Fibrinogen Decreased: Causes & Reasons

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Possible Causes for Fibrinogen Decreased

Disseminated Intravascular Coagulation

Decreased in DIC May not be accurate in early disease because it is an acute phase reactant Clotting times and coagulation factors may be inaccurate in the presence of interfering [arupconsult.com]

[…] from Figure A 3 Increased PT and PTT, increased platelets and fibrinogen, smear from Figure B 4 Decreased PT and PTT, decreased platelets and fibrinogen, smear from Figure [medbullets.com]

[…] platelets increased PT, PTT, and thrombin time increased LDH decreased fibrinogen D-dimer schistocytes on peripheral smear return to top Differential Diagnosis return to [sharinginhealth.ca]

Hereditary Factor I Deficiency

Decreased clottable fibrinogen may be due to a quantitative deficiency, called hypofibrinogenemia, or a qualitative abnormality, known as dysfibrinogenemia. [clinlabnavigator.com]

[…] and a decrease in protein S Combined OCP OR: ∼ 3.5x higher HRT OR: ∼ 1.2x higher Heparin -induced thrombophilia Antibodies against platelet factor 4 ( PF-4 ) → increased [amboss.com]

The Reptilase® time is prolonged by decreased or dysfunctional fibrinogen, or high levels of fibrin degradation products (FDP). [mghlabtest.partners.org]

Hereditary Factor I Deficiency

[…] tests revealed a decreased functional fibrinogen level (family A). [pesquisa.bvsalud.org]

[…] normal after fibrinogen infusion. [ncbi.nlm.nih.gov]

FXIII activity levels then decreased until D10 in parallel to the fibrinogen concentration. [haematologica.org]

Purpura Fulminans

At this point, the blood tests show an elevation in the international normalized ratio (INR; 2.65) and a decrease in fibrinogen (110.7 mg/dL [3.25 μmol/L]), and he receives [neoreviews.aappublications.org]

fibrinogen level. [ncbi.nlm.nih.gov]

Treatment with fresh-frozen plasma corrected the coagulation abnormalities, with a complete normalization of fibrinogen levels ( Fig. 3 ) and a marked decrease in D-dimer [doi.org]

Acute Promyelocytic Leukemia

RESULTS: Prior to the treatment, the patients had elevated D-dimer and decreased fibrinogen levels. [ncbi.nlm.nih.gov]

Her fibrinogen was markedly decreased (62 mg/dL; lab normal range: 180-350 mg/dL). [austinpublishinggroup.com]

The D-dimer and prothrombin time were increased, and the patient's fibrinogen was decreased. Bone marrow and cytogenetic observations are shown in Table 2. [mlo-online.com]

Liver Failure

[…] levels of coagulation factors: II, V, VII, IX, X, XI, quantitative and qualitative abnormalities of fibrinogen, low levels of α2-antiplasmin, Factor XIII and thrombin activatable [intechopen.com]

Hemostatic changes associated with thrombosis are elevated vWF, decreased levels of ADAMTS-13 (a vWF cleaving protease), and decreased levels of anti-coagulants: ATIII, Protein [intechopen.com]

[…] changes associated with surgical bleeding are thrombocytopenia, platelet function defects, inhibition of platelet aggregation and adhesion by nitric oxide and prostacyclin, decreased [intechopen.com]

Amniotic Fluid Embolism

Coagulation tests, including those for FDP, D-dimer, and fibrinogen, showed that fibrinogen had decreased to 1. [jaclinicalreports.springeropen.com]

If AFE is suspected, fibrinogen level should be measured rapidly for favoring a more AFE to decrease the risk of death from AFE. [ncbi.nlm.nih.gov]

Interestingly, both serum FDP and D-dimer decreased promptly after administration of fibrinogen and antithrombin concentrate. [jaclinicalreports.springeropen.com]

Massive Hepatic Necrosis

[…] implies liver disease) Prothrombin time (factors V, VII, X, prothrombin, fibrinogen) (increase indicates liver disease) Markers for hepatocyte function (metabolism) Serum [quizlet.com]

[…] ammonia (increase indicates liver disease) Aminopyrine breath test (hepatic demethylation) (decrease implies liver disease) Galactose elimination (intravenous injection) [quizlet.com]

