Fibrosis Increased: Causes & Reasons

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Possible Causes for Fibrosis Increased

Mitochondrial Myopathy with Reversible Cytochrome C Oxidase Deficiency

Case Reports Reversible mitochondrial myopathy with cytochrome c oxidase deficiency M K Salo et al. Arch Dis Child. 1992 Aug. Free PMC article Abstract Two siblings, a boy and a girl born in a nonconsanguineous marriage, presented with a similar clinical course. Sucking and breathing difficulties appeared within a few[…] [pubmed.ncbi.nlm.nih.gov]

Myocardial Fibrosis

BACKGROUND: Syndecan-4 is a transmembrane glycoprotein associated with inflammation and fibrosis. [ncbi.nlm.nih.gov]

RESULTS: Myocardial fibrosis was not significantly increased in Chol or Meth. [vuir.vu.edu.au]

fibrosis increases ( 14, 15 ). [eje.bioscientifica.com]

Pulmonary Fibrosis

Moreover, increased protein turnover was also detected in fibrotic lung tissue of IPF patients. [sciencedaily.com]

Strikingly, ibrutinib did not inhibit but exacerbated bleomycin-induced pulmonary fibrosis by increased epithelial cell apoptosis, and inflammation in the lung. [ncbi.nlm.nih.gov]

Long-standing pulmonary fibrosis also increases your risk of developing lung cancer. Lung complications. [mayoclinic.org]

Liver Fibrosis

Combination of diabetes and non-alcoholic fatty liver disease may increase liver fibrosis risk New research has uncovered that fatty liver and diabetes influence fibrosis. [belmarrahealth.com]

In this cohort study, we investigated whether platelets' increase after entecavir (ETV) therapy was associated with the improvement of liver fibrosis. [ncbi.nlm.nih.gov]

LSM was significantly correlated with fibrosis stage ( r = 0.756, P < 0.01). LSM values increased gradually with an increased fibrosis stage. [ncbi.nlm.nih.gov]

Oral Submucous Fibrosis

Recently, increased fibrosis in oral submucous fibrosis (OSMF) is linked with betel quid-related chronic irritation and myofibroblast. [ncbi.nlm.nih.gov]

Oral submucous fibrosis (OSF) is a chronic, insidious disease that is associated with significant functional morbidity and an increased risk for malignancy Oral Submucous [peoplebeatingcancer.org]

A sharp increase in the incidence of oral submucous fibrosis was noted after pan parag came onto the market, and the incidence continues to increase. [emedicine.medscape.com]

Guttate Scleroderma

Lung transplantation for systemic sclerosis compared with idiopathic pulmonary fibrosis: increased early mortality but comparable survival at one year. [link.springer.com]

Recurrent Nevus

In addition, involvement of adnexal structures and lentiginous growth may occur.1 In the intermediate and late phases of melanoma regression, increased fibrosis, loss of melanocytic [ncbi.nlm.nih.gov]

However, in intermediate and late regressions, with increasing fibrosis, loss of melanoma cells, diminishing inflammatory response, and effacement of the retiform epidermis [nature.com]

Pleural Fibrosis

Factors that were found to be associated with the presence and type of pleural fibrosis included increased age (p less than 0.001), more years in the trade (p less than 0.0001 [ncbi.nlm.nih.gov]

By contrast, hepatocyte growth factor stimulates non-fibrotic healing, while inhibition increases fibrosis. [ncbi.nlm.nih.gov]

Vascular endothelial growth factor inhibition has been shown to decrease pleural fibrosis in vivo. [ncbi.nlm.nih.gov]

Airway-Centered Interstitial Fibrosis

Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med, 158 (1998), pp. 1804-1808 [10.] T. Matsuse, T. [archbronconeumol.org]

Lung transplantation in a patient with airway-centered fibrosis. Am J Surg Pathol, 28 (2004), pp. 1540-1542 [9.] R.W. Tobin, C.E. Pope, C.A. Pellegrini, M.J. Emond, J. [archbronconeumol.org]

Familial Hypertrophic Cardiomyopathy Type 9

Histologically, there is disarray of the muscle fibers due to alterations in the sarcomere protein, fibrosis and increase of the interstitial matrix; they are not all specific [scielo.br]

Pyonephrosis

Consequences of chronic obstruction are a functional defect of the mucosa of the ureter, diminished blood supply, and an increased interstitial fibrosis of the obstructed [karger.com]

and renal stones that are not visible on the sonogram. [39] Computed tomography scan with images through the kidneys showing dilation of the collecting system, increased [emedicine.medscape.com]

