Possible Causes for fibrinogen decreased Influenza Postgrad Med. 2018 Sep;130(7):650-651. doi: 10.1080/00325481.2018.1508984. Epub 2018 Aug 11. Author information 1 a Hospital General Universitario of Castellon, University of Valencia, Valencia, Spain. 2 b Hospital General Universitario of Castellon, Castellon de la Plana, Spain. 3 c Hospital of Virnaroz, Castellon, Spain.[…] [ncbi.nlm.nih.gov] Disseminated Intravascular Coagulation Decreased in DIC May not be accurate in early disease because it is an acute phase reactant Clotting times and coagulation factors may be inaccurate in the presence of interfering [arupconsult.com] […] from Figure A 3 Increased PT and PTT, increased platelets and fibrinogen, smear from Figure B 4 Decreased PT and PTT, decreased platelets and fibrinogen, smear from Figure [medbullets.com] An exception is in women with a retained dead fetus and evolving DIC with a progressive decrease in platelets, fibrinogen, and coagulation factors. [merckmanuals.com] Liver Failure […] levels of coagulation factors: II, V, VII, IX, X, XI, quantitative and qualitative abnormalities of fibrinogen, low levels of α2-antiplasmin, Factor XIII and thrombin activatable [intechopen.com] Hemostatic changes associated with thrombosis are elevated vWF, decreased levels of ADAMTS-13 (a vWF cleaving protease), and decreased levels of anti-coagulants: ATIII, Protein [intechopen.com] […] changes associated with surgical bleeding are thrombocytopenia, platelet function defects, inhibition of platelet aggregation and adhesion by nitric oxide and prostacyclin, decreased [intechopen.com] Liver Metastasis BACKGROUND: Liver metastasis is common in patients with colorectal cancer (CRC), and is correlated with poor outcome. MicroRNAs (miRNAs) are small non-coding RNAs involved in cancer development and progression, but their role in CRC liver metastasis has not been extensively investigated. RESULTS: Thirteen miRNAs[…] [ncbi.nlm.nih.gov] Septicemia Septicemia due to Pasteurella (Mannheimia) haemolytica is a rare occurrence. We report a fatal case of M. haemolytica septicemia in a seven-month-old infant who presented with prolonged fever, sepsis, and pneumonitis without discernable preceding history of animal bites or contact. Rare cases of systemic Mannheimia[…] [ncbi.nlm.nih.gov] Cholestasis Arch Toxicol. 2017 Aug;91(8):2879-2893. doi: 10.1007/s00204-017-1930-0. Epub 2017 Feb 10. Author information 1 KaLy-Cell, 20A rue du Général Leclerc, 67115, Plobsheim, France. 2 Novartis Institutes of Biomedical Research, Basel, Switzerland. 3 Centre Hospitalier de Mulhouse, 20 Avenue du Docteur René Laennec, 68100,[…] [ncbi.nlm.nih.gov] Metastatic Adenocarcinoma of the Breast We report an exceptional case of metastatic adenocarcinoma of the breast occurring within a benign intradermal nevus. An extensive review of the literature on metastatic breast carcinoma is included. [ncbi.nlm.nih.gov] Leukemia Greek : leukos white, aima blood Synonym : Leukaemia (BE) German : Leukämie Contents 1 Definition 2 History 3 Leukemia incidences 4 Leukemia classifiction 5 Symptoms 1 Definition Leukemia is a cancer of white blood cells ( Leukocytes ) or their precursors in the bone marrow. The disease is termed according to: (I)[…] [flexikon.doccheck.com] Massive Hepatic Necrosis […] implies liver disease) Prothrombin time (factors V, VII, X, prothrombin, fibrinogen) (increase indicates liver disease) Markers for hepatocyte function (metabolism) Serum [quizlet.com] […] ammonia (increase indicates liver disease) Aminopyrine breath test (hepatic demethylation) (decrease implies liver disease) Galactose elimination (intravenous injection) [quizlet.com] […] transpeptidase (not as common) Serum 5'-nucleotidase (not as common) An elevation in these indicates liver damage Markers for hepatocyte function (blood) Serum albumin (decrease [quizlet.com] Herpes Simplex Infection The acquisition of genital herpes during pregnancy