[…] transpeptidase (not as common) Serum 5'-nucleotidase (not as common) An elevation in these indicates liver damage Markers for hepatocyte function (blood) Serum albumin (decrease [quizlet.com]

Cerebral Thrombotic Thrombocytopenic Purpura

Characteristic laboratory findings include thrombocytopenia, decreased fibrinogen, increased prothrombin time, and abnormalities in tests for fibrinolysis. [ajnr.org]

Waldenstrom Macroglobulinemia

After only 2 injections, CRP decreased from 100 mg/l to 20 mg/l, fibrinogen from 6 g/l to 3 g/l and ESR normalized at 40 mm/hr vs 120 mm/hr. [omicsonline.org]

Waldenström (1906–1996) in 1944 in two patients with bleeding from the nose and mouth, anemia, decreased levels of fibrinogen in the blood (hypofibrinogenemia), swollen lymph [en.wikipedia.org]

Tocilizumab (Toci) introduced since the end of 2013 is still effective with CRP around 20 mg/L, fibrinogen under 4 g/l and ESR around 40 mm/hr. [omicsonline.org]

Marburg Virus Disease

[…] plasma fibrinogen and decreased fibrin deposition ( Bray et al., 2001 ; Geisbert and Hensley, 2004 ; Sanchez et al., 2007 ). [dmm.biologists.org]

[…] of the characteristics of DIC, which is a hallmark of filovirus infection in primates that includes prolongation of PT and aPTT, circulating fibrin degradation products, decreased [dmm.biologists.org]

Dengue Hemorrhagic Fever

Prolongations of activated partial thromboplastin time and prothrombin time and decreases of platelet counts, fibrinogen, prothrombin, factor VIII, plasminogen and antithrombin [karger.com]

It was also found that a2 antiplasmin was decreased in the acute stage to 32 % of the normal level on the average. [karger.com]

Influenza

OBJECTIVE: To determine the clinical effectiveness of influenza vaccination in patients with rheumatoid arthritis (RA). METHODS: The present study was conducted by using the Taiwan National Health Insurance Research Database. In this retrospective nationwide study, we included 3748 RA patients who received[…] [ncbi.nlm.nih.gov]

Liver Metastasis

BACKGROUND: Liver metastasis is common in patients with colorectal cancer (CRC), and is correlated with poor outcome. MicroRNAs (miRNAs) are small non-coding RNAs involved in cancer development and progression, but their role in CRC liver metastasis has not been extensively investigated. RESULTS: Thirteen miRNAs[…] [ncbi.nlm.nih.gov]

Septicemia

Septicemia due to Pasteurella (Mannheimia) haemolytica is a rare occurrence. We report a fatal case of M. haemolytica septicemia in a seven-month-old infant who presented with prolonged fever, sepsis, and pneumonitis without discernable preceding history of animal bites or contact. Rare cases of systemic Mannheimia[…] [ncbi.nlm.nih.gov]

Cholestasis

Cholestasis Micrograph showing bile (yellow) stasis, i.e. cholestasis. H&E stain. Specialty Gastroenterology Cholestasis is a condition where bile cannot flow from the liver to the duodenum. The two basic distinctions are an obstructive type of cholestasis where there is a mechanical blockage in the duct system that[…] [en.wikipedia.org]

Metastatic Adenocarcinoma of the Breast

We report an exceptional case of metastatic adenocarcinoma of the breast occurring within a benign intradermal nevus. An extensive review of the literature on metastatic breast carcinoma is included. [ncbi.nlm.nih.gov]

Leukemia

Leukemia is a type of blood cancer that begins in the bone marrow. Bone marrow is the soft tissue in the center of the bones, where blood cells are produced. The term leukemia means white blood. White blood cells (leukocytes) are used by the body to fight infections and other foreign substances. Leukocytes are[…] [nlm.nih.gov]

Herpes Simplex Infection

Herpes simplex infection is a term encompassing a wide range of infections that can be caused by herpes simplex viruses (HSV-1 and HSV-2). Mucocutaneous, oropharyngeal, genital, central nervous system, disseminated and systemic forms have been identified in children, adults, pregnant women, and neonates. An early[…] [symptoma.com]

