Fibrosis: Causes & Reasons

Possible Causes for Fibrosis

Look For Subscription Required Diagnostic Pearls Subscription Required Differential Diagnosis & Pitfalls Shwachman-Diamond syndrome Isolated pancreatic insufficiency Cystic fibrosis [visualdx.com]

Differential diagnosis Differential diagnosis includes cystic fibrosis, Shwachman-Diamond syndrome, Pearson Marrow-Pancreas syndrome, partial pancreatic agenesis (for congenital [orpha.net]

Joseph's Medical Center, Paterson, NJ Free Genetic causes of exocrine pancreatic insufficiency (EPI) are rare and commonly associated with Cystic fibrosis (CF) or Shwachman [journals.lww.com]

Sinusitis

The Sinuses in Cystic Fibrosis The sinuses are a group of 4 pairs of air filled spaces in the head. [web.stanford.edu]

Cystic fibrosis (CF) is the most frequent congenital lethal disease in Caucasians. [mdpi.com]

Sinus disease in cystic fibrosis. Clinical Reviews in Allergy and Immunology 21: 51- 63, 2001. [web.stanford.edu]

Pseudomonas

Cystic fibrosis environment genotyping Pseudomonas aeruginosa The major pulmonary pathogen in patients with cystic fibrosis (CF) is Pseudomonas aeruginosa. [erj.ersjournals.com]

European Cystic Fibrosis Society. [journals.sagepub.com]

People with cystic fibrosis are particularly susceptible to chest infections, some of which can become chronic. [cochrane.org]

Pseudomonas Aeruginosa

Cystic Fibrosis 4,49–54 ( 2005 ). [doi.org]

Pseudomonas aeruginosa is a pathogen associated with cystic fibrosis that has potential to decrease lung function and cause respiratory failure. [ncbi.nlm.nih.gov]

The persistence of chronic Pseudomonas aeruginosa lung infections in cystic fibrosis (CF) patients is due to biofilm-growing mucoid (alginate-producing) strains. [ncbi.nlm.nih.gov]

Nasal Polyp

Nasal polyps are common in people with cystic fibrosis, affecting between 10 to 50 percent. [cysticfibrosis.ca]

Nasal polyps can be allergic (adult) or cystic fibrosis (children)...Nasal Polyps usually arise after a chronic inflammation of the nasal cavity or paranasal sinuses. [youtube.com]

Atelectasis

Recombinant human deoxyribonuclease (rhDNase) reduces sputum viscosity and improves pulmonary function in cystic fibrosis (CF). [ncbi.nlm.nih.gov]

Mucus plugs are also common in children, people with cystic fibrosis and during severe asthma attacks. Foreign body. [mayoclinic.org]

N -acetylcysteine aerosols for clearance of tenacious secretions DNase has proved to be beneficial for infectious atelectasis in paediatric patients with noncystic fibrosis [respiratoryupdates.wordpress.com]

Pulmonary Emphysema

Clinical features and outcomes in combined pulmonary fibrosis and emphysema in idiopathic pulmonary fibrosis. [journal.copdfoundation.org]

Combined pulmonary fibrosis and emphysema (CPFE): an entity different from emphysema or pulmonary fibrosis alone. [jtd.amegroups.com]

The coexistence of emphysema and fibrosis makes the estimation of the extent of fibrosis really difficult. [copdrp.biomedcentral.com]

Liver Cirrhosis

The Congestive Hepatic Fibrosis score is another example where stage 1 refers to zone 3 fibrosis [ 14 ]. [ncbi.nlm.nih.gov]

Regression of liver fibrosis. Semin Liver Dis. 2017;37(1):1–10. PubMed CrossRef Google Scholar 8. [dx.doi.org]

HISTOLOGICAL ASSESSMENT OF FIBROSIS/CIRRHOSIS REGRESSION In practice, regression of fibrosis is defined as the decrease in fibrosis score in paired consecutive biopsies, whichever [ncbi.nlm.nih.gov]

Cor Pulmonale

Idiopathic pulmonary fibrosis (IPF) is a rarely reported disease in Nigeria. [ncbi.nlm.nih.gov]

A pulmonary biopsy revealed fibrosis of about 40% of the parenchyma. [beva.onlinelibrary.wiley.com]

Cor pulmonale secondary to pulmonary fibrosis in a 16‐year‐old mare First published: 23 August 2018 Summary A 16‐year‐old mare was presented as an emergency to the Equine [onlinelibrary.wiley.com]

Chronic Sinusitis

Cystic fibrosis is a lethal genetic disorder whose victims currently have a median life span of approximately 30 years. [ncbi.nlm.nih.gov]

OBJECTIVE: To assess the association between pathogenic bacteria found in bronchoalveolar lavages and paranasal cavity cultures in patients with cystic fibrosis (CF) who underwent [ncbi.nlm.nih.gov]

Chronic sinusitis is universal in cystic fibrosis (CF) and our current treatments are ineffective in reversing sinus disease. [ncbi.nlm.nih.gov]