has been associated with spontaneous abortion, prematurity, and congenital and neonatal herpes. The frequency of seroconversion, maternal symptoms of the disease, and the timing of its greatest effect on the outcome of pregnancy have not been systematically[…] [ncbi.nlm.nih.gov] Hepatic Encephalopathy BACKGROUND; Hepatic encephalopathy, both overt and minimal, forms a continuum of cognitive change in cirrhosis. Strategies to diagnose and treat hepatic encephalopathy have evolved considerably. To examine the updated diagnostic and treatment strategies for hepatic encephalopathy. Techniques for the clinical,[…] [ncbi.nlm.nih.gov] Waldenstrom Macroglobulinemia After only 2 injections, CRP decreased from 100 mg/l to 20 mg/l, fibrinogen from 6 g/l to 3 g/l and ESR normalized at 40 mm/hr vs 120 mm/hr. [omicsonline.org] Tocilizumab (Toci) introduced since the end of 2013 is still effective with CRP around 20 mg/L, fibrinogen under 4 g/l and ESR around 40 mm/hr. [omicsonline.org] CRP decreased under 20 mg/l but prednisone was stopped because of side effects (osteoporosis, weight gain, etc.). Systemic inflammatory syndrome reappeared. [omicsonline.org] Acute Myeloid Leukemia Induction therapy of acute myeloid leukemia (AML) with standard-dose chemotherapy will result in 52% to 72% of patients achieving a complete remission (CR) on bone marrow morphology. Newer agents that appear to improve the outcome of induction therapy are etoposide, idarubicin, and high-dose cytarabine. New[…] [ncbi.nlm.nih.gov] Traumatic Rhabdomyolysis • Following the collapse of a building, seven subjects (aged 18 to 41 years) were released from under the rubble within one to 28 hours. All seven suffered from extensive crush injuries with evidence of severe rhabdomyolysis and were treated by the induction of an alkaline solute diuresis immediately on their[…] [archinte.jamanetwork.com] Primary Biliary Cirrhosis A 34-year-old woman showed liver dysfunction for the first time at 3 months after delivery. Two years later, she was referred to our department with continued liver dysfunction. She fulfilled the criteria for primary biliary cirrhosis (PBC)-autoimmune hepatitis (AIH) overlap. Liver dysfunction improved after[…] [ncbi.nlm.nih.gov] Chronic Myeloid Leukemia To describe a rare case of an unusual visual threatening complication of chronic myeloid leukemia (CML). A 21-year-old male visited the hospital complaining of 1-week painless binocular acute visual loss without any other symptoms. The patient was diagnosed with CML. He then received emergent leukapheresis with[…] [ncbi.nlm.nih.gov] Acute Promyelocytic Leukemia RESULTS: Prior to the treatment, the patients had elevated D-dimer and decreased fibrinogen levels. [ncbi.nlm.nih.gov] Her fibrinogen was markedly decreased (62 mg/dL; lab normal range: 180-350 mg/dL). [austinpublishinggroup.com] The D-dimer and prothrombin time were increased, and the patient's fibrinogen was decreased. Bone marrow and cytogenetic observations are shown in Table 2. [mlo-online.com] Cerebral Thrombotic Thrombocytopenic Purpura Characteristic laboratory findings include thrombocytopenia, decreased fibrinogen, increased prothrombin time, and abnormalities in tests for fibrinolysis. [ajnr.org] Chronic Phase of Chronic Myeloid Leukemia Int J Hematol. 2018 Mar;107(3):327-336. doi: 10.1007/s12185-017-2353-7. Epub 2017 Oct 26. Abstract In the ongoing, international, phase 3 study Evaluating Nilotinib Efficacy and Safety in Clinical Trials-Newly Diagnosed Patients (ENESTnd), nilotinib 300 and nilotinib 400 mg, both twice daily, are compared with imatinib 400 mg[…] [ncbi.nlm.nih.gov] Hereditary Factor I Deficiency […] tests revealed a decreased functional fibrinogen level (family A). [pesquisa.bvsalud.org] Upon fibrinogen substitution F1 2 decreased and were again increasing when fibrinogen concentration in plasma fell to very low levels. [ncbi.nlm.nih.gov] […] normal after fibrinogen