Hepatic Encephalopathy

Hepatic encephalopathy Other names Portosystemic encephalopathy, hepatic coma,[1] coma hepaticum Micrograph of Alzheimer type II astrocytes, as may be seen in hepatic encephalopathy. Specialty Gastroenterology Symptoms Altered level of consciousness, mood changes, personality changes, movement problems[2] Types[…] [en.wikipedia.org]

Acute Myeloid Leukemia

History Patients with acute myeloid leukemia (AML) present with signs and symptoms resulting from bone marrow failure, organ infiltration with leukemic cells, or both. The time course is variable. Some patients, particularly younger ones, present with acute symptoms that develop over a few days to 1-2 weeks. Others[…] [emedicine.medscape.com]

Traumatic Rhabdomyolysis

Leg Med (Tokyo). 2016 May;20:40-3. doi: 10.1016/j.legalmed.2016.04.001. Epub 2016 Apr 13. Chiba F 1, Makino Y 2, Motomura A 3, Inokuchi G 3, Ishii N 3, Torimitsu S 3, Hoshioka Y 3, Abe H 3, Yamaguchi R 2, Hashimoto M 2, Sakuma A 3, Nagasawa S 3, Saito H 3, Yajima D 3, Iwase H 2. Author information 1 Department of Forensic[…] [ncbi.nlm.nih.gov]

Primary Biliary Cirrhosis

Primary biliary cholangitis Other names Primary biliary cirrhosis Micrograph of PBC showing bile duct inflammation and injury. H&E stain. Specialty Gastroenterology Symptoms Cholestasis, pruritus, fatigue Complications Cirrhosis, hepatic failure, portal hypertension Usual onset Usually middle-aged women Causes Autoimmune[…] [en.wikipedia.org]

Chronic Myeloid Leukemia

Summary Epidemiology Its annual incidence has been estimated at between 1 and 1.5 cases per 100,000 and its prevalence at around 1 in 17,000. Clinical description The disease is typically triphasic with a chronic phase (CML-CP), accelerated phase (CML-AP) and blast phase (CML-BP). The majority of patients are[…] [orpha.net]

Chronic Phase of Chronic Myeloid Leukemia

Shima H 1, 2, Kiyokawa N 3, Miharu M 3, Tanizawa A 4, Kurosawa H 5, Watanabe A 6, Ito M 7, Tono C 8, Yuza Y 9, Muramatsu H 10, Hotta N 11, Okada M 12, Hamamoto K 13, Kajiwara R 14, Saito AM 2, Horibe K 2, Mizutani S 15, Adachi S 16, Ishii E 17, Shimada H 1. Author information 1 Department of Pediatrics, Keio University[…] [ncbi.nlm.nih.gov]

Malaria

Malaria is a major cause of death worldwide and is brought about by the protozoan parasite Plasmodium acquired from a bite of a female Anopheles mosquito carrier. Malaria are still endemic in warm climates and in most third world countries around the globe. It is essentially non-existent in highly developed and first[…] [symptoma.com]

Acute Monocytic Leukemia

Human leukemia cell lines are of great value in investigating basic and applied aspects of cell biology and clinical medicine. There have been 37 leukemia cell lines carrying 11q23 translocation and MLL rearrangements; however, cell lines harboring with t(1;11)(p32;q23) have not been established. We report here for the[…] [ncbi.nlm.nih.gov]

Hemolytic Uremic Syndrome

Hemolytic-uremic syndrome (HUS) is a group of blood disorders characterized by low red blood cells, acute kidney failure, and low platelets. Initial symptoms typically include bloody diarrhea, fever, vomiting, and weakness. Kidney problems and low platelets then occur as the diarrhea is improving. While children are more[…] [en.wikipedia.org]

Hydatidiform Mole

Hydatidiform mole co-existing with a normal fetus is very rare. We report a case of a 36 year old woman Para 4+0 who presented with amenorrhoea of twenty four weeks duration, vaginal bleeding, abdominal pain and pre-eclampsia. Ultrasound examination revealed a hydatidiform mole coexisting with a normal living fetus.[…] [ncbi.nlm.nih.gov]

Thrombotic Thrombocytopenic Purpura

Thrombotic thrombocytopenic purpura (TTP) is a blood disorder that results in blood clots forming in small blood vessels throughout the body. This results in a low platelet count, low red blood cells due to their breakdown, and often kidneys, heart, and brain dysfunction. Symptoms may include large bruises, fever,[…] [en.wikipedia.org]