Cholestatic Jaundice

BACKGROUND: Obstructive jaundice has been reported to influence liver elasticity, independent of liver fibrosis. [ncbi.nlm.nih.gov]

Endoscopic ultrasound biopsy found pancreatic tissue with lymphoplasmacytic inflammation and fibrosis. IgG4 serum concentration was within normal range. [ncbi.nlm.nih.gov]

Alcohol and Drugs Leads to hepatitis (liver inflammation) and cirrhosis (fibrosis of liver tissue). [healthhype.com]

Portal Cirrhosis

Hepatic fibrosis stage 3 Hepatic fibrosis w hepatic sclerosis Hepatic fibrosis with hepatic sclerosis Hepatic fibrosis, stage 3 Hypoxia-associated cirrhosis Indian childhood [icd9data.com]

Convert to ICD-10-CM: 571.5 converts approximately to: 2015/16 ICD-10-CM K74.0 Hepatic fibrosis Or: 2015/16 ICD-10-CM K74.60 Unspecified cirrhosis of liver Or: 2015/16 ICD [icd9data.com]

[…] caused by hepatic fibrosis [ 3 ]. [journals.plos.org]

Hemochromatosis

METHODS: Liver fibrosis was histologically assessed by Ishak score. [ncbi.nlm.nih.gov]

BACKGROUND AND AIMS: In hereditary hemochromatosis, iron deposition in the liver parenchyma may lead to fibrosis, cirrhosis and hepatocellular carcinoma. [ncbi.nlm.nih.gov]

In addition, the effect of the SNP on liver fibrosis was examined comparing patients with absent/mild-moderate fibrosis to those with severe fibrosis-cirrhosis. [ncbi.nlm.nih.gov]

Hypertrophic Cardiomyopathy

MRI assessment showed that fibrosis was classified as endocardial, epicardial, or whole-layer (= either or both of these). [ncbi.nlm.nih.gov]

[…] and prevalence of fibrosis on right ventricular (RV)-LV insertions, a higher LA volume and lower LA phasic function. [ncbi.nlm.nih.gov]

Hypertensive Heart Disease

Abstract Myocardial fibrosis is commonly observed in left ventricular (LV) hypertrophied heart during Arterial Hypertension. [ncbi.nlm.nih.gov]

The extensive distribution of fibrosis involving the right and left heart suggests cardiomyocyte necrosis is widespread. [ncbi.nlm.nih.gov]

Abstract Established cardiac fibrosis (ECF) with symptomatic heart failure preserved ejection fraction represents an ever-increasing segment of the hypertensive population [ncbi.nlm.nih.gov]

Alcoholic Liver Disease

AIM: To assess liver fibrosis (LF) in hepatitis C virus (HCV) and alcoholic liver disease (ALD), estimate health outcomes and costs of new noninvasive testing strategies. [ncbi.nlm.nih.gov]

Light microscopy of the liver biopsy specimen revealed parenchymal fat with portal and perisinusoidal fibrosis. [ncbi.nlm.nih.gov]

Hepatic stellate cells play an important role in angiogenesis and liver fibrosis. Anti-angiogenic therapy has been found to be effective in the prevention of fibrosis. [ncbi.nlm.nih.gov]

Recurrent Acute Pancreatitis

[…] in patients with cystic fibrosis. [ncbi.nlm.nih.gov]

We present the case of a young woman previously diagnosed with cystic fibrosis (CF) manifested primarily by respiratory symptoms and pancreatic exocrine insufficiency. [ncbi.nlm.nih.gov]

Mutations in the gene encoding the cystic fibrosis transmembrane regulator (CFTR) have been reported to increase the risk of recurrent acute pancreatitis in patients with [ncbi.nlm.nih.gov]

Lipedema

Lipedema fibrosis can be further complicated by other types of fibrosis such as surgical scar tissue, radiation-induced fibrosis, post-cellulitis fibrosis, or lipodermatosclerosis [lymphaticnetwork.org]

This helps relieve pain and prevent fibrosis. Continued Compression. [webmd.com]

Sometimes called the spontaneously irreversible stage, stage 2 is identified mainly from tissue proliferation and subsequent fibrosis (called lymphostatic fibrosis). [woundcareadvisor.com]

Peritoneal Fibrosis

Myofibroblastic differentiation and epithelial-to-mesenchymal transition were common findings in all situations of peritoneal fibrosis. [ncbi.nlm.nih.gov]

[…] in the peritoneal fibrosis. [ncbi.nlm.nih.gov]

and there are also reports indicating the involvement of some RTKs in peritoneal fibrosis. [ncbi.nlm.nih.gov]

Pancreatitis

The pancreas in cystic fibrosis. In: Davis PB, ed. Cystic Fibrosis. [pediatrics.aappublications.org]

Evidence suggests that some cases of unidentified chronic pancreatitis may be associated with atypical mutations of cystic fibrosis genes. [columbiasurgery.org]

↵ Cystic Fibrosis Genotype-Phenotype Consortium. Correlation between genotype and phenotype in patients with cystic fibrosis. [pediatrics.aappublications.org]

