemia

RESULTS: Prior to the treatment, the patients had elevated D-dimer and decreased fibrinogen levels. [ncbi.nlm.nih.gov]

Her fibrinogen was markedly decreased (62 mg/dL; lab normal range: 180-350 mg/dL). [austinpublishinggroup.com]

The D-dimer and prothrombin time were increased, and the patient's fibrinogen was decreased. Bone marrow and cytogenetic observations are shown in Table 2. [mlo-online.com]

Cerebral Thrombotic Thrombocytopenic Purpura

Characteristic laboratory findings include thrombocytopenia, decreased fibrinogen, increased prothrombin time, and abnormalities in tests for fibrinolysis. [ajnr.org]

Chronic Phase of Chronic Myeloid Leukemia

Int J Hematol. 2018 Mar;107(3):327-336. doi: 10.1007/s12185-017-2353-7. Epub 2017 Oct 26. Abstract In the ongoing, international, phase 3 study Evaluating Nilotinib Efficacy and Safety in Clinical Trials-Newly Diagnosed Patients (ENESTnd), nilotinib 300 and nilotinib 400 mg, both twice daily, are compared with imatinib 400 mg[…] [ncbi.nlm.nih.gov]

Hereditary Factor I Deficiency

[…] tests revealed a decreased functional fibrinogen level (family A). [pesquisa.bvsalud.org]

Upon fibrinogen substitution F1 2 decreased and were again increasing when fibrinogen concentration in plasma fell to very low levels. [ncbi.nlm.nih.gov]

[…] normal after fibrinogen infusion. [ncbi.nlm.nih.gov]

Hereditary Factor I Deficiency

Decreased clottable fibrinogen may be due to a quantitative deficiency, called hypofibrinogenemia, or a qualitative abnormality, known as dysfibrinogenemia. [clinlabnavigator.com]

[…] and a decrease in protein S Combined OCP OR: 3.5x higher HRT OR: 1.2x higher Heparin -induced thrombophilia Antibodies against platelet factor 4 ( PF-4 ) increased activation [amboss.com]

The Reptilase time is prolonged by decreased or dysfunctional fibrinogen, or high levels of fibrin degradation products (FDP). [mghlabtest.partners.org]

Marburg Virus Disease

[…] plasma fibrinogen and decreased fibrin deposition ( Bray et al., 2001 ; Geisbert and Hensley, 2004 ; Sanchez et al., 2007 ). [dmm.biologists.org]

[…] of the characteristics of DIC, which is a hallmark of filovirus infection in primates that includes prolongation of PT and aPTT, circulating fibrin degradation products, decreased [dmm.biologists.org]

Malaria

Dried leaf Artemisia annua (DLA) has shown efficacy against Plasmodium sp. in rodent studies and in small clinical trials. Rodent malaria also showed resiliency against the evolution of artemisinin drug resistance. This is a case report of a last resort treatment of patients with severe malaria who were responding[…] [ncbi.nlm.nih.gov]

Acute Monocytic Leukemia

Abstract Myeloid histocytes of dendritic cells (DCs), Langerhans cells (LCs), and macrophages in varied tissues, as leukemic blasts in acute monoblastic and monocytic leukemia (AML-M5a and M5b), are derived from monocyte progenitors in bone marrow. Based on DC induction from hematopoietic stem cells, myeloid[…] [ncbi.nlm.nih.gov]

Purpura Fulminans

At this point, the blood tests show an elevation in the international normalized ratio (INR; 2.65) and a decrease in fibrinogen (110.7 mg/dL [3.25 μmol/L]), and he receives [neoreviews.aappublications.org]

fibrinogen level. [ncbi.nlm.nih.gov]

Treatment with fresh-frozen plasma corrected the coagulation abnormalities, with a complete normalization of fibrinogen levels ( Fig. 3 ) and a marked decrease in D-dimer [doi.org]

Hemolytic Uremic Syndrome

Overhydration, hypertension, anemia, or dyselectrolytemias sometimes cause cardiovascular impairment in childhood hemolytic-uremic syndrome. Here, we report the case of a 4.5-year-old boy with hemolytic-uremic syndrome and sudden onset, 6 h later, of hemodynamic compromise secondary to a cardiac thrombotic[…] [ncbi.nlm.nih.gov]

Hydatidiform Mole

Hydatidiform mole with a coexistent fetus is rare, but this condition has recently shown an increased incidence because of assisted reproduction technology. Herein, we report on a case of triplet pregnancy with a partial hydatidiform mole coexisting with two fetuses. It was diagnosed by p57(kip2) immunohistochemical[…] [ncbi.nlm.nih.gov]

Thrombotic Thrombocytopenic Purpura

Summary Epidemiology The annual incidence estimates range from 1/250,000 to 1/1,000,000. The incidence in the U.K. is estimated at 1/166,000. Acquired TTP accounts for approximately 95% of all TTP cases. Clinical description Acquired TTP generally occurs in adulthood, whereas congenital TTP usually in the neonatal period[…] [orpha.net]

Coagulation Abnormalities

One of its leading symptoms is the decrease in circulating fibrinogen. [ncbi.nlm.nih.gov]

Approximately 37% CLD cases had decreased platelet count and 15% cases had decreased serum fibrinogen level. [ncbi.nlm.nih.gov]

Localized intravascular coagulation (LIC) was characterized by a decrease in fibrinogen (0.5-1 g/l), an increase in d-dimers (2-64 micro g/ml) and presence of soluble complex [ncbi.nlm.nih.gov]

Toxic Shock Syndrome

Staphylococcal toxic shock syndrome (TSS) has rarely been reported without rash and desquamation. This study describes a patient who met all criteria for TSS except erythroderma and desquamation. The associated staphylococcal superantigen was enterotoxin B. We demonstrate that erythroderma depends on[…] [ncbi.nlm.nih.gov]