infusion. [ncbi.nlm.nih.gov] Hereditary Factor I Deficiency Decreased clottable fibrinogen may be due to a quantitative deficiency, called hypofibrinogenemia, or a qualitative abnormality, known as dysfibrinogenemia. [clinlabnavigator.com] […] and a decrease in protein S Combined OCP OR: 3.5x higher HRT OR: 1.2x higher Heparin -induced thrombophilia Antibodies against platelet factor 4 ( PF-4 ) increased activation [amboss.com] The Reptilase time is prolonged by decreased or dysfunctional fibrinogen, or high levels of fibrin degradation products (FDP). [mghlabtest.partners.org] Marburg Virus Disease […] plasma fibrinogen and decreased fibrin deposition ( Bray et al., 2001 ; Geisbert and Hensley, 2004 ; Sanchez et al., 2007 ). [dmm.biologists.org] […] of the characteristics of DIC, which is a hallmark of filovirus infection in primates that includes prolongation of PT and aPTT, circulating fibrin degradation products, decreased [dmm.biologists.org] Malaria Most pregnant women at risk of for infection with Plasmodium vivax live in the Asia-Pacific region. However, malaria in pregnancy is not recognised as a priority by many governments, policy makers, and donors in this region. Robust data for the true burden of malaria throughout pregnancy are scarce. Nevertheless,[…] [ncbi.nlm.nih.gov] Acute Monocytic Leukemia Abstract Myeloid histocytes of dendritic cells (DCs), Langerhans cells (LCs), and macrophages in varied tissues, as leukemic blasts in acute monoblastic and monocytic leukemia (AML-M5a and M5b), are derived from monocyte progenitors in bone marrow. Based on DC induction from hematopoietic stem cells, myeloid[…] [ncbi.nlm.nih.gov] Hemolytic Uremic Syndrome Int J Infect Dis. 2015 May;34:119-21. doi: 10.1016/j.ijid.2015.03.024. Epub 2015 Apr 2. Author information 1 Department of Obstetrics and Gynecology, University of Toyama, Toyama-shi, Toyama 930-0194, Japan. 2 Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa[…] [ncbi.nlm.nih.gov] Purpura Fulminans At this point, the blood tests show an elevation in the international normalized ratio (INR; 2.65) and a decrease in fibrinogen (110.7 mg/dL [3.25 μmol/L]), and he receives [neoreviews.aappublications.org] fibrinogen level. [ncbi.nlm.nih.gov] Treatment with fresh-frozen plasma corrected the coagulation abnormalities, with a complete normalization of fibrinogen levels ( Fig. 3 ) and a marked decrease in D-dimer [doi.org] Hydatidiform Mole Distinction of hydatidiform moles from nonmolar specimens and their subclassification as complete (complete hydatidiform mole) versus partial hydatidiform mole (PHM) are important for clinical practice and investigational studies to refine ascertainment of risk of persistent gestational trophoblastic disease, which[…] [ncbi.nlm.nih.gov] Thrombotic Thrombocytopenic Purpura Plasma exchange is the principal treatment for acquired thrombotic thrombocytopenic purpura (TTP) but is invasive and may have adverse effects. Reports of immunoglobulin therapy for acquired TTP without plasma exchange are rare. A 14-year-old girl was admitted because of hemolytic anemia and thrombocytopenia.[…] [ncbi.nlm.nih.gov] Coagulation Abnormalities One of its leading symptoms is the decrease in circulating fibrinogen. [ncbi.nlm.nih.gov] Approximately 37% CLD cases had decreased platelet count and 15% cases had decreased serum fibrinogen level. [ncbi.nlm.nih.gov] Localized intravascular coagulation (LIC) was characterized by a decrease in fibrinogen (0.5-1 g/l), an increase in d-dimers (2-64 micro g/ml) and presence of soluble complex [ncbi.nlm.nih.gov] Toxic Shock Syndrome Abstract The aim of this study was to examine the production of superantigenic toxins in vivo and in vitro in two patients with streptococcal toxic shock syndrome (TSS). In the first patient, a woman with puerperal fever and Streptococcus pyogenes peritonitis, flow cytometry of blood cells and in vitro studies of[…] [ncbi.nlm.nih.gov]