[…] obstruction, the function of the kidney, and the severity of hydronephrosis, as well as the presence of other abdominal pathologies, including metastatic cancer, retroperitoneal fibrosis [emedicine.medscape.com]

Cystic Fibrosis

The life expectancy of people afflicted by cystic fibrosis has increased significantly. [aoporphan.com]

OBJECTIVE: Cystic fibrosis-related diabetes (CFRD) is a common complication of cystic fibrosis (CF), increasing patient morbidity and mortality. [ncbi.nlm.nih.gov]

Cystic fibrosis increases the risk of diabetes. Around 30 percent of people with cystic fibrosis develop diabetes by age 30. Blocked bile duct. [mayoclinic.org]

GRACILE Syndrome

The liver iron content slightly decreases with age, concomitantly with increasing liver fibrosis and cirrhosis. Abnormal transaminases and coagulation are noted. [en.wikipedia.org]

Secondary Pulmonary Fibrosis

Long-standing pulmonary fibrosis also increases your risk of developing lung cancer. Lung complications. [mayoclinic.org]

The cause of pulmonary fibrosis is unknown, but RA can increase your risk for it because of the inflammation. [healthline.com]

Typically, patients are in their forties and fifties when diagnosed while the incidence of idiopathic pulmonary fibrosis increases dramatically after the age of fifty. [en.wikipedia.org]

Lung Scarring

“There is a preconceived notion that increased fibrosis is pathological by definition. [brighamhealthvitallines.org]

Typically, patients are in their forties and fifties when diagnosed while the incidence of idiopathic pulmonary fibrosis increases dramatically after the age of fifty. [en.wikipedia.org]

fibrosis. [thoracic.org]

Nicergoline Poisoning

This conclusion is based on the review of data indicating increased risk of fibrosis (formation of excessive connective tissue that may damage organs and organism structure [halmed.hr]

Seckel-Like Syndrome Type Majoor-Krakauer

Young adults have an increased risk of hematological malignancies, including lymphoma and leukemia.[25][26] Other cancers, such as breast, liver, and esophageal cancer, are [statpearls.com]

[…] secondary to the reduction of immunoglobulins and the reduction of newly produced B and T cells.[24] These infections can further progress into bronchiectasis and pulmonary fibrosis [statpearls.com]

Idiopathic Pulmonary Fibrosis

BACKGROUND: Fibrocytes are implicated in Idiopathic Pulmonary Fibrosis (IPF) pathogenesis and increased proportions in the circulation are associated with poor prognosis. [ncbi.nlm.nih.gov]

Mortality from pulmonary fibrosis increased in the United States from 1992 to 2003. [nejmqianyan.cn]

Long-standing pulmonary fibrosis also increases your risk of developing lung cancer. Lung complications. [mayoclinic.org]

Acute Panmyelosis with Myelofibrosis

Reticulin staining confirmed extensive, severely increased fibrosis. Paraffin immunostaining revealed no increase in CD34+ blasts. [mplnet.com]

In addition, when there is leukoerythroblastosis in the peripheral blood along with increased fibrosis and increased atypical megakaryocytes and megakaryoblasts, then the [medical-dictionary.thefreedictionary.com]

[…] blasts and accompanying fibrosis of the BM 1 Bearman RM, Pangalis GA, Rappaport H (1979) Acute ("malignant") myelosclerosis. [codes.iarc.fr]

Unclassified Chronic Myeloproliferative Disease

[…] megakaryocytes which cluster, reticulin fibrosis, later trichrome fibrosis, and increased myeloid and erythroid precursors Fibrotic phase - collagenous fibrosis with lack [en.wikipedia.org]

Development of bone marrow fibrosis : As myeloproliferative neoplasia progress bone marrow fibrosis increases. [allaboutblood.com]

Biopsy shows a highly cellular bone marrow, with an increased amount of dysplastic megakaryocytes, fibrosis, and relative hypoplasia of the erythroid and granulocytic lineage [iupui.edu]

Congenital Hepatic Fibrosis

Increased hepatic copper concentration in this case may have contributed to the production of liver damage. [ncbi.nlm.nih.gov]

Histologically the liver is characterized by portal fibrosis and an increase in portal ductal structures. [ncbi.nlm.nih.gov]

