Fibrinoid necrosis is a form of necrosis, or tissue death, in which there is accumulation of amorphous, basic, proteinaceous material in the tissue matrix with a staining pattern reminiscent of fibrin. It is associated with conditions such as immune vasculitis (e.g. polyarteritis nodosa), malign...
Most common diseases
Systemic Lupus Erythematosus
necrosis at dermoepidermal junction with liquefactive degeneration and atrophy of epidermis More mucin deposition in reticular dermis than discoid lupus Edema, small hemorrhages [pathologyoutlines.com]
Pathological studies demonstrate infarction of the optic nerve secondary to extensive arteriolar fibrinoid necrosis [ 35 ]. [academic.oup.com]
[…] degeneration and necrosis. [doi.org]
Rheumatoid Nodule
Adjacent vessels showed inflammation and fibrinoid necrosis of their walls suggestive of a vasculitis. [ncbi.nlm.nih.gov]
The characteristic morphological finding of the granulomas was the presence of neutrophils and the absence of definite fibrinoid necrosis, which differed from the typical [ncbi.nlm.nih.gov]
On microscopic examination, the lesion consisted of two distinct areas: a central area of fibrinoid necrosis, bordered by histiocytes in a palisaded arrangement, lymphocytes [ncbi.nlm.nih.gov]
Cutaneous Leukocytoclastic Vasculitis
necrosis, epidermal necrosis and fibrin thrombi. [ncbi.nlm.nih.gov]
(b) H and E stained section of a skin biopsy showing perivascular infiltration of inflammatory cells, resulting in fibrinoid necrosis ( 100) Click here to view There have [e-ijd.org]
(A) Skin biopsy demonstrating a predominant neutrophilic infiltration, presence of eosinophils, leukocytoclasia and fibrinoid necrosis around the dermal superficial, vessel [pubs.sciepub.com]
Vasculitis
NECROSIS H&E stain Eosinophilic, homogenous, & refractile staining in inner regions of vessel wall Endothelial components Can be seen inside the layer of fibrinoid necrosis [neuromuscular.wustl.edu]
necrosis of vessel walls Variable secondary changes in overlying epidermis and sweat glands Microscopic (histologic) images Contributed by Mark R. [pathologyoutlines.com]
Visible are numerous neutrophils with leukocytoclasis and fibrinoid necrosis of small vessel walls. [rheumatologyadvisor.com]
Renal Vasculitis
necrosis of arteries. [ncbi.nlm.nih.gov]
There was a significant decrease in the percentage of acute lesions (cellular crescents, fibrinoid necrosis, P 0.001) and a significant increase in chronic lesions (glomerulosclerosis [ncbi.nlm.nih.gov]
Segmental fibrinoid necrosis, an absence of immune deposits in the glomeruli (as seen in pauci-immune glomerulonephritis), and the presence of glomerular crescents are frequently [symptoma.com]
Benign Arteriolar Nephrosclerosis
Pathology Fibrinoid necrosis of small arteries (necrotising arteriolitis); intimal hyperplasia of larger interlobular arteries (hyperplastic arteriolitis); “onion-skinning [medical-dictionary.thefreedictionary.com]
Fibrinoid necrosis of small arteries & arterioles especially at the branching point of an afferent arterioles & where it enters the glomerulus. [pathology.class.kmu.edu.tw]
• Fibrinoid necrosis of arterioles accompanied by an inflammatory infiltrate resulting in necrotising alveolitis and hyperplastic arteriolitis, with onionskin-like layering [medical-dictionary.thefreedictionary.com]
Malignant Nephrosclerosis
Immunofluorescence revealed similar deposits of immunoglobulins and fibrinogen in the site of fibrinoid necrosis observed in both groups. [ncbi.nlm.nih.gov]
[…] hyperplasia of somewhat longer duration, whereas in the exacerbated form coexistence of vascular lesions of various intensities and durations, acute (fibrinoid necrosis and [ncbi.nlm.nih.gov]
[…] walls and small crescents Myointimal hyperplasia and hypertropy is associated with acute or persistent severe high blood pressure Necrotizing arteriolitis: fibrinoid necrosis [pathologyoutlines.com]
Cerebral Angiitis
Multinucleated giant cells forming granulomas, fibrinoid necrosis, or both are variably present. [ahajournals.org]
No thrombosis or fibrinoid necrosis is identified. The lymphocytes appear small and mature and they do not show any nuclear atypia. [radiopaedia.org]
Architectural disruption of amyloid-β laden vessels, occasionally with fibrinoid necrosis, leads to perivascular leakage. [ahajournals.org]
Necrotizing Arteritis
Endothelial injury and medial degeneration, followed by fibrinoid necrosis, occurred in the acute stage, and regression of fibrinoid necrosis and fibrosis were present in [ncbi.nlm.nih.gov]
Vascular changes in both cases were similar to those seen in classic polyarteritis nodosa, involving medium-sized muscular arteries characterized by fibrinoid necrosis and [ncbi.nlm.nih.gov]
Fibrinoid necrosis was rare, observed in 2 specimens; 2 patients with unclassified systemic vasculitis and WG had a classic giant cell arteritis (GCA) histologic pattern. [ncbi.nlm.nih.gov]
Polyarteritis Nodosa
The swelling histopathologically showed necrotizing inflammation, fibrinoid necrosis of the medium-sized arteries of the epididymis and was diagnosed to be single organ variant [ncbi.nlm.nih.gov]
On review, the biopsy revealed features of necrotizing arteritis as seen in PAN with fibrinoid necrosis and giant cells, thus highlighting the fact that vasculitis due to [ncbi.nlm.nih.gov]
Differential diagnosis Kawasaki's disease : more mural edema and infiltrating monocytes, less fibrinoid necrosis Back to top [pathologyoutlines.com]