Colitis Cystica Profunda

Histologic examination of snare biopsies identified dilated glands with mucinous content, surrounded by variable degrees of fibrosis on a background of interspersed chronic [acgcasereports.gi.org]

COMPLICATION IATROGENE RADIOTHERAPIE PATHOLOGIE DIGESTIVE GASTROENTEROLOGIE RODENTIA MAMMALIA VERTEBRATA Keyword (en) RADIATION INJURY RECTUM EXPERIMENTAL DISEASE PATHOLOGY FIBROSIS [pascal-francis.inist.fr]

Transrectal ultrasonography identifies multiple cysts in the rectal submucosa, with areas of echorefringent fibrosis between cysts, and confirms the absence of lymph node [ncbi.nlm.nih.gov]

Macronodular Cirrhosis

Cirrhosis Pathology A key ingredient is fibrosis, whose development and extent depends upon the interplay of many factors. [hepatitiscentral.com]

In this system, fibrosis is categorized into five stages: no fibrosis (F0), zone 3 perisinusoidal fibrosis (F1), zone 3 perisinusoidal fibrosis plus zone 1 periportal fibrosis [pubs.rsna.org]

Next Steps Evidence Creator Insights Advice Low fibrosis scores may be appropriate candidates for medical management and may not require liver biopsy if FIB-4 scores continue [mdcalc.com]

Acute Interstitial Nephritis

Delayed steroid treatment, when interstitial fibrosis has taken place, would have a less pronounced or nule therapeutic benefit. [ncbi.nlm.nih.gov]

Collectively, WNT10A may induce kidney fibrosis and associate with kidney dysfunction in AIN. [ncbi.nlm.nih.gov]

An ultrasound showing small kidneys usually indicates advanced fibrosis and unlikely benefit from corticosteroid use. [cjasn.asnjournals.org]

Cryptogenic Cirrhosis

Fibrosis stage and HAI are generally stable after transplantation for cryptogenic cirrhosis. [ncbi.nlm.nih.gov]

The histological NAFLD activity score and the NAFLD fibrosis score (NFS) were assessed. [ncbi.nlm.nih.gov]

Serial liver biopsy samples were assessed for steatosis and fibrosis. [ncbi.nlm.nih.gov]

Hereditary North American Indian Childhood Cirrhosis

[…] of hepatocellular failure and fibrosis. [slideshare.net]

Manifesting first as transient neonatal jaundice, the disease evolves into periportal fibrosis and cirrhosis during a period ranging from childhood to adolescence. [orpha.net]

These include elevated gamma-glutamyltransferase and alkaline phosphatase levels and, typically, marked fibrosis around portal bile ducts. [humpath.com]

Morton Neuroma

There is fibrosis and thickening of the blood vessel wall. [histopathology-india.net]

Edema and fibrosis occurs within the nerve, specifically within the epineurium and perineurium. [mortonsneuroma.com]

Treat the fibrosis and unlock the key to the inflammation. [acuroots.com]

Fibrinous Bronchitis

Atelectasia persistente en paciente con fibrosis quística: ¿debemos tratarla siempre con antibioterapia? [archbronconeumol.org]

With the exception of cystic fibrosis, these diseases may all have an allergic pulmonary reaction as the underlying cause. [kjorl.org]

Thirty other cases of bronchial casts have been reported previously in children 9 years of age or younger, only 12 of which were not associated with cystic fibrosis. [journals.sagepub.com]

Interstitial Lung Disease

The scarring is called fibrosis. The scarring related to pulmonary fibrosis causes lung tissue to get thick and stiff, making it hard for the body to take in oxygen. [fibrosis.northwesternmedicine.org]

ILD includes lung diseases such as pulmonary fibrosis, non-infectious pneumonia and vasculitis (blood vessel inflammation). What causes ILD and pulmonary fibrosis? [henryford.com]

[…] scarring or thickening (fibrosis) of tissues between the lung's alveoli, or air sacs. [columbiasurgery.org]

Idiopathic Pulmonary Fibrosis

[…] by fibrosis. [symptoma.com]

Idiopathic Pulmonary Fibrosis (IPF) Overview Idiopathic pulmonary fibrosis (IPF) is a disease marked by progressive scarring of the lungs. [upmc.com]

Presence of dilated bronchioles distributed between fibrosis, called the honey comb structure, is also characteristic of idiopathic pulmonary fibrosis. [symptoma.com]

Acute Cor Pulmonale

Idiopathic Pulmonary Fibrosis Clinical Research Network Investigators. Acute exacerbations of idiopathic pulmonary fibrosis. [ncbi.nlm.nih.gov]

Publisher American Lung Association, New York, NY Publication country United States Document type Article Language English Author keyword 8-nitroguanine idiopathic pulmonary fibrosis [pascal-francis.inist.fr]

Gender gap in cystic fibrosis mortality. Am J Epidemiol 1997;145:794-803. Orenstein DM, Higgins LW. Update on the role of exercise in cystic fibrosis. [cps.ca]