It is a progressive process, and with the passage of time hepatic fibrosis increases and PH worsens. [jpma.org.pk]

Renal Fibrosis

[…] by increased deposition of collagen in the kidney. [portlandpress.com]

Their experiments showed that in the presence of TASCC, the secretion of fibrosis-promoting factors increased. [hsci.harvard.edu]

Figure 1: Magnetic resonance elastography-derived stiffness scores increase with increasing Banff fibrosis score. [ukidney.com]

Macronodular Cirrhosis

At year 7, probabilities for HCC development jumped to 16% in patients with F4 fibrosis and increased to 2% in patients with F3 fibrosis. [ncbi.nlm.nih.gov]

uncommon but increasing with increased survival medications (e.g. methotrexate) The diagnosis is made either at screening for cirrhosis due to known risk factors, elevated [radiopaedia.org]

[…] had a 3-fold increase in liver disease related complications and a 2-fold increase in overall mortality compared to those with F3 fibrosis.[ 14 ] The average time for patients [ncbi.nlm.nih.gov]

Primary Myelofibrosis

[…] mildly increased cellularity or is hypocellular, with moderate to marked reticulin fibrosis. [patient-help.com]

Myelofibrosis is one of the myeloproliferative neoplasms (clonal stem cell disorders) in which increased marrow fibrosis is the dominant feature. [rcpa.edu.au]

increase in microvessel density, and osteosclerosis. [doi.org]

Chronic Thyroiditis

increased IgG4-positive plasma cell in the thyroid and high IgG4 level in the serum. [ncbi.nlm.nih.gov]

The fibrosis does not extend beyond the thyroid capsule. [hormones.gr]

There was no correlation between IgG4 levels and the amount of fibrosis in patients with or without HT. [ohsu.pure.elsevier.com]

Non-Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) represents a spectrum, including 'simple' steatosis, non-alcoholic steatohepatitis (NASH), and fibrosis. [ncbi.nlm.nih.gov]

Introduction : Non-alcoholic fatty liver disease (NAFLD) represents a spectrum, including ‘simple’ steatosis, non-alcoholic steatohepatitis (NASH), and fibrosis. [doi.org]

Risks of NASH and advanced fibrosis increased significantly with plasma concentration of TSH (Ptrend CONCLUSIONS: Subclinical hypothyroidism and low-normal thyroid function [ncbi.nlm.nih.gov]

Absent Thumb - Short Stature - Immunodeficiency Syndrome

Increased alpha-fetoprotein Increased radiosensitivity Genetics[edit] This condition is due to mutations in the RNF168 gene. [en.wikipedia.org]

Progressive spastic quadriplegia Metaphyseal sclerosis Madelung deformity Decrease in T cell count Spondylometaphyseal dysplasia Immune dysregulation Tubulointerstitial fibrosis [mendelian.co]

The likelihood of a baby being born with Down syndrome increases with the mother's age. [encyclopedia.com]

Nephrogenic Systemic Fibrosis

MAIN OUTCOME MEASURE: Reduction of skin fibrosis and increase in joint mobility evaluated by the modified Rodnan skin score and a goniometer. [ncbi.nlm.nih.gov]

It is unknown whether increased Gd excretion will lead to long-term clinical improvements in late stages of nephrogenic systemic fibrosis. [ncbi.nlm.nih.gov]

In immunofluorescence staining, the expression of ETR-A in fibroblasts in dermal fibrosis lesion of NSF was increased. [ncbi.nlm.nih.gov]

Meckel Syndrome Type 8

[…] of collagenous connective tissue i.e.portal fibrosis (Figure 6). [npplweb.com]

MedGen UID: 477530 •Concept ID: C3275899 • Finding An increase in amplitude of waves returned in ultrasonography of the kidney, which is generally displayed as increased [ncbi.nlm.nih.gov]

Sections from liver showed features of ductal plate malformation:proliferation and dilatation of the bile ducts arranged in a ring like manner in few portal tracts with increase [npplweb.com]

Congenital Absence of the Vas Deferens

The risk of cystic fibrosis (CF) is increased, genetic diagnosis and counseling can assess the risk individually. [urology-textbook.com]

Men with CBAVD who choose to father children through assisted reproduction have an increased risk of having a child with cystic fibrosis. [rarediseases.info.nih.gov]

Men with this condition who choose to father children through assisted reproduction have an increased risk of having a child with cystic fibrosis. [ghr.nlm.